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> Protein (NX_Q8WX92)
Protein (NX_Q8WX92)
Protein
Gene SymbolNELFB to neXtProt (NX_Q8WX92)
DescriptionNegative elongation factor B
Chromosome9
Location9q34.3 (140149625 ~ 140167998) to Ensembl
Sequene Features : Isoforms 1, Variants 10, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of viral transcription
.negative regulation of transcription, DNA-templated
.viral process
  + 3 more...
.N/A .NELF complex
.cytoplasm
.nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 10 5
2014-09-19protein level
1 36 5
2014-05-27protein level
1 36 5
2014-02-25protein level
1 35 5
2013-12-09protein level
1 26 5
2013-11-01protein level
1 26 3
2013-09-12protein level
1 26 3
2013-08-17protein level
1 26 3
2013-07-15protein level
1 18 3
2013-06-11protein level
1 18 3
2013-02-12protein level
1 6 3
2012-12-20protein level
1 6 3
2012-10-30protein level
1 7 3
2012-10-07protein level
1 7 3
2012-08-24protein level
1 7 3
2012-07-28protein level
1 7 3
2012-06-08protein level
1 9 3
2012-05-07protein level
1 4 3
2012-04-10protein level
1 4 3
2012-01-13protein level
1 6 3
2011-12-20protein level
1 6 3
2011-11-11protein level
1 6 2
2011-08-23protein level
1 6 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8WX92-1
26 0 0 65655.2234
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-347721,EBI-716083 DENR  
  .ribosome disassembly
.IRES-dependent translational initiation
.formation of translation preinitiation complex
.translation initiation factor activity .N/A
2 EBI-347721,EBI-722504 KHDRBS3  
  .spermatogenesis
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.poly(A) RNA binding
.RNA binding
.nucleoplasm
.nucleus
3 EBI-347721,EBI-515315 FYN  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of protein localization to nucleus
.cellular response to peptide hormone stimulus
  + 47 more...
.growth factor receptor binding
.ephrin receptor binding
.metal ion binding
  + 4 more...
.extrinsic component of cytoplasmic side of plasma membrane
.postsynaptic density
.plasma membrane
  + 5 more...
4 EBI-347721,EBI-2691601 MGST1  
  .glutathione derivative biosynthetic process
.cellular response to lipid hydroperoxide
.protein homotrimerization
  + 8 more...
.glutathione binding
.glutathione peroxidase activity
.glutathione transferase activity
.apical part of cell
.integral component of membrane
.endoplasmic reticulum membrane
  + 6 more...
5 EBI-347721,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
6 EBI-347721,EBI-348444 NELFE  
  .negative regulation of mRNA polyadenylation
.positive regulation of viral transcription
.negative regulation of transcription elongation from RNA polymerase II promoter
  + 4 more...
.poly(A) RNA binding
.RNA binding
.nucleotide binding
.NELF complex
.mitochondrion
.nucleoplasm
.nucleus
7 EBI-347721,EBI-79464 PIK3R1  
  .positive regulation of endoplasmic reticulum unfolded protein response
.positive regulation of establishment of protein localization to plasma membrane
.growth hormone receptor signaling pathway
  + 41 more...
.1-phosphatidylinositol-3-kinase regulator activity
.insulin receptor substrate binding
.insulin binding
  + 9 more...
.membrane
.phosphatidylinositol 3-kinase complex, class IA
.phosphatidylinositol 3-kinase complex
  + 5 more...
8 EBI-347721,EBI-349905 BRCA1  
  .positive regulation of histone H4-K16 acetylation
.positive regulation of histone H3-K9 acetylation
.negative regulation of reactive oxygen species metabolic process
  + 51 more...
.androgen receptor binding
.transcription regulatory region DNA binding
.ubiquitin protein ligase binding
  + 9 more...
.BRCA1-A complex
.protein complex
.BRCA1-BARD1 complex
  + 9 more...
9 EBI-347721,EBI-354932 HSPA9  
  .cellular protein metabolic process
.negative regulation of apoptotic process
.protein targeting to mitochondrion
  + 2 more...
.unfolded protein binding
.poly(A) RNA binding
.ubiquitin protein ligase binding
.ATP binding
.extracellular exosome
.mitochondrial nucleoid
.focal adhesion
  + 3 more...
10 EBI-347721,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites251
bladder33
blood122
bone69
brain75
cervix164
connective tissue6
embryonic tissue79
eye76
intestine81
kidney42
liver34
lung56
lymph67
lymph node55
mammary gland46
muscle56
nerve128
ovary98
pancreas56
placenta81
prostate105
salivary gland49
skin90
spleen18
stomach62
testis50
thyroid21
uterus99
vascular77
Health State
TissuesTPM*
normal49
breast (mammary gland) tumor64
cervical tumor115
chondrosarcoma60
colorectal tumor106
gastrointestinal tumor135
germ cell tumor117
glioma195
head and neck tumor7
kidney tumor116
leukemia84
liver tumor52
lung tumor136
lymphoma96
non-neoplasia41
ovarian tumor52
pancreatic tumor76
primitive neuroectodermal tumor of the CNS165
prostate cancer163
retinoblastoma129
skin tumor135
soft tissue/muscle tissue tumor159
uterine tumor44
Developmental Stage
TissuesTPM*
adult70
embryoid body14
blastocyst130
fetus28
infant85
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue18.3
adrenal gland13.3
appendix16.6
bone marrow12.5
cerebral cortex18.5
colon18.9
duodenum16.5
esophagus16.8
gallbladder14.2
heart muscle17
kidney19.5
liver6.8
lung19.6
lymph node20.9
ovary20
pancreas12.3
placenta16.7
prostate18
salivary gland18.7
skin19.9
small intestine18.8
spleen22.2
stomach19.6
testis21.7
thyroid gland15.4
urinary bladder17.4
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowMedium
breastHigh
bronchusHigh
cerebellumMedium
cerebral cortexMedium
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2High
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleLow
hippocampusLow
kidneyMedium
lateral ventricleMedium
liverLow
lungMedium
lymph nodeMedium
nasopharynxHigh
oral mucosaHigh
ovaryMedium
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateMedium
rectumHigh
salivary glandHigh
seminal vesicleMedium
skeletal muscleLow
skin 1High
skin 2High
small intestineHigh
soft tissue 1Low
soft tissue 2Low
spleenLow
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*611180, gene) Cofactor of brca1; COBRA1OMIM


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