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> Protein (NX_Q8WXB1)
Protein (NX_Q8WXB1)
Protein
Gene SymbolMETTL21A to neXtProt (NX_Q8WXB1)
DescriptionProtein N-lysine methyltransferase METTL21A
Chromosome2
Location2q33.3 (208445355 ~ 208490652) to Ensembl
Sequene Features : Isoforms 2, Variants 31, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.peptidyl-lysine methylation
.protein methylation
.ATPase binding
.Hsp70 protein binding
.protein-lysine N-methyltransferase activity
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 31 0
2014-09-19protein level
2 25 0
2014-05-27protein level
2 25 0
2014-02-25protein level
2 25 0
2013-12-09protein level
2 20 0
2013-11-01protein level
2 20 0
2013-09-12protein level
2 20 0
2013-08-17protein level
2 20 0
2013-07-15protein level
2 11 0
2013-06-11protein level
2 11 0
2013-02-12protein level
2 7 0
2012-12-20protein level
2 6 0
2012-10-30protein level
2 7 0
2012-10-07protein level
2 7 0
2012-08-24transcript level
2 5 0
2012-07-28transcript level
2 5 0
2012-06-08transcript level
2 6 0
2012-05-07transcript level
2 6 0
2012-04-10transcript level
2 6 0
2012-01-13transcript level
2 5 0
2011-12-20transcript level
2 5 0
2011-11-11transcript level
2 5 0
2011-08-23transcript level
2 5 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8WXB1-1
5 3 0 24584.7629
NX_Q8WXB1-2
1 3 0 9603.052
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-8652459,EBI-739832 LNX1  
  .protein homooligomerization
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasm
2 EBI-8652459,EBI-747353 ATRIP  
  .DNA repair
.DNA replication
.DNA damage checkpoint
.K63-linked polyubiquitin binding .nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites50
bladder33
blood32
bone marrow20
brain11
connective tissue6
embryonic tissue18
eye4
heart11
kidney18
lung8
lymph90
mouth15
ovary19
pancreas37
placenta7
prostate15
skin23
stomach20
testis4
thymus25
uterus17
vascular19
Health State
TissuesTPM*
normal10
gastrointestinal tumor33
germ cell tumor22
glioma27
head and neck tumor7
leukemia52
lung tumor9
lymphoma55
ovarian tumor13
pancreatic tumor19
primitive neuroectodermal tumor of the CNS15
prostate cancer28
skin tumor31
soft tissue/muscle tissue tumor31
Developmental Stage
TissuesTPM*
adult9
embryoid body42
fetus14
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue7.7
adrenal gland8.5
appendix13.4
bone marrow15
cerebral cortex11.8
colon11.6
duodenum8.5
esophagus6.5
gallbladder8.6
heart muscle10.2
kidney10.4
liver7.6
lung9.3
lymph node19.9
ovary9.8
pancreas3.8
placenta12.3
prostate10
salivary gland7.5
skin3.4
small intestine8.3
spleen17.1
stomach12.5
testis6.8
thyroid gland14.8
urinary bladder13.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1acute lymphocytic leukemiaCGP


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