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	> Protein (NX_Q8WXE1) Protein (NX_Q8WXE1) Protein Gene Symbol ATRIP to neXtProt (NX_Q8WXE1) Description ATR-interacting protein Chromosome 3 Location 3p21.31 (48488114 ~ 48507115) to Ensembl Sequene Features : Isoforms 4, Variants 58, PTMs 7 to neXtProt Sequence Features Gene Ontologies GO: Biological Process GO: Mulecular Function GO: Cellular Component .DNA repair .DNA replication .DNA damage checkpoint .K63-linked polyubiquitin binding .nucleoplasm .nucleus Proteomic Evidences Release Protein Evidence Pr Ab Isoforms Variants PTMs 2015-01-01 protein level 4 58 7 2014-09-19 protein level 4 45 7 2014-05-27 protein level 4 45 7 2014-02-25 protein level 4 45 7 2013-12-09 protein level 4 38 7 2013-11-01 protein level 4 36 7 2013-09-12 protein level 4 36 6 2013-08-17 protein level 4 36 6 2013-07-15 protein level 3 28 6 2013-06-11 protein level 3 28 6 2013-02-12 protein level 3 16 15 2012-12-20 protein level 3 15 15 2012-10-30 protein level 3 17 15 2012-10-07 protein level 3 17 5 2012-08-24 protein level 3 17 5 2012-07-28 protein level 3 17 5 2012-06-08 protein level 3 26 5 2012-05-07 protein level 3 23 5 2012-04-10 protein level 3 23 5 2012-01-13 protein level 3 19 5 2011-12-20 protein level 3 19 5 2011-11-11 protein level 3 19 4 2011-08-23 protein level 3 19 4 Protein Isoforms Isoform Ac   U G S Mw (Da) NX_Q8WXE1-1 0 32 0 85783.2207 NX_Q8WXE1-2 1 30 0 82950.7621 NX_Q8WXE1-3 0 29 0 76287.6415 NX_Q8WXE1-5 0 28 0 72315.5751 : Uniquely mapped peptide : Gene-specific peptide : Shared peptide Interacting Partners No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component 1 EBI-747353,EBI-1055079 POLR1C     .negative regulation of gene expression, epigenetic .innate immune response .regulation of gene expression, epigenetic   + 9 more... .DNA-directed RNA polymerase activity .DNA binding .cytosol .DNA-directed RNA polymerase I complex .DNA-directed RNA polymerase III complex .nucleoplasm 2 EBI-747353,EBI-742487 SPRY2     .positive regulation of protein serine/threonine kinase activity .positive regulation of ERK1 and ERK2 cascade .negative regulation of ERK1 and ERK2 cascade   + 19 more... .protein serine/threonine kinase activator activity .protein serine/threonine kinase inhibitor activity .protein kinase binding .ruffle membrane .microtubule cytoskeleton .plasma membrane   + 2 more... 3 EBI-747353,EBI-1757866 MOS     .negative regulation of metaphase/anaphase transition of meiotic cell cycle .establishment of meiotic spindle orientation .protein autophosphorylation   + 6 more... .ATP binding .MAP kinase kinase kinase activity .protein serine/threonine kinase activity .cytoplasm 4 EBI-747353,EBI-947132 SCG2     .negative regulation of extrinsic apoptotic signaling pathway .negative regulation of endothelial cell apoptotic process .induction of positive chemotaxis   + 10 more... .chemoattractant activity .cytokine activity .secretory granule .extracellular space 5 EBI-747353,EBI-10200618 MX2     .type I interferon signaling pathway .regulation of cell cycle .defense response to virus   + 8 more... .GTP binding .GTPase activity .cytosol .cytoplasm .nuclear pore .nucleus 6 EBI-747353,EBI-1383449 CDK9     .positive regulation of histone H2B ubiquitination .positive regulation of mRNA 3'-UTR binding .negative regulation of mRNA polyadenylation   + 18 more... .transcription regulatory region DNA binding .snRNA binding .RNA polymerase II carboxy-terminal domain kinase activity   + 5 more... .intracellular membrane-bounded organelle .PML body .membrane   + 4 more... 7 EBI-747353,EBI-10172380 FAM208B     .N/A .N/A .cytoplasm .nucleoplasm .nucleus 8 EBI-747353,EBI-946029 C1orf94     .N/A .N/A .N/A 9 EBI-747353,EBI-749727 FAM156B     .N/A .N/A .integral component of membrane .nuclear envelope 10 EBI-747353,EBI-739832 LNX1     .protein homooligomerization .protein ubiquitination involved in ubiquitin-dependent protein catabolic process .ligase activity .zinc ion binding .ubiquitin-protein transferase activity .cytoplasm 11 EBI-747353,EBI-8652459 METTL21A     .peptidyl-lysine methylation .protein methylation .ATPase binding .Hsp70 protein binding .protein-lysine N-methyltransferase activity .cytoplasm 12 EBI-747353,EBI-10299032 CCDC28B     .cilium assembly .N/A .centrosome .cytoplasm 13 EBI-747353,EBI-739784 CINP     .cell division .cell cycle .DNA repair .DNA replication .N/A .nucleus 14 EBI-747353,EBI-10172526 MID2     .negative regulation of viral release from host cell .positive regulation of NF-kappaB transcription factor activity .positive regulation of sequence-specific DNA binding transcription factor activity   + 6 more... .phosphoprotein binding .protein heterodimerization activity .protein homodimerization activity   + 3 more... .extracellular exosome .microtubule .cytoplasm 15 EBI-747353,EBI-396137 CDC23     .protein K11-linked ubiquitination .regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle .positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition   + 11 more... .ubiquitin-protein transferase activity .cytosol .anaphase-promoting complex .nucleoplasm .intracellular EST expression level of Protein Coding Gene (ref. NCBI UniGene EST) Body Sites Tissues TPM* ascites 25 bladder 33 blood 49 bone marrow 41 brain 14 connective tissue 20 embryonic tissue 14 esophagus 49 eye 9 intestine 17 liver 19 lymph 22 mammary gland 26 muscle 9 ovary 19 pancreas 9 placenta 24 prostate 15 testis 50 thymus 37 uterus 34 vascular 19 Health State Tissues TPM* normal 15 breast (mammary gland) tumor 21 chondrosarcoma 12 esophageal tumor 57 gastrointestinal tumor 16 germ cell tumor 15 leukemia 42 liver tumor 31 lymphoma 13 non-neoplasia 10 pancreatic tumor 19 primitive neuroectodermal tumor of the CNS 47 retinoblastoma 21 soft tissue/muscle tissue tumor 23 uterine tumor 55 Developmental Stage Tissues TPM* adult 11 embryoid body 14 blastocyst 32 fetus 21 infant 42 TPM*: Transcripts per million; transcript expression level measured by expression sequence tags. Expression level of Protein (ref. Human Protein Atlas) RNA-Seq. Tissues FPKM adipose tissue 4.2 adrenal gland 3.9 appendix 5.5 bone marrow 3.7 cerebral cortex 2.9 colon 3.8 duodenum 2.5 esophagus 5 gallbladder 3.5 heart muscle 2.7 kidney 3.5 liver 1.9 lung 4.7 lymph node 6.1 ovary 5.3 pancreas 2.3 placenta 5.7 prostate 4.3 salivary gland 2.5 skin 5.2 small intestine 3 spleen 4.3 stomach 3.7 testis 21.9 thyroid gland 8.6 urinary bladder 5.1 Tissues Tissues Expression level adrenal gland Medium appendix High bone marrow Low breast Medium bronchus Medium cerebellum High cerebral cortex High cervix, uterine High colon Medium duodenum Low endometrium 1 Medium endometrium 2 High epididymis Medium esophagus Medium fallopian tube High gallbladder High heart muscle High hippocampus High kidney Medium lateral ventricle High liver High lung High lymph node Low nasopharynx High oral mucosa Low ovary Medium pancreas High parathyroid gland Low placenta High prostate High rectum Medium salivary gland High seminal vesicle Medium skeletal muscle High skin 1 High skin 2 Medium small intestine Low smooth muscle Medium soft tissue 1 Low soft tissue 2 Medium spleen Low stomach 1 Medium stomach 2 Medium testis Medium thyroid gland High tonsil Medium urinary bladder Medium vagina Medium Cancer Tumor Number of patients and Staining levels breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testis cancer thyroid cancer urothelial cancer RNA-seq colour codes Highly expressed RNAs (FPKM >50) Moderately expressed RNAs (50> FPKM >10) Lower expressed RNAs (10> FPKM >1) The lowest expressed RNAs (FPKM value of 0 or 1) Expression level colour codes Highly expressed protein Moderately expressed protein Lower expressed protein Staining level colour codes Highly expressed protein Moderately expressed protein Lower expressed protein Not Detected Disease No. Disease Description Ref. 1 (*606605, gene) Atr-interacting protein; ATRIP OMIM

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