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> Protein (NX_Q8WXE1)
Protein (NX_Q8WXE1)
Protein
Gene SymbolATRIP to neXtProt (NX_Q8WXE1)
DescriptionATR-interacting protein
Chromosome3
Location3p21.31 (48488114 ~ 48507115) to Ensembl
Sequene Features : Isoforms 4, Variants 58, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.DNA repair
.DNA replication
.DNA damage checkpoint
.K63-linked polyubiquitin binding .nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 58 7
2014-09-19protein level
4 45 7
2014-05-27protein level
4 45 7
2014-02-25protein level
4 45 7
2013-12-09protein level
4 38 7
2013-11-01protein level
4 36 7
2013-09-12protein level
4 36 6
2013-08-17protein level
4 36 6
2013-07-15protein level
3 28 6
2013-06-11protein level
3 28 6
2013-02-12protein level
3 16 15
2012-12-20protein level
3 15 15
2012-10-30protein level
3 17 15
2012-10-07protein level
3 17 5
2012-08-24protein level
3 17 5
2012-07-28protein level
3 17 5
2012-06-08protein level
3 26 5
2012-05-07protein level
3 23 5
2012-04-10protein level
3 23 5
2012-01-13protein level
3 19 5
2011-12-20protein level
3 19 5
2011-11-11protein level
3 19 4
2011-08-23protein level
3 19 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8WXE1-1
0 32 0 85783.2207
NX_Q8WXE1-2
1 30 0 82950.7621
NX_Q8WXE1-3
0 29 0 76287.6415
NX_Q8WXE1-5
0 28 0 72315.5751
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-747353,EBI-1055079 POLR1C  
  .negative regulation of gene expression, epigenetic
.innate immune response
.regulation of gene expression, epigenetic
  + 9 more...
.DNA-directed RNA polymerase activity
.DNA binding
.cytosol
.DNA-directed RNA polymerase I complex
.DNA-directed RNA polymerase III complex
.nucleoplasm
2 EBI-747353,EBI-742487 SPRY2  
  .positive regulation of protein serine/threonine kinase activity
.positive regulation of ERK1 and ERK2 cascade
.negative regulation of ERK1 and ERK2 cascade
  + 19 more...
.protein serine/threonine kinase activator activity
.protein serine/threonine kinase inhibitor activity
.protein kinase binding
.ruffle membrane
.microtubule cytoskeleton
.plasma membrane
  + 2 more...
3 EBI-747353,EBI-1757866 MOS  
  .negative regulation of metaphase/anaphase transition of meiotic cell cycle
.establishment of meiotic spindle orientation
.protein autophosphorylation
  + 6 more...
.ATP binding
.MAP kinase kinase kinase activity
.protein serine/threonine kinase activity
.cytoplasm
4 EBI-747353,EBI-947132 SCG2  
  .negative regulation of extrinsic apoptotic signaling pathway
.negative regulation of endothelial cell apoptotic process
.induction of positive chemotaxis
  + 10 more...
.chemoattractant activity
.cytokine activity
.secretory granule
.extracellular space
5 EBI-747353,EBI-10200618 MX2  
  .type I interferon signaling pathway
.regulation of cell cycle
.defense response to virus
  + 8 more...
.GTP binding
.GTPase activity
.cytosol
.cytoplasm
.nuclear pore
.nucleus
6 EBI-747353,EBI-1383449 CDK9  
  .positive regulation of histone H2B ubiquitination
.positive regulation of mRNA 3'-UTR binding
.negative regulation of mRNA polyadenylation
  + 18 more...
.transcription regulatory region DNA binding
.snRNA binding
.RNA polymerase II carboxy-terminal domain kinase activity
  + 5 more...
.intracellular membrane-bounded organelle
.PML body
.membrane
  + 4 more...
7 EBI-747353,EBI-10172380 FAM208B  
  .N/A .N/A .cytoplasm
.nucleoplasm
.nucleus
8 EBI-747353,EBI-946029 C1orf94  
  .N/A .N/A .N/A
9 EBI-747353,EBI-749727 FAM156B  
  .N/A .N/A .integral component of membrane
.nuclear envelope
10 EBI-747353,EBI-739832 LNX1  
  .protein homooligomerization
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasm
11 EBI-747353,EBI-8652459 METTL21A  
  .peptidyl-lysine methylation
.protein methylation
.ATPase binding
.Hsp70 protein binding
.protein-lysine N-methyltransferase activity
.cytoplasm
12 EBI-747353,EBI-10299032 CCDC28B  
  .cilium assembly .N/A .centrosome
.cytoplasm
13 EBI-747353,EBI-739784 CINP  
  .cell division
.cell cycle
.DNA repair
.DNA replication
.N/A .nucleus
14 EBI-747353,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.microtubule
.cytoplasm
15 EBI-747353,EBI-396137 CDC23  
  .protein K11-linked ubiquitination
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
  + 11 more...
.ubiquitin-protein transferase activity .cytosol
.anaphase-promoting complex
.nucleoplasm
.intracellular
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
bladder33
blood49
bone marrow41
brain14
connective tissue20
embryonic tissue14
esophagus49
eye9
intestine17
liver19
lymph22
mammary gland26
muscle9
ovary19
pancreas9
placenta24
prostate15
testis50
thymus37
uterus34
vascular19
Health State
TissuesTPM*
normal15
breast (mammary gland) tumor21
chondrosarcoma12
esophageal tumor57
gastrointestinal tumor16
germ cell tumor15
leukemia42
liver tumor31
lymphoma13
non-neoplasia10
pancreatic tumor19
primitive neuroectodermal tumor of the CNS47
retinoblastoma21
soft tissue/muscle tissue tumor23
uterine tumor55
Developmental Stage
TissuesTPM*
adult11
embryoid body14
blastocyst32
fetus21
infant42
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue4.2
adrenal gland3.9
appendix5.5
bone marrow3.7
cerebral cortex2.9
colon3.8
duodenum2.5
esophagus5
gallbladder3.5
heart muscle2.7
kidney3.5
liver1.9
lung4.7
lymph node6.1
ovary5.3
pancreas2.3
placenta5.7
prostate4.3
salivary gland2.5
skin5.2
small intestine3
spleen4.3
stomach3.7
testis21.9
thyroid gland8.6
urinary bladder5.1
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowLow
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonMedium
duodenumLow
endometrium 1Medium
endometrium 2High
epididymisMedium
esophagusMedium
fallopian tubeHigh
gallbladderHigh
heart muscleHigh
hippocampusHigh
kidneyMedium
lateral ventricleHigh
liverHigh
lungHigh
lymph nodeLow
nasopharynxHigh
oral mucosaLow
ovaryMedium
pancreasHigh
parathyroid glandLow
placentaHigh
prostateHigh
rectumMedium
salivary glandHigh
seminal vesicleMedium
skeletal muscleHigh
skin 1High
skin 2Medium
small intestineLow
smooth muscleMedium
soft tissue 1Low
soft tissue 2Medium
spleenLow
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandHigh
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606605, gene) Atr-interacting protein; ATRIPOMIM


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