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> Protein (NX_Q8WXF1)
Protein (NX_Q8WXF1)
Protein
Gene SymbolPSPC1 to neXtProt (NX_Q8WXF1)
DescriptionParaspeckle component 1
Chromosome13
Location13q12.11 (20248896 ~ 20357142) to Ensembl
Sequene Features : Isoforms 2, Variants 67, PTMs 10 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.rhythmic process
.negative regulation of transcription, DNA-templated
.regulation of circadian rhythm
.transcription, DNA-templated
.poly(A) RNA binding
.core promoter binding
.nucleotide binding
.paraspeckles
.nuclear speck
.nuclear matrix
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 67 10
2014-09-19protein level
2 52 10
2014-05-27protein level
2 52 10
2014-02-25protein level
2 52 10
2013-12-09protein level
2 44 10
2013-11-01protein level
2 42 8
2013-09-12protein level
2 42 8
2013-08-17protein level
2 42 8
2013-07-15protein level
2 25 7
2013-06-11protein level
2 25 7
2013-02-12protein level
2 6 10
2012-12-20protein level
2 6 10
2012-10-30protein level
2 10 10
2012-10-07protein level
2 10 7
2012-08-24protein level
2 5 7
2012-07-28protein level
2 5 7
2012-06-08protein level
2 11 7
2012-05-07protein level
2 9 7
2012-04-10protein level
2 9 7
2012-01-13protein level
2 14 7
2011-12-20protein level
2 14 7
2011-11-11protein level
2 14 5
2011-08-23protein level
2 14 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8WXF1-1
6 13 0 58706.0259
NX_Q8WXF1-2
1 13 0 45542.1537
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1392258,EBI-350527 NONO  
  .negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
.negative regulation of transcription, DNA-templated
.regulation of circadian rhythm
  + 6 more...
.poly(A) RNA binding
.identical protein binding
.core promoter binding
.nucleotide binding
.paraspeckles
.nuclear speck
.nuclear matrix
  + 4 more...
2 EBI-1392258,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites75
bladder100
blood57
bone41
bone marrow41
brain75
cervix61
connective tissue46
embryonic tissue65
eye43
heart55
intestine107
kidney104
liver29
lung104
lymph564
lymph node245
mammary gland112
nerve193
ovary39
pancreas46
parathyroid97
placenta109
prostate31
skin37
spleen56
stomach83
testis78
thymus163
thyroid128
trachea38
uterus99
vascular116
Health State
TissuesTPM*
normal79
bladder carcinoma113
breast (mammary gland) tumor75
cervical tumor86
chondrosarcoma84
colorectal tumor88
gastrointestinal tumor67
germ cell tumor148
glioma46
head and neck tumor44
kidney tumor58
leukemia63
liver tumor52
lung tumor116
lymphoma387
non-neoplasia41
ovarian tumor39
pancreatic tumor47
primitive neuroectodermal tumor of the CNS133
prostate cancer9
skin tumor31
soft tissue/muscle tissue tumor15
uterine tumor88
Developmental Stage
TissuesTPM*
adult75
embryoid body28
blastocyst113
neonate128
fetus87
infant340
juvenile143
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue15.8
adrenal gland20.4
appendix24.5
bone marrow39.6
cerebral cortex22.7
colon20.5
duodenum16.7
esophagus16.6
gallbladder20.9
heart muscle14.4
kidney17
liver8.7
lung18.7
lymph node34.1
ovary21.4
pancreas6.3
placenta22.8
prostate18.9
salivary gland9.8
skin16.5
small intestine16.7
spleen22.8
stomach17.7
testis38.5
thyroid gland21.4
urinary bladder25.1
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowMedium
breastHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisMedium
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleLow
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverMedium
lungHigh
lymph nodeMedium
nasopharynxHigh
oral mucosaMedium
ovaryLow
pancreasMedium
parathyroid glandMedium
placentaHigh
prostateMedium
rectumHigh
salivary glandHigh
seminal vesicleMedium
skeletal muscleHigh
skin 1High
skin 2Medium
small intestineHigh
smooth muscleMedium
soft tissue 1Medium
soft tissue 2High
spleenMedium
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*612408, gene) Paraspeckle component 1; PSPC1OMIM


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