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> Protein (NX_Q8WXH0)
Protein (NX_Q8WXH0)
Protein
Gene SymbolSYNE2 to neXtProt (NX_Q8WXH0)
DescriptionNesprin-2
Chromosome14
Location14q23.2 (64319683 ~ 64693165) to Ensembl
Sequene Features : Isoforms 9, Variants 853, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cytoskeletal anchoring at nuclear membrane
.centrosome localization
.protein localization to nucleus
  + 6 more...
.actin binding .extracellular exosome
.intermediate filament cytoskeleton
.LINC complex
  + 16 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
9 853 9
2014-09-19protein level
9 690 9
2014-05-27protein level
9 690 9
2014-02-25protein level
9 687 9
2013-12-09protein level
9 512 9
2013-11-01protein level
9 491 8
2013-09-12protein level
9 491 8
2013-08-17protein level
9 491 8
2013-07-15protein level
9 330 8
2013-06-11protein level
9 330 8
2013-02-12protein level
9 200 22
2012-12-20protein level
9 180 22
2012-10-30protein level
9 242 22
2012-10-07protein level
9 242 8
2012-08-24protein level
9 228 8
2012-07-28protein level
9 227 8
2012-06-08protein level
9 246 8
2012-05-07protein level
9 215 8
2012-04-10protein level
9 215 8
2012-01-13protein level
9 126 8
2011-12-20protein level
9 126 8
2011-11-11protein level
9 126 8
2011-08-23protein level
9 126 8
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8WXH0-1
0 346 3 795941.2542
NX_Q8WXH0-2
0 346 3 798359.4827
NX_Q8WXH0-3
0 33 3 97977.6219
NX_Q8WXH0-4
0 30 2 87348.5768
NX_Q8WXH0-5
0 23 0 62160.1685
NX_Q8WXH0-6
0 19 0 48128.8076
NX_Q8WXH0-7
2 153 3 376955.7449
NX_Q8WXH0-8
2 10 0 32218.4466
NX_Q8WXH0-9
1 10 0 30250.5286
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-6170976,EBI-2796904 SUN1  
  .nuclear matrix anchoring at nuclear membrane
.cytoskeletal anchoring at nuclear membrane
.nuclear envelope organization
.N/A .intracellular membrane-bounded organelle
.LINC complex
.nuclear membrane
  + 3 more...
2 EBI-2372294,EBI-1044964 SUN2  
  .nuclear matrix anchoring at nuclear membrane
.cytoskeletal anchoring at nuclear membrane
.centrosome localization
  + 5 more...
.identical protein binding
.microtubule binding
.lamin binding
.LINC complex
.nuclear membrane
.endosome membrane
  + 4 more...
3 EBI-2372294,EBI-741243 APPL1  
  .extrinsic apoptotic signaling pathway in absence of ligand
.extrinsic apoptotic signaling pathway
.regulation of establishment of protein localization to plasma membrane
  + 7 more...
.protein kinase B binding
.identical protein binding
.extracellular exosome
.early endosome membrane
.vesicle membrane
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites50
bladder234
blood89
bone41
brain71
cervix41
embryonic tissue61
esophagus198
eye90
heart290
intestine73
kidney137
larynx340
liver43
lung47
lymph67
lymph node200
mammary gland171
mouth317
muscle94
ovary49
pancreas42
pharynx98
pituitary gland60
placenta113
prostate105
skin23
spleen56
stomach104
testis85
thymus138
thyroid300
trachea154
uterus90
vascular19
Health State
TissuesTPM*
normal91
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor182
cervical tumor57
chondrosarcoma36
colorectal tumor115
esophageal tumor231
gastrointestinal tumor101
germ cell tumor49
glioma65
head and neck tumor209
kidney tumor87
leukemia74
liver tumor10
lung tumor38
lymphoma55
non-neoplasia62
ovarian tumor39
primitive neuroectodermal tumor of the CNS7
prostate cancer105
retinoblastoma21
skin tumor7
soft tissue/muscle tissue tumor7
uterine tumor144
Developmental Stage
TissuesTPM*
adult109
embryoid body57
blastocyst113
fetus98
infant42
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue14.5
adrenal gland16.3
appendix12.6
bone marrow9.6
cerebral cortex9
colon31.2
duodenum14.3
esophagus16.4
gallbladder14.4
heart muscle52.2
kidney48.9
liver11.5
lung35.4
lymph node28.6
ovary53.3
pancreas33.3
placenta19.9
prostate14.9
salivary gland19.2
skin73.1
small intestine12.9
spleen22.6
stomach21.3
testis31.8
thyroid gland36.7
urinary bladder11.3
Tissues
TissuesExpression level
appendixMedium
bone marrowLow
breastMedium
bronchusMedium
cerebral cortexMedium
cervix, uterineMedium
colonHigh
duodenumMedium
endometrium 1Medium
endometrium 2Low
epididymisLow
esophagusHigh
fallopian tubeHigh
gallbladderMedium
heart muscleHigh
kidneyHigh
liverMedium
lungLow
nasopharynxHigh
oral mucosaMedium
ovaryLow
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateMedium
rectumHigh
salivary glandLow
seminal vesicleMedium
skeletal muscleMedium
skin 1High
skin 2High
small intestineMedium
spleenLow
stomach 1Low
stomach 2High
testisMedium
thyroid glandHigh
tonsilMedium
urinary bladderMedium
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*608442, gene) Synaptic nuclear envelope protein 2; SYNE2OMIM
2(#612999, phenotype) Emery-dreifuss muscular dystrophy 5, autosomal dominant; EDMD5OMIM


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