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> Protein (NX_Q8WXH5)
Protein (NX_Q8WXH5)
Protein
Gene SymbolSOCS4 to neXtProt (NX_Q8WXH5)
DescriptionSuppressor of cytokine signaling 4
Chromosome14
Location14q22.2 (55493948 ~ 55516206) to Ensembl
Sequene Features : Isoforms 1, Variants 43, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of JAK-STAT cascade
.regulation of growth
.intracellular signal transduction
  + 4 more...
.protein kinase inhibitor activity .cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 43 0
2014-09-19protein level
1 35 0
2014-05-27protein level
1 35 0
2014-02-25protein level
1 33 0
2013-12-09protein level
1 25 0
2013-11-01protein level
1 24 0
2013-09-12protein level
1 24 0
2013-08-17protein level
1 24 0
2013-07-15protein level
1 18 0
2013-06-11protein level
1 18 0
2013-02-12protein level
1 7 0
2012-12-20protein level
1 7 0
2012-10-30protein level
1 9 0
2012-10-07protein level
1 9 0
2012-08-24protein level
1 9 0
2012-07-28protein level
1 9 0
2012-06-08protein level
1 11 0
2012-05-07protein level
1 8 0
2012-04-10protein level
1 8 0
2012-01-13protein level
1 8 0
2011-12-20protein level
1 8 0
2011-11-11protein level
1 8 0
2011-08-23protein level
1 8 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8WXH5-1
19 0 1 50590.6699
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-3942425,EBI-725515 FRS3  
  .fibroblast growth factor receptor signaling pathway
.signal transduction
.fibroblast growth factor receptor binding .plasma membrane
2 EBI-3942425,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
3 EBI-3942425,EBI-79893 PIK3R3  
  .phosphatidylinositol phosphorylation
.small molecule metabolic process
.regulation of phosphatidylinositol 3-kinase activity
  + 4 more...
.1-phosphatidylinositol-3-kinase regulator activity
.1-phosphatidylinositol-3-kinase activity
.phosphatidylinositol 3-kinase complex
.cytosol
4 EBI-3942425,EBI-2856326 RBP7  
  .N/A .retinol binding
.retinal binding
.transporter activity
.cytoplasm
5 EBI-3942425,EBI-2846068 PINK1  
  .positive regulation of ATP biosynthetic process
.negative regulation of reactive oxygen species metabolic process
.regulation of reactive oxygen species metabolic process
  + 58 more...
.C3HC4-type RING finger domain binding
.protein kinase B binding
.ubiquitin protein ligase binding
  + 7 more...
.astrocyte projection
.Lewy body
.perinuclear region of cytoplasm
  + 13 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder100
blood8
bone marrow41
brain17
connective tissue13
ear62
embryonic tissue32
esophagus148
eye9
intestine21
kidney28
liver29
lung14
lymph22
lymph node11
mammary gland19
mouth15
muscle47
pancreas4
parathyroid48
pharynx24
placenta21
prostate10
salivary gland49
skin9
stomach41
testis13
thymus25
thyroid21
umbilical cord72
uterus17
Health State
TissuesTPM*
normal18
bladder carcinoma113
breast (mammary gland) tumor21
chondrosarcoma12
colorectal tumor8
esophageal tumor173
gastrointestinal tumor16
germ cell tumor22
glioma18
head and neck tumor14
kidney tumor43
leukemia10
lung tumor9
lymphoma13
ovarian tumor26
pancreatic tumor9
primitive neuroectodermal tumor of the CNS39
prostate cancer19
skin tumor15
soft tissue/muscle tissue tumor15
uterine tumor11
Developmental Stage
TissuesTPM*
adult18
embryoid body28
blastocyst65
neonate32
fetus16
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue6.3
adrenal gland5.8
appendix12
bone marrow4.7
cerebral cortex5.9
colon6.5
duodenum5.4
esophagus6.9
gallbladder10.1
heart muscle5.2
kidney6.6
liver3.2
lung6.5
lymph node9.9
ovary3.5
pancreas2.3
placenta5.3
prostate5.9
salivary gland3.1
skin4.7
small intestine4.9
spleen7.8
stomach7
testis5.8
thyroid gland8.6
urinary bladder8.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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