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> Protein (NX_Q8WXU2)
Protein (NX_Q8WXU2)
Protein
Gene SymbolDYX1C1 to neXtProt (NX_Q8WXU2)
DescriptionDyslexia susceptibility 1 candidate gene 1 protein
Chromosome15
Location15q21.3 (55702723 ~ 55800432) to Ensembl
Sequene Features : Isoforms 3, Variants 64, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of proteasomal protein catabolic process
.inner dynein arm assembly
.outer dynein arm assembly
  + 4 more...
.estrogen receptor binding .plasma membrane
.cytoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 64 0
2014-09-19protein level
3 50 0
2014-05-27protein level
3 49 0
2014-02-25protein level
3 19 0
2013-12-09protein level
3 12 0
2013-11-01protein level
3 12 0
2013-09-12protein level
3 12 0
2013-08-17protein level
3 12 0
2013-07-15protein level
3 12 0
2013-06-11protein level
3 12 0
2013-02-12protein level
3 12 0
2012-12-20protein level
3 11 0
2012-10-30protein level
3 16 0
2012-10-07protein level
3 16 0
2012-08-24protein level
3 16 0
2012-07-28protein level
3 16 0
2012-06-08protein level
3 16 0
2012-05-07protein level
3 16 0
2012-04-10protein level
3 16 0
2012-01-13protein level
3 16 0
2011-12-20protein level
3 16 0
2011-11-11protein level
3 16 0
2011-08-23protein level
3 15 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8WXU2-1
4 14 0 48496.1739
NX_Q8WXU2-2
2 14 0 44172.7118
NX_Q8WXU2-3
0 14 0 44003.0043
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2946907,EBI-712001 GABARAP  
  .membrane fusion
.nucleophagy
.extrinsic apoptotic signaling pathway via death domain receptors
  + 5 more...
.GABA receptor binding
.beta-tubulin binding
.microtubule binding
.perinuclear region of cytoplasm
.cell body
.cytoplasmic vesicle
  + 13 more...
2 EBI-2946907,EBI-720116 GABARAPL2  
  .negative regulation of proteasomal protein catabolic process
.membrane fusion
.nucleophagy
  + 7 more...
.ATPase binding
.GABA receptor binding
.beta-tubulin binding
  + 2 more...
.cytoplasmic vesicle
.extrinsic component of membrane
.cytosol
  + 7 more...
3 EBI-2946907,EBI-715381 SPDL1  
  .cell division
.protein localization to kinetochore
.spindle checkpoint
  + 4 more...
.kinetochore binding
.enzyme binding
.cytosol
.microtubule organizing center
.nucleus
  + 2 more...
4 EBI-2946907,EBI-2603996 MAP1LC3C  
  .membrane fusion
.nucleophagy
.cellular response to nitrogen starvation
  + 2 more...
.microtubule binding .cytoplasmic vesicle
.organelle membrane
.extrinsic component of membrane
  + 6 more...
5 EBI-2946907,EBI-746969 GABARAPL1  
  .membrane fusion
.nucleophagy
.mitochondrion degradation
.autophagic vacuole assembly
.GABA receptor binding
.beta-tubulin binding
.Tat protein binding
.microtubule binding
.cell body
.dendrite cytoplasm
.dendrite membrane
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder66
bone13
brain4
connective tissue26
embryonic tissue4
eye4
kidney9
liver9
lung20
mammary gland13
pancreas14
pituitary gland60
prostate5
skin4
stomach10
testis27
thyroid42
Health State
TissuesTPM*
normal9
bladder carcinoma113
breast (mammary gland) tumor10
chondrosarcoma12
germ cell tumor3
glioma18
head and neck tumor14
kidney tumor14
pancreatic tumor19
prostate cancer9
skin tumor7
soft tissue/muscle tissue tumor31
Developmental Stage
TissuesTPM*
adult8
fetus8
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adrenal gland2.4
cerebral cortex2.1
esophagus1.6
gallbladder2.6
kidney3.2
lung4
ovary3.2
prostate2.5
testis9.2
thyroid gland8.5
urinary bladder1.5
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowLow
breastMedium
bronchusHigh
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Low
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleHigh
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverMedium
lymph nodeLow
nasopharynxHigh
oral mucosaMedium
ovaryMedium
pancreasHigh
parathyroid glandLow
placentaHigh
prostateLow
rectumMedium
salivary glandMedium
seminal vesicleLow
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleLow
soft tissue 2Low
spleenLow
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandHigh
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#127700, phenotype) Dyslexia, susceptibility to, 1; DYX1OMIM
2(*608706, gene) Dyslexia susceptibility 1 candidate 1; DYX1C1OMIM


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