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> Protein (NX_Q8WYA6)
Protein (NX_Q8WYA6)
Protein
Gene SymbolCTNNBL1 to neXtProt (NX_Q8WYA6)
DescriptionBeta-catenin-like protein 1
Chromosome20
Location20q11.23 (36322408 ~ 36500531) to Ensembl
Sequene Features : Isoforms 4, Variants 81, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of apoptotic process
.somatic diversification of immunoglobulins
.gene expression
  + 3 more...
.enzyme binding .membrane
.cytoplasm
.spliceosomal complex
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 81 8
2014-09-19protein level
4 65 8
2014-05-27protein level
3 65 8
2014-02-25protein level
3 65 8
2013-12-09protein level
3 52 8
2013-11-01protein level
3 50 6
2013-09-12protein level
3 50 5
2013-08-17protein level
3 50 5
2013-07-15protein level
3 29 3
2013-06-11protein level
3 29 3
2013-02-12protein level
3 14 7
2012-12-20protein level
3 12 7
2012-10-30protein level
3 12 7
2012-10-07protein level
3 12 3
2012-08-24protein level
3 11 3
2012-07-28protein level
3 11 3
2012-06-08protein level
3 15 3
2012-05-07protein level
3 10 3
2012-04-10protein level
3 10 3
2012-01-13protein level
3 8 3
2011-12-20protein level
3 8 3
2011-11-11protein level
3 8 3
2011-08-23protein level
3 8 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8WYA6-1
2 19 0 65131.9055
NX_Q8WYA6-2
1 16 0 43364.1625
NX_Q8WYA6-3
0 15 0 36079.4275
NX_Q8WYA6-4
0 19 0 61931.3989
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-748128,EBI-740738 LDOC1  
  .negative regulation of cell proliferation .N/A .nucleolus
.nucleus
2 EBI-748128,EBI-741753 NGFRAP1  
  .apoptotic signaling pathway
.neurotrophin TRK receptor signaling pathway
.regulation of cysteine-type endopeptidase activity involved in apoptotic process
  + 3 more...
.metal ion binding
.cysteine-type endopeptidase activator activity involved in apoptotic process
.cytosol
.cytoplasm
.nucleus
3 EBI-748128,EBI-632715 SNW1  
  .cellular response to retinoic acid
.positive regulation of vitamin D receptor signaling pathway
.regulation of vitamin D receptor signaling pathway
  + 19 more...
.SMAD binding
.poly(A) RNA binding
.retinoic acid receptor binding
  + 5 more...
.catalytic step 2 spliceosome
.nuclear matrix
.spliceosomal complex
  + 3 more...
4 EBI-748128,EBI-10258233 CATIP  
  .cilium organization
.actin filament polymerization
.calmodulin binding .actin cytoskeleton
.plasma membrane
.cytoplasm
.nucleus
5 EBI-748128,EBI-5278764 CDCA7L  
  .positive regulation of cell proliferation
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .cytoplasm
.nucleolus
.nucleus
6 EBI-748128,EBI-374880 CDC5L  
  .signal transduction involved in DNA damage checkpoint
.gene expression
.RNA splicing
  + 4 more...
.WD40-repeat domain binding
.poly(A) RNA binding
.chromatin binding
.DNA binding
.catalytic step 2 spliceosome
.nuclear speck
.membrane
  + 5 more...
7 EBI-748128,EBI-394607 MED4  
  .positive regulation of transcription, DNA-templated
.androgen receptor signaling pathway
.intracellular steroid hormone receptor signaling pathway
  + 3 more...
.thyroid hormone receptor binding
.vitamin D receptor binding
.ligand-dependent nuclear receptor transcription coactivator activity
  + 3 more...
.mediator complex
.membrane
.nucleoplasm
.nucleus
8 EBI-748128,EBI-632965 CREBZF  
  .regulation of sequence-specific DNA binding transcription factor activity
.negative regulation of transcription, DNA-templated
.negative regulation of gene expression, epigenetic
  + 2 more...
.sequence-specific DNA binding
.identical protein binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
9 EBI-748128,EBI-2803427 PRDM4  
  .neurotrophin TRK receptor signaling pathway
.negative regulation of cell cycle
.cell proliferation
  + 3 more...
.zinc ion binding
.methyltransferase activity
.DNA binding
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites100
bladder33
blood49
bone83
bone marrow61
brain73
cervix123
connective tissue187
embryonic tissue42
esophagus446
eye90
heart67
intestine81
kidney61
liver194
lung152
lymph361
lymph node89
mammary gland66
mouth30
muscle94
ovary177
pancreas70
pharynx294
placenta141
prostate52
salivary gland345
skin142
spleen243
stomach73
testis114
thymus112
tonsil352
umbilical cord72
uterus155
vascular38
Health State
TissuesTPM*
normal69
breast (mammary gland) tumor75
cervical tumor144
chondrosarcoma144
colorectal tumor106
esophageal tumor405
gastrointestinal tumor84
germ cell tumor182
glioma83
head and neck tumor67
kidney tumor87
leukemia74
liver tumor333
lung tumor175
lymphoma263
non-neoplasia93
ovarian tumor183
pancreatic tumor104
primitive neuroectodermal tumor of the CNS259
prostate cancer38
retinoblastoma193
skin tumor215
soft tissue/muscle tissue tumor247
uterine tumor122
Developmental Stage
TissuesTPM*
adult77
embryoid body28
blastocyst16
neonate96
fetus64
infant425
juvenile143
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue21.3
adrenal gland17.4
appendix26.9
bone marrow26.5
cerebral cortex17.8
colon24.5
duodenum17.8
esophagus26
gallbladder24.7
heart muscle24.3
kidney19.8
liver25.3
lung25.3
lymph node42
ovary25.3
pancreas7.8
placenta30.7
prostate21.5
salivary gland13.8
skin24.5
small intestine18.9
spleen48.3
stomach28.5
testis42.3
thyroid gland19.1
urinary bladder24.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*611537, gene) Catenin, beta-like, 1; CTNNBL1OMIM


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