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> Protein (NX_Q8WYH8)
Protein (NX_Q8WYH8)
Protein
Gene SymbolING5 to neXtProt (NX_Q8WYH8)
DescriptionInhibitor of growth protein 5
Chromosome2
Location2q37.3 (242641450 ~ 242668893) to Ensembl
Sequene Features : Isoforms 2, Variants 25, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of apoptotic signaling pathway
.negative regulation of growth
.positive regulation of transcription, DNA-templated
  + 7 more...
.methylated histone binding
.zinc ion binding
.chromatin binding
.MOZ/MORF histone acetyltransferase complex
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 25 5
2014-09-19protein level
2 16 5
2014-05-27protein level
2 16 6
2014-02-25protein level
2 15 5
2013-12-09protein level
2 10 5
2013-11-01protein level
2 9 5
2013-09-12protein level
2 9 5
2013-08-17protein level
2 9 5
2013-07-15protein level
2 5 4
2013-06-11protein level
2 5 4
2013-02-12protein level
2 1 10
2012-12-20protein level
2 1 10
2012-10-30protein level
2 3 10
2012-10-07protein level
2 3 5
2012-08-24protein level
2 3 5
2012-07-28protein level
2 3 5
2012-06-08protein level
2 4 5
2012-05-07protein level
2 3 5
2012-04-10protein level
2 3 5
2012-01-13protein level
2 0 5
2011-12-20protein level
2 0 5
2011-11-11protein level
2 0 3
2011-08-23protein level
2 0 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8WYH8-1
0 5 1 27732.6068
NX_Q8WYH8-2
0 5 1 25915.6417
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-488533,EBI-740220 HGS  
  .positive regulation of exosomal secretion
.protein localization to membrane
.membrane organization
  + 13 more...
.metal ion binding
.protein domain specific binding
.extracellular exosome
.intracellular membrane-bounded organelle
.multivesicular body membrane
  + 6 more...
2 EBI-488533,EBI-638194 ARFIP2  
  .regulation of Arp2/3 complex-mediated actin nucleation
.ruffle organization
.actin cytoskeleton organization
  + 3 more...
.phosphatidylinositol-4-phosphate binding
.Rac GTPase binding
.GTP-dependent protein binding
.GTP binding
.trans-Golgi network membrane
.cell cortex
.plasma membrane
  + 2 more...
3 EBI-488533,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
4 EBI-488533,EBI-1046751 ICA1  
  .neurotransmitter transport .N/A .synaptic vesicle membrane
.secretory granule membrane
.transport vesicle membrane
  + 4 more...
5 EBI-488533,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
6 EBI-488533,EBI-2837036 C3orf62  
  .N/A .N/A .N/A
7 EBI-488533,EBI-741200 NAV2  
  .vagus nerve development
.glossopharyngeal nerve development
.optic nerve development
  + 4 more...
.heparin binding
.ATP binding
.helicase activity
.nucleoplasm
.interstitial matrix
8 EBI-488533,EBI-455078 SMARCE1  
  .negative regulation of transcription, DNA-templated
.ATP-dependent chromatin remodeling
.metabolic process
  + 4 more...
.protein N-terminus binding
.ligand-dependent nuclear receptor binding
.N-acetyltransferase activity
  + 4 more...
.nBAF complex
.npBAF complex
.protein complex
  + 6 more...
9 EBI-488533,EBI-5278764 CDCA7L  
  .positive regulation of cell proliferation
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .cytoplasm
.nucleolus
.nucleus
10 EBI-488533,EBI-744115 CEP44  
  .N/A .N/A .midbody
.centrosome
.cytoplasm
.spindle pole
11 EBI-488533,EBI-2796167 JADE2  
  .SMAD protein signal transduction
.histone H4-K12 acetylation
.histone H4-K8 acetylation
  + 2 more...
.zinc ion binding .extracellular exosome
.nucleoplasm
.histone acetyltransferase complex
12 EBI-488533,EBI-10182361 MBIP  
  .histone H3 acetylation
.chromatin organization
.inactivation of MAPK activity involved in osmosensory signaling pathway
.identical protein binding
.protein kinase inhibitor activity
.cytoplasm
.nucleolus
.Ada2/Gcn5/Ada3 transcription activator complex
.nucleus
13 EBI-488533,EBI-747204 IKZF3  
  .regulation of lymphocyte differentiation
.regulation of B cell differentiation
.regulation of apoptotic process
  + 5 more...
.protein heterodimerization activity
.metal ion binding
.sequence-specific DNA binding
  + 2 more...
.plasma membrane
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
ascites25
bone27
bone marrow20
brain24
embryonic tissue28
eye33
heart11
intestine17
kidney28
liver34
lung50
lymph22
lymph node44
mammary gland13
mouth15
muscle28
ovary39
pancreas89
placenta21
prostate26
skin85
stomach20
testis48
thymus50
thyroid21
uterus34
Health State
TissuesTPM*
normal32
breast (mammary gland) tumor10
chondrosarcoma36
gastrointestinal tumor25
germ cell tumor22
glioma65
head and neck tumor14
kidney tumor14
leukemia21
lymphoma69
non-neoplasia20
ovarian tumor39
pancreatic tumor57
primitive neuroectodermal tumor of the CNS15
prostate cancer9
skin tumor143
soft tissue/muscle tissue tumor7
uterine tumor77
Developmental Stage
TissuesTPM*
adult21
embryoid body28
blastocyst32
fetus61
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue9.5
adrenal gland10.1
appendix11
bone marrow19.7
cerebral cortex10.7
colon8.8
duodenum10.6
esophagus8.4
gallbladder10.7
heart muscle6.8
kidney9.6
liver5
lung11.7
lymph node15.2
ovary22.5
pancreas7.3
placenta8.9
prostate15.2
salivary gland15
skin16.5
small intestine11.9
spleen11.4
stomach10.4
testis9.9
thyroid gland20.1
urinary bladder9.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*608525, gene) Inhibitor of growth 5; ING5OMIM


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