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> Protein (NX_Q8WYL5)
Protein (NX_Q8WYL5)
Protein
Gene SymbolSSH1 to neXtProt (NX_Q8WYL5)
DescriptionProtein phosphatase Slingshot homolog 1
Chromosome12
Location12q24.11 (109176466 ~ 109251366) to Ensembl
Sequene Features : Isoforms 5, Variants 143, PTMs 13 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to ATP
.regulation of axonogenesis
.regulation of cellular protein metabolic process
  + 5 more...
.protein tyrosine/serine/threonine phosphatase activity
.protein tyrosine phosphatase activity
.phosphoprotein phosphatase activity
  + 2 more...
.cleavage furrow
.midbody
.lamellipodium
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 143 13
2014-09-19protein level
5 108 13
2014-05-27protein level
5 107 13
2014-02-25protein level
5 107 13
2013-12-09protein level
5 83 13
2013-11-01protein level
5 80 13
2013-09-12protein level
5 80 13
2013-08-17protein level
5 80 13
2013-07-15protein level
5 56 12
2013-06-11protein level
5 56 12
2013-02-12protein level
5 31 17
2012-12-20protein level
5 30 17
2012-10-30protein level
5 34 17
2012-10-07protein level
5 34 7
2012-08-24protein level
5 23 7
2012-07-28protein level
5 23 7
2012-06-08protein level
5 29 7
2012-05-07protein level
5 29 7
2012-04-10protein level
5 29 7
2012-01-13protein level
5 21 7
2011-12-20protein level
5 21 7
2011-11-11protein level
5 21 3
2011-08-23protein level
5 6 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8WYL5-1
0 43 1 115438.4056
NX_Q8WYL5-2
0 29 1 77381.1858
NX_Q8WYL5-3
3 4 0 16684.0754
NX_Q8WYL5-4
1 29 1 80633.1517
NX_Q8WYL5-5
1 26 1 78927.8257
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1222387,EBI-352733 CFL1  
  .regulation of dendritic spine morphogenesis
.ephrin receptor signaling pathway
.negative regulation of cell size
  + 21 more...
.N/A .extracellular exosome
.ruffle membrane
.vesicle
  + 9 more...
2 EBI-1222387,EBI-359854 YWHAQ  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.membrane organization
  + 8 more...
.protein N-terminus binding .extracellular exosome
.protein complex
.cytoplasmic vesicle membrane
  + 4 more...
3 EBI-1222387,EBI-359815 YWHAB  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.membrane organization
  + 24 more...
.phosphoprotein binding
.phosphoserine binding
.histone deacetylase binding
  + 3 more...
.extracellular exosome
.perinuclear region of cytoplasm
.melanosome
  + 7 more...
4 EBI-1222387,EBI-444403 LIMK1  
  .positive regulation of stress fiber assembly
.negative regulation of ubiquitin-protein transferase activity
.ephrin receptor signaling pathway
  + 11 more...
.heat shock protein binding
.zinc ion binding
.ATP binding
  + 2 more...
.neuron projection
.focal adhesion
.cytosol
  + 2 more...
5 EBI-1222387,EBI-351152 CORO1B  
  .positive regulation of lamellipodium morphogenesis
.protein localization to cell leading edge
.actin filament branching
  + 10 more...
.Arp2/3 complex binding
.actin filament binding
.identical protein binding
.cell periphery
.extracellular exosome
.perinuclear region of cytoplasm
  + 9 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
bladder66
bone55
bone marrow20
brain30
connective tissue60
embryonic tissue61
eye158
heart33
intestine25
kidney42
liver29
lung50
lymph node55
mammary gland39
muscle18
pancreas46
placenta49
prostate42
skin109
stomach10
testis25
thymus25
thyroid64
tonsil352
trachea38
umbilical cord72
uterus90
Health State
TissuesTPM*
normal48
adrenal tumor79
breast (mammary gland) tumor53
chondrosarcoma84
colorectal tumor26
gastrointestinal tumor8
germ cell tumor34
glioma55
head and neck tumor22
kidney tumor87
leukemia31
liver tumor10
lung tumor48
non-neoplasia31
pancreatic tumor28
primitive neuroectodermal tumor of the CNS31
prostate cancer28
retinoblastoma86
skin tumor167
soft tissue/muscle tissue tumor87
uterine tumor133
Developmental Stage
TissuesTPM*
adult49
embryoid body114
blastocyst48
fetus62
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue8.9
adrenal gland7.7
appendix10.6
bone marrow8
cerebral cortex7.9
colon8.1
duodenum5.2
esophagus9.5
gallbladder12.5
heart muscle10.1
kidney7.7
liver3.3
lung12.4
lymph node7.7
ovary11
pancreas3.5
placenta9.4
prostate8.1
salivary gland4.3
skin6.7
small intestine5.6
spleen11.6
stomach6.7
testis8.4
thyroid gland8
urinary bladder11.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606778, gene) Slingshot, drosophila, homolog of, 1; SSH1OMIM


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