Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_Q8WYN0)
Protein (NX_Q8WYN0)
Protein
Gene SymbolATG4A to neXtProt (NX_Q8WYN0)
DescriptionCysteine protease ATG4A
ChromosomeX
LocationXq22.3 (107334898 ~ 107397901) to Ensembl
Sequene Features : Isoforms 4, Variants 46, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein delipidation
.nucleophagy
.protein processing
  + 6 more...
.cysteine-type peptidase activity
.cysteine-type endopeptidase activity
.cytosol
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 46 0
2014-09-19protein level
4 35 0
2014-05-27protein level
4 34 0
2014-02-25protein level
4 35 0
2013-12-09protein level
4 32 0
2013-11-01protein level
4 32 0
2013-09-12protein level
4 32 0
2013-08-17protein level
4 32 0
2013-07-15protein level
4 18 0
2013-06-11protein level
4 18 0
2013-02-12protein level
4 10 2
2012-12-20protein level
4 10 2
2012-10-30protein level
4 11 2
2012-10-07protein level
4 11 1
2012-08-24protein level
4 10 1
2012-07-28protein level
4 10 1
2012-06-08protein level
4 10 1
2012-05-07protein level
4 10 1
2012-04-10protein level
4 10 1
2012-01-13protein level
4 3 1
2011-12-20protein level
4 3 1
2011-11-11protein level
4 3 1
2011-08-23protein level
4 3 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8WYN0-1
0 15 0 45348.3203
NX_Q8WYN0-2
1 11 0 38575.7824
NX_Q8WYN0-3
0 12 0 36508.9148
NX_Q8WYN0-5
1 13 0 42425.7057
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-3044060,EBI-3919850 CDKL3  
  .dendrite extension
.positive regulation of dendrite morphogenesis
.negative regulation of axon extension
.cellular protein modification process
.ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.protein kinase activity
.cytoplasm
.nucleus
2 EBI-3044060,EBI-3464833 GABARAPL1  
  .membrane fusion
.nucleophagy
.mitochondrion degradation
.autophagic vacuole assembly
.GABA receptor binding
.beta-tubulin binding
.Tat protein binding
.microtubule binding
.cell body
.dendrite cytoplasm
.dendrite membrane
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
bladder33
blood40
bone27
bone marrow41
brain15
cervix41
connective tissue20
esophagus49
eye19
intestine30
kidney23
liver29
lung35
lymph135
mammary gland33
mouth30
muscle37
ovary9
pancreas18
pharynx73
pituitary gland60
placenta35
prostate26
skin18
spleen112
testis18
thymus12
tonsil58
trachea77
uterus38
vascular77
Health State
TissuesTPM*
normal28
breast (mammary gland) tumor53
chondrosarcoma24
colorectal tumor26
esophageal tumor57
germ cell tumor18
glioma18
head and neck tumor14
kidney tumor29
leukemia31
liver tumor20
lung tumor29
lymphoma138
non-neoplasia20
ovarian tumor13
primitive neuroectodermal tumor of the CNS55
prostate cancer19
soft tissue/muscle tissue tumor47
uterine tumor11
Developmental Stage
TissuesTPM*
adult27
fetus19
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue8.6
adrenal gland9.5
appendix9.6
bone marrow7.2
cerebral cortex3.8
colon13
duodenum12.4
esophagus10.6
gallbladder9.1
heart muscle11.1
kidney11.7
liver9.4
lung10
lymph node9.5
ovary3.5
pancreas8.2
placenta7.2
prostate6.6
salivary gland10.1
skin5.8
small intestine11.1
spleen8.9
stomach10.4
testis5.3
thyroid gland12.9
urinary bladder10.5
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowHigh
breastLow
bronchusLow
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusHigh
fallopian tubeMedium
gallbladderHigh
heart muscleMedium
hippocampusMedium
kidneyHigh
lateral ventricleLow
liverMedium
lungMedium
lymph nodeHigh
nasopharynxMedium
oral mucosaMedium
pancreasHigh
parathyroid glandMedium
placentaHigh
prostateMedium
rectumHigh
salivary glandHigh
seminal vesicleMedium
skeletal muscleHigh
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandMedium
tonsilHigh
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*300663, gene) Autophagy 4, s. cerevisiae, homolog of, a; ATG4AOMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center