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> Protein (NX_Q8WZ42)
Protein (NX_Q8WZ42)
Protein
Gene SymbolTTN to neXtProt (NX_Q8WZ42)
DescriptionTitin
Chromosome2
Location2q31.2 (179390716 ~ 179695529) to Ensembl
Sequene Features : Isoforms 13, Variants 6523, PTMs 77 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cardiac muscle contraction
.cardiac muscle tissue morphogenesis
.cardiac myofibril assembly
  + 18 more...
.structural molecule activity conferring elasticity
.muscle alpha-actinin binding
.actin filament binding
  + 13 more...
.extracellular exosome
.I band
.M band
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
13 6523 77
2014-09-19protein level
13 4601 77
2014-05-27protein level
13 4598 83
2014-02-25protein level
13 4545 83
2013-12-09protein level
13 3789 83
2013-11-01protein level
13 3687 83
2013-09-12protein level
13 3687 83
2013-08-17protein level
13 3689 83
2013-07-15protein level
12 2316 83
2013-06-11protein level
12 2316 83
2013-02-12protein level
11 1044 664
2012-12-20protein level
11 1221 664
2012-10-30protein level
11 1357 664
2012-10-07protein level
11 1357 80
2012-08-24protein level
11 1051 80
2012-07-28protein level
11 1049 80
2012-06-08protein level
11 365 80
2012-05-07protein level
11 365 80
2012-04-10protein level
11 365 80
2012-01-13protein level
8 362 80
2011-12-20protein level
8 362 80
2011-11-11protein level
8 362 79
2011-08-23protein level
8 361 79
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q8WZ42-1
0 1619 0 3813640.8681
NX_Q8WZ42-10
0 1313 0 3004875.035
NX_Q8WZ42-11
0 1574 0 3711274.7328
NX_Q8WZ42-12
43 1640 0 3992123.9096
NX_Q8WZ42-13
0 1624 0 3828670.1367
NX_Q8WZ42-2
1 1615 0 3803325.4
NX_Q8WZ42-3
0 1306 0 2991068.1503
NX_Q8WZ42-4
2 1573 0 3713700.9742
NX_Q8WZ42-5
2 1580 0 3650796.8323
NX_Q8WZ42-6
102 156 0 631172.1881
NX_Q8WZ42-7
0 1582 0 3732309.9022
NX_Q8WZ42-8
0 1626 0 3827447.7528
NX_Q8WZ42-9
0 1314 0 3012073.3092
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-681210,EBI-7843148 SYNM  
  .intermediate filament cytoskeleton organization .intermediate filament binding
.vinculin binding
.structural constituent of muscle
.structural constituent of cytoskeleton
.neurofilament cytoskeleton
.costamere
.membrane
  + 2 more...
2 EBI-681210,EBI-954089 TCAP  
  .cardiac muscle contraction
.cardiac muscle tissue morphogenesis
.cardiac myofibril assembly
  + 16 more...
.titin Z domain binding
.FATZ binding
.ion channel binding
  + 4 more...
.I band
.Z disc
.cytosol
3 EBI-681210,EBI-1223896 OBSL1  
  .cardiac myofibril assembly
.positive regulation of dendrite morphogenesis
.protein localization to Golgi apparatus
  + 4 more...
.cytoskeletal adaptor activity .3M complex
.perinuclear region of cytoplasm
.M band
  + 5 more...
4 EBI-681210,EBI-2799016 DYSF  
  .vesicle fusion
.plasma membrane repair
.calcium-dependent phospholipid binding
.phospholipid binding
.calcium ion binding
.extracellular exosome
.sarcolemma
.cytoplasmic vesicle membrane
  + 8 more...
5 EBI-681210,EBI-5655937 DNAJB5  
  .response to unfolded protein
.protein folding
.negative regulation of transcription from RNA polymerase II promoter
.chaperone binding .cytosol
.nucleus
6 EBI-681210,EBI-353877 ENO1  
  .canonical glycolysis
.negative regulation of transcription, DNA-templated
.small molecule metabolic process
  + 7 more...
.GTPase binding
.poly(A) RNA binding
.phosphopyruvate hydratase activity
  + 4 more...
.extracellular exosome
.M band
.membrane
  + 6 more...
7 EBI-681210,EBI-351710 ACTN1  
  .regulation of nucleic acid-templated transcription
.actin crosslink formation
.negative regulation of cellular component movement
  + 8 more...
.ion channel binding
.ligand-dependent nuclear receptor transcription coactivator activity
.vinculin binding
  + 3 more...
.extracellular exosome
.dendritic spine
.cell projection
  + 14 more...
8 EBI-681210,EBI-5655000 CAPN3  
  .self proteolysis
.protein localization to membrane
.cellular response to salt stress
  + 25 more...
.ligase regulator activity
.protein complex scaffold
.titin binding
  + 8 more...
.protein complex
.T-tubule
.Z disc
  + 6 more...
9 EBI-681210,EBI-1049657 NEB  
  .regulation of actin filament length
.muscle filament sliding
.somatic muscle development
.muscle organ development
.structural constituent of muscle .extracellular exosome
.Z disc
.actin cytoskeleton
.cytosol
10 EBI-681210,EBI-77797 ACTN2  
  .negative regulation of protein localization to cell surface
.positive regulation of potassium ion transmembrane transporter activity
.negative regulation of potassium ion transmembrane transporter activity
  + 13 more...
.titin Z domain binding
.FATZ binding
.protein dimerization activity
  + 8 more...
.extracellular exosome
.dendritic spine
.pseudopodium
  + 9 more...
11 EBI-681210,EBI-5357134 MYOM2  
  .muscle contraction .structural constituent of muscle .myosin filament
.M band
.mitochondrion
12 EBI-681210,EBI-397435 CALM2  
  .regulation of cell communication by electrical coupling involved in cardiac conduction
.regulation of high voltage-gated calcium channel activity
.positive regulation of protein serine/threonine kinase activity
  + 48 more...
.protein phosphatase activator activity
.ion channel binding
.protein serine/threonine kinase activator activity
  + 8 more...
.extracellular exosome
.vesicle
.growth cone
  + 10 more...
13 EBI-681210,EBI-5655165 MYBPH  
  .cell adhesion
.regulation of striated muscle contraction
.structural constituent of muscle .myosin filament
14 EBI-681210,EBI-5653200 MYBPC2  
  .muscle filament sliding
.cell adhesion
.structural constituent of muscle .myosin filament
.cytosol
15 EBI-681210,EBI-941850 OBSCN  
  .activation of mitophagy in response to mitochondrial depolarization
.apoptotic signaling pathway
.regulation of small GTPase mediated signal transduction
  + 6 more...
.metal ion binding
.titin binding
.ankyrin binding
  + 4 more...
.M band
.Z disc
.myofibril
.cytosol
16 EBI-681210,EBI-5661333 TRIM63  
  .cellular response to dexamethasone stimulus
.response to interleukin-1
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 5 more...
.titin binding
.ligase activity
.zinc ion binding
  + 2 more...
.M band
.Z disc
.microtubule
  + 2 more...
17 EBI-681210,EBI-748974 OPTN  
  .Golgi ribbon formation
.defense response to Gram-negative bacterium
.negative regulation of I-kappaB kinase/NF-kappaB signaling
  + 10 more...
.K63-linked polyubiquitin binding
.identical protein binding
.polyubiquitin binding
  + 2 more...
.recycling endosome
.perinuclear region of cytoplasm
.cytoplasmic membrane-bounded vesicle
  + 8 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
blood81
bone marrow20
brain17
connective tissue13
embryonic tissue65
eye38
heart2189
intestine8
kidney14
larynx2514
liver248
lung56
lymph node144
mammary gland39
mouth786
muscle4606
nerve772
pancreas18
pharynx466
pituitary gland60
placenta14
prostate68
skin9
testis20
thymus62
thyroid536
trachea19
uterus17
vascular38
Health State
TissuesTPM*
normal256
adrenal tumor79
breast (mammary gland) tumor21
germ cell tumor18
head and neck tumor575
kidney tumor14
leukemia190
lung tumor29
non-neoplasia51
prostate cancer9
retinoblastoma64
soft tissue/muscle tissue tumor79
uterine tumor33
Developmental Stage
TissuesTPM*
adult297
embryoid body42
blastocyst48
fetus341
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
esophagus3.2
heart muscle55.8
prostate5.9
Tissues
TissuesExpression level
adrenal glandMedium
appendixLow
bone marrowLow
breastLow
bronchusLow
cerebral cortexLow
cervix, uterineLow
colonLow
duodenumLow
esophagusLow
fallopian tubeLow
gallbladderLow
heart muscleHigh
hippocampusLow
kidneyLow
lateral ventricleLow
lymph nodeLow
nasopharynxLow
oral mucosaLow
parathyroid glandLow
placentaMedium
rectumLow
skeletal muscleHigh
skin 1Medium
skin 2Medium
small intestineLow
thyroid glandLow
tonsilMedium
urinary bladderLow
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*188840, gene) Titin; TTNOMIM
2(#600334, phenotype) Tibial muscular dystrophy, tardiveOMIM
3(#603689, phenotype) Hereditary myopathy with early respiratory failure; HMERFOMIM
4(#604145, phenotype) Cardiomyopathy, dilated, 1g; CMD1GOMIM
5(#608807, phenotype) Muscular dystrophy, limb-girdle, type 2j; LGMD2JOMIM
6(#611705, phenotype) Myopathy, early-onset, with fatal cardiomyopathyOMIM
7(#613765, phenotype) Cardiomyopathy, familial hypertrophic, 9; CMH9OMIM


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