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> Protein (NX_Q92569)
Protein (NX_Q92569)
Protein
Gene SymbolPIK3R3 to neXtProt (NX_Q92569)
DescriptionPhosphatidylinositol 3-kinase regulatory subunit gamma
Chromosome1
Location1p34.1 (46505812 ~ 46642160) to Ensembl
Sequene Features : Isoforms 3, Variants 53, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.phosphatidylinositol phosphorylation
.small molecule metabolic process
.regulation of phosphatidylinositol 3-kinase activity
  + 4 more...
.1-phosphatidylinositol-3-kinase regulator activity
.1-phosphatidylinositol-3-kinase activity
.phosphatidylinositol 3-kinase complex
.cytosol
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 53 1
2014-09-19protein level
3 44 1
2014-05-27protein level
3 44 2
2014-02-25protein level
3 44 2
2013-12-09protein level
3 31 2
2013-11-01protein level
3 31 2
2013-09-12protein level
3 31 3
2013-08-17protein level
3 31 3
2013-07-15protein level
3 19 3
2013-06-11protein level
3 19 3
2013-02-12protein level
3 9 9
2012-12-20protein level
3 12 9
2012-10-30protein level
3 16 9
2012-10-07protein level
3 16 3
2012-08-24protein level
3 11 3
2012-07-28protein level
3 11 3
2012-06-08protein level
3 12 3
2012-05-07protein level
3 12 3
2012-04-10protein level
3 12 3
2012-01-13protein level
3 11 3
2011-12-20protein level
3 11 3
2011-11-11protein level
3 11 2
2011-08-23protein level
3 11 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q92569-1
2 19 3 54413.7366
NX_Q92569-2
0 19 2 47317.9743
NX_Q92569-3
1 17 2 43437.1044
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-79893,EBI-725515 FRS3  
  .fibroblast growth factor receptor signaling pathway
.signal transduction
.fibroblast growth factor receptor binding .plasma membrane
2 EBI-79893,EBI-10700351 PPP1R12B  
  .positive regulation of catalytic activity
.small GTPase mediated signal transduction
.signal transduction
  + 3 more...
.phosphatase regulator activity
.enzyme activator activity
.cytosol
.nucleoplasm
3 EBI-79893,EBI-3914288 TSPAN2  
  .axon development
.oligodendrocyte differentiation
.myelination
  + 4 more...
.N/A .myelin sheath
.integral component of membrane
.plasma membrane
4 EBI-79893,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
5 EBI-79893,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
6 EBI-79893,EBI-1039152 MET  
  .positive regulation of endothelial cell chemotaxis
.negative regulation of hydrogen peroxide-mediated programmed cell death
.semaphorin-plexin signaling pathway
  + 22 more...
.protein phosphatase binding
.ATP binding
.hepatocyte growth factor-activated receptor activity
.protein tyrosine kinase activity
.integral component of membrane
.cell surface
.basal plasma membrane
  + 3 more...
7 EBI-79893,EBI-9834454 HCK  
  .positive regulation of actin cytoskeleton reorganization
.regulation of podosome assembly
.cellular response to peptide hormone stimulus
  + 28 more...
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.protein tyrosine kinase activity
.cell projection
.extrinsic component of cytoplasmic side of plasma membrane
.transport vesicle
  + 7 more...
8 EBI-79893,EBI-608057 AR  
  .negative regulation of extrinsic apoptotic signaling pathway
.regulation of establishment of protein localization to plasma membrane
.protein oligomerization
  + 21 more...
.ATPase binding
.protein dimerization activity
.transcription regulatory region DNA binding
  + 14 more...
.protein complex
.cytosol
.cytoplasm
  + 3 more...
9 EBI-79893,EBI-1379503 KIT  
  .melanocyte adhesion
.melanocyte migration
.cellular response to thyroid hormone stimulus
  + 69 more...
.metal ion binding
.protein homodimerization activity
.cytokine binding
  + 5 more...
.mast cell granule
.integral component of membrane
.cytoplasmic side of plasma membrane
  + 5 more...
10 EBI-79893,EBI-621482 SRC  
  .regulation of caveolin-mediated endocytosis
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway
  + 100 more...
.scaffold protein binding
.growth factor receptor binding
.hormone receptor binding
  + 14 more...
.extracellular exosome
.perinuclear region of cytoplasm
.neuron projection
  + 13 more...
11 EBI-79893,EBI-720706 ERBB3  
  .extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of protein tyrosine kinase activity
.neuron apoptotic process
  + 21 more...
.protein heterodimerization activity
.protein homodimerization activity
.identical protein binding
  + 5 more...
.receptor complex
.lateral plasma membrane
.apical plasma membrane
  + 4 more...
12 EBI-79893,EBI-518228 CBL  
  .positive regulation of receptor-mediated endocytosis
.negative regulation of apoptotic process
.negative regulation of epidermal growth factor receptor signaling pathway
  + 7 more...
.ubiquitin protein ligase activity
.ephrin receptor binding
.SH3 domain binding
  + 6 more...
.flotillin complex
.plasma membrane
.cytosol
  + 2 more...
13 EBI-79893,EBI-517592 IRS1  
  .positive regulation of glucose import in response to insulin stimulus
.JAK-STAT cascade involved in growth hormone signaling pathway
.phosphatidylinositol-mediated signaling
  + 29 more...
.phosphatidylinositol 3-kinase binding
.SH2 domain binding
.insulin-like growth factor receptor binding
  + 4 more...
.intracellular membrane-bounded organelle
.ciliary basal body
.caveola
  + 5 more...
14 EBI-79893,EBI-2116585 PIK3CA  
  .negative regulation of anoikis
.regulation of genetic imprinting
.negative regulation of fibroblast apoptotic process
  + 36 more...
.phosphatidylinositol-4,5-bisphosphate 3-kinase activity
.1-phosphatidylinositol-4-phosphate 3-kinase activity
.phosphatidylinositol 3-kinase activity
  + 5 more...
.lamellipodium
.phosphatidylinositol 3-kinase complex, class IA
.phosphatidylinositol 3-kinase complex
  + 3 more...
15 EBI-79893,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
16 EBI-79893,EBI-886 CRK  
  .ephrin receptor signaling pathway
.neurotrophin TRK receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 9 more...
.ephrin receptor binding
.SH2 domain binding
.extracellular exosome
.actin cytoskeleton
.plasma membrane
  + 3 more...
17 EBI-79893,EBI-750444 CRYBA2  
  .lens development in camera-type eye .structural constituent of eye lens .N/A
18 EBI-79893,EBI-702142 PTK2  
  .negative regulation of anoikis
.positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.regulation of substrate adhesion-dependent cell spreading
  + 56 more...
.SH2 domain binding
.protein kinase binding
.JUN kinase binding
  + 7 more...
.extrinsic component of cytoplasmic side of plasma membrane
.lamellipodium
.apical plasma membrane
  + 9 more...
19 EBI-79893,EBI-517684 GAB1  
  .interleukin-6-mediated signaling pathway
.labyrinthine layer development
.phosphatidylinositol-mediated signaling
  + 13 more...
.SH3/SH2 adaptor activity
.signal transducer activity
.cytosol
20 EBI-79893,EBI-10691507 PLEKHS1  
  .N/A .N/A .N/A
21 EBI-79893,EBI-5280499 ARL6IP4  
  .RNA splicing
.mRNA processing
.poly(A) RNA binding .nuclear speck
.nucleolus
.nucleus
22 EBI-79893,EBI-527784 OTUD7B  
  .negative regulation of protein localization to nucleus
.protein K48-linked deubiquitination
.protein K63-linked deubiquitination
  + 5 more...
.Lys48-specific deubiquitinase activity
.zinc ion binding
.cysteine-type peptidase activity
  + 2 more...
.cytoplasm
.nucleus
23 EBI-79893,EBI-375446 ABI1  
  .lamellipodium morphogenesis
.vascular endothelial growth factor receptor signaling pathway
.innate immune response
  + 10 more...
.protein complex binding
.protein tyrosine kinase activator activity
.cytoskeletal protein binding
.extracellular exosome
.postsynaptic membrane
.SCAR complex
  + 10 more...
24 EBI-79893,EBI-1569256 WDFY3  
  .aggrephagy
.positive regulation of macroautophagy
.endosomal transport
.metal ion binding
.1-phosphatidylinositol binding
.beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
.extrinsic component of autophagic vacuole membrane
.nuclear membrane
.extrinsic component of membrane
  + 5 more...
25 EBI-79893,EBI-448457 PELI3  
  .negative regulation of extrinsic apoptotic signaling pathway
.protein K63-linked ubiquitination
.positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
  + 7 more...
.ligase activity
.ubiquitin-protein transferase activity
.cytosol
26 EBI-79893,EBI-8487781 WBSCR27  
  .N/A .N/A .N/A
27 EBI-79893,EBI-3867416 OLIG1  
  .neuron fate commitment
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.DNA binding .nucleus
28 EBI-79893,EBI-3942425 SOCS4  
  .negative regulation of JAK-STAT cascade
.regulation of growth
.intracellular signal transduction
  + 4 more...
.protein kinase inhibitor activity .cytoplasm
29 EBI-79893,EBI-2856326 RBP7  
  .N/A .retinol binding
.retinal binding
.transporter activity
.cytoplasm
30 EBI-79893,EBI-2323209 SPSB2  
  .intracellular signal transduction
.protein ubiquitination
.N/A .cytoplasm
31 EBI-79893,EBI-490630 SH2D2A  
  .vascular endothelial growth factor receptor signaling pathway
.cell differentiation
.positive regulation of signal transduction
  + 3 more...
.SH3/SH2 adaptor activity .cytosol
.cytoplasm
32 EBI-79893,EBI-10693102 PARD6A  
  .tight junction assembly
.cell division
.cell-cell junction maintenance
  + 5 more...
.GTP-dependent protein binding
.Rho GTPase binding
.transcription factor binding
.apical part of cell
.protein complex
.cell cortex
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
bladder334
blood8
brain56
cervix41
connective tissue13
embryonic tissue32
eye57
heart67
intestine34
kidney4
larynx42
liver29
lung23
lymph22
mammary gland119
mouth136
muscle216
ovary59
pancreas14
pharynx98
placenta10
prostate68
salivary gland49
skin71
spleen93
stomach31
testis140
thymus25
thyroid257
trachea115
uterus86
vascular38
Health State
TissuesTPM*
normal57
bladder carcinoma170
breast (mammary gland) tumor139
cervical tumor57
colorectal tumor35
gastrointestinal tumor33
germ cell tumor102
glioma55
head and neck tumor171
kidney tumor14
leukemia10
lung tumor9
lymphoma13
non-neoplasia10
ovarian tumor65
primitive neuroectodermal tumor of the CNS23
prostate cancer77
skin tumor87
soft tissue/muscle tissue tumor79
uterine tumor55
Developmental Stage
TissuesTPM*
adult66
embryoid body71
blastocyst16
fetus70
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue17
adrenal gland11.1
appendix8
cerebral cortex11
colon6.4
duodenum3.9
esophagus9.5
gallbladder16.1
heart muscle15.6
kidney9.9
liver1.5
lung10.5
lymph node7.3
ovary2.3
pancreas2.3
placenta6.1
prostate7.4
salivary gland7.3
skin2
small intestine3.8
spleen10.2
stomach3.6
testis48.7
thyroid gland15.4
urinary bladder18.8
Tissues
TissuesExpression level
adrenal glandMedium
appendixLow
bone marrowMedium
breastHigh
bronchusHigh
cerebellumLow
cerebral cortexHigh
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisLow
fallopian tubeMedium
gallbladderMedium
hippocampusHigh
kidneyHigh
lateral ventricleMedium
liverLow
lungMedium
lymph nodeHigh
nasopharynxMedium
oral mucosaLow
pancreasHigh
parathyroid glandMedium
placentaMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skin 1High
skin 2Medium
small intestineLow
soft tissue 1Low
soft tissue 2Low
spleenMedium
stomach 1High
stomach 2Medium
testisHigh
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606076, gene) Phosphatidylinositol 3-kinase, regulatory subunit 3; PIK3R3OMIM


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