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> Protein (NX_Q92597)
Protein (NX_Q92597)
Protein
Gene SymbolNDRG1 to neXtProt (NX_Q92597)
DescriptionProtein NDRG1
Chromosome8
Location8q24.22 (134249414 ~ 134314265) to Ensembl
Sequene Features : Isoforms 3, Variants 61, PTMs 15 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of spindle checkpoint
.cellular response to hypoxia
.mast cell activation
  + 3 more...
.cadherin binding
.gamma-tubulin binding
.Rab GTPase binding
.microtubule binding
.extracellular exosome
.recycling endosome membrane
.perinuclear region of cytoplasm
  + 8 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 61 15
2014-09-19protein level
3 49 15
2014-05-27protein level
3 49 15
2014-02-25protein level
3 48 15
2013-12-09protein level
3 34 15
2013-11-01protein level
3 34 15
2013-09-12protein level
3 34 16
2013-08-17protein level
3 34 16
2013-07-15protein level
3 25 15
2013-06-11protein level
3 25 15
2013-02-12protein level
3 13 43
2012-12-20protein level
1 14 15
2012-10-30protein level
1 15 15
2012-10-07protein level
1 15 17
2012-08-24protein level
1 9 17
2012-07-28protein level
1 9 17
2012-06-08protein level
1 10 17
2012-05-07protein level
1 10 17
2012-04-10protein level
1 10 17
2012-01-13protein level
1 6 17
2011-12-20protein level
1 6 17
2011-11-11protein level
1 6 15
2011-08-23protein level
1 6 14
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q92597-1
3 13 0 42807.604
NX_Q92597-2
0 13 0 35497.9509
NX_Q92597-3
1 12 0 33628.1742
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-716486,EBI-353208 XRCC6  
  .establishment of integrated proviral latency
.cellular response to X-ray
.cellular hyperosmotic salinity response
  + 16 more...
.5'-deoxyribose-5-phosphate lyase activity
.poly(A) RNA binding
.transcription regulatory region DNA binding
  + 7 more...
.nonhomologous end joining complex
.Ku70:Ku80 complex
.membrane
  + 6 more...
2 EBI-716486,EBI-355947 CANX  
  .clathrin-mediated endocytosis
.chaperone-mediated protein folding
.synaptic vesicle endocytosis
  + 9 more...
.poly(A) RNA binding
.carbohydrate binding
.calcium ion binding
.integral component of lumenal side of endoplasmic reticulum membrane
.extracellular exosome
.ER-mitochondrion membrane contact site
  + 13 more...
3 EBI-10278703,EBI-2896123 AK6  
  .nucleotide phosphorylation .ATPase activity
.ATP binding
.adenylate kinase activity
.membrane
.Cajal body
.nucleoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue388
adrenal gland30
ascites125
bladder33
blood8
bone13
bone marrow184
brain16
cervix103
connective tissue20
ear62
embryonic tissue4
esophagus49
eye43
heart55
intestine21
kidney28
larynx42
liver29
lung23
lymph node22
mammary gland19
mouth166
muscle37
nerve450
ovary246
pancreas126
parathyroid97
pharynx294
pituitary gland121
placenta272
prostate1202
skin270
spleen468
stomach271
testis213
thymus2358
thyroid214
trachea444
umbilical cord145
uterus323
vascular793
Health State
TissuesTPM*
normal602
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor214
cervical tumor289
chondrosarcoma398
colorectal tumor106
esophageal tumor1043
gastrointestinal tumor185
germ cell tumor60
glioma307
head and neck tumor5402
kidney tumor827
leukemia201
liver tumor145
lung tumor506
non-neoplasia1138
ovarian tumor275
pancreatic tumor190
primitive neuroectodermal tumor of the CNS78
prostate cancer298
retinoblastoma43
skin tumor103
soft tissue/muscle tissue tumor55
uterine tumor177
Developmental Stage
TissuesTPM*
adult58
embryoid body14
blastocyst65
neonate708
fetus21
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue143.6
adrenal gland78.4
appendix54.7
bone marrow60.3
cerebral cortex74
colon157.1
duodenum198.2
esophagus231.2
gallbladder91.7
heart muscle50.8
kidney240
liver29.8
lung113
lymph node42.8
ovary110.8
pancreas25.2
placenta112.9
prostate321.6
salivary gland70
skin199.6
small intestine214.1
spleen39.6
stomach148.9
testis42.1
thyroid gland47.1
urinary bladder66.7
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowMedium
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverHigh
lungMedium
lymph nodeLow
nasopharynxHigh
oral mucosaMedium
ovaryHigh
pancreasHigh
parathyroid glandHigh
placentaMedium
prostateHigh
rectumHigh
salivary glandMedium
seminal vesicleHigh
skin 1Medium
skin 2High
small intestineHigh
smooth muscleLow
soft tissue 1Medium
soft tissue 2Medium
spleenLow
stomach 1High
stomach 2High
testisHigh
thyroid glandMedium
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#601455, phenotype) Charcot-marie-tooth disease, type 4d; CMT4DOMIM
2(*605262, gene) Nmyc downstream-regulated gene 1; NDRG1OMIM
3prostateCGP


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