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> Protein (NX_Q92608)
Protein (NX_Q92608)
Protein
Gene SymbolDOCK2 to neXtProt (NX_Q92608)
DescriptionDedicator of cytokinesis protein 2
Chromosome5
Location5q35.1 (169064251 ~ 169510386) to Ensembl
Sequene Features : Isoforms 2, Variants 401, PTMs 28 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of phagocytosis
.regulation of defense response to virus by virus
.alpha-beta T cell proliferation
  + 12 more...
.T cell receptor binding
.Rac guanyl-nucleotide exchange factor activity
.extracellular exosome
.membrane
.endomembrane system
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 401 28
2014-09-19protein level
2 302 28
2014-05-27protein level
2 300 28
2014-02-25protein level
2 300 28
2013-12-09protein level
2 271 29
2013-11-01protein level
2 251 23
2013-09-12protein level
2 251 24
2013-08-17protein level
2 251 24
2013-07-15protein level
2 154 8
2013-06-11protein level
2 154 8
2013-02-12protein level
2 66 13
2012-12-20protein level
2 65 13
2012-10-30protein level
2 70 13
2012-10-07protein level
2 70 11
2012-08-24protein level
2 68 11
2012-07-28protein level
2 68 11
2012-06-08protein level
2 71 11
2012-05-07protein level
2 38 11
2012-04-10protein level
2 38 11
2012-01-13protein level
2 16 11
2011-12-20protein level
2 16 11
2011-11-11protein level
2 16 11
2011-08-23protein level
2 16 11
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q92608-1
72 14 2 211811.1486
NX_Q92608-2
4 14 0 38435.7115
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-448771,EBI-740019 PLSCR1  
  .positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
.regulation of Fc receptor mediated stimulatory signaling pathway
.defense response to virus
  + 11 more...
.CD4 receptor binding
.enzyme binding
.phospholipid scramblase activity
  + 5 more...
.extracellular exosome
.membrane raft
.extracellular matrix
  + 7 more...
2 EBI-448771,EBI-748961 CCNDBP1  
  .regulation of cell cycle
.cell cycle
.N/A .cytoplasm
.nucleoplasm
.nucleus
3 EBI-448771,EBI-3958099 KRTAP5-9  
  .epidermis development .N/A .keratin filament
4 EBI-448771,EBI-740098 TRIM23  
  .positive regulation of catalytic activity
.protein ubiquitination
.viral process
.small GTPase mediated signal transduction
.identical protein binding
.GDP binding
.ligase activity
  + 5 more...
.extracellular exosome
.lysosomal membrane
.nucleus
.Golgi membrane
5 EBI-448771,EBI-10171774 KRTAP10-8  
  .N/A .N/A .keratin filament
6 EBI-448771,EBI-10172052 KRTAP10-9  
  .N/A .N/A .keratin filament
7 EBI-448771,EBI-304185 HNRNPK  
  .regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter
.positive regulation of receptor-mediated endocytosis
.positive regulation of transcription from RNA polymerase II promoter
  + 8 more...
.poly(A) RNA binding
.RNA binding
.single-stranded DNA binding
  + 2 more...
.catalytic step 2 spliceosome
.extracellular exosome
.cell projection
  + 7 more...
8 EBI-448771,EBI-413628 RAC1  
  .positive regulation of substrate adhesion-dependent cell spreading
.apoptotic signaling pathway
.ruffle assembly
  + 63 more...
.Rho GDP-dissociation inhibitor binding
.thioesterase binding
.enzyme binding
  + 2 more...
.extracellular exosome
.melanosome
.cytoplasmic ribonucleoprotein granule
  + 12 more...
9 EBI-448771,EBI-739580 CALCOCO2  
  .response to interferon-gamma
.viral process
.protein homodimerization activity .perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.membrane
  + 4 more...
10 EBI-448771,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
11 EBI-448771,EBI-742808 KHDRBS2  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.poly(U) RNA binding
.poly(A) binding
.nucleus
12 EBI-448771,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
13 EBI-448771,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
14 EBI-448771,EBI-724076 MDFI  
  .trophoblast giant cell differentiation
.embryonic skeletal system morphogenesis
.negative regulation of DNA binding
  + 6 more...
.N/A .cytoplasm
.nucleus
15 EBI-448771,EBI-10185730 KRTAP9-4  
  .N/A .N/A .keratin filament
16 EBI-448771,EBI-1044640 KRTAP9-2  
  .N/A .N/A .keratin filament
17 EBI-448771,EBI-10172511 KRTAP4-2  
  .N/A .N/A .keratin filament
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
blood139
bone27
brain10
connective tissue33
eye9
intestine12
kidney9
liver9
lung38
lymph225
lymph node233
mammary gland26
mouth30
muscle9
pancreas18
pharynx49
prostate10
spleen18
stomach10
testis2
thymus188
tonsil117
trachea38
Health State
TissuesTPM*
normal20
breast (mammary gland) tumor10
chondrosarcoma24
colorectal tumor26
germ cell tumor11
glioma9
head and neck tumor14
kidney tumor14
leukemia169
liver tumor10
lung tumor48
lymphoma207
non-neoplasia20
pancreatic tumor38
primitive neuroectodermal tumor of the CNS15
prostate cancer9
soft tissue/muscle tissue tumor31
Developmental Stage
TissuesTPM*
adult23
fetus30
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue9.6
adrenal gland5.5
appendix42.8
bone marrow49.6
cerebral cortex3.5
colon8.1
duodenum6.8
esophagus4.5
gallbladder14.6
heart muscle2.7
kidney1.8
liver4.5
lung15.6
lymph node68
ovary2.4
pancreas1.6
placenta6.8
prostate2.9
salivary gland4.4
skin2.4
small intestine9.7
spleen44.3
stomach11.1
testis3.5
thyroid gland2.7
urinary bladder19.5
Tissues
TissuesExpression level
appendixHigh
bone marrowHigh
lungMedium
lymph nodeHigh
skin 1Medium
spleenHigh
tonsilHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603122, gene) Dedicator of cytokinesis 2; DOCK2OMIM


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