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> Protein (NX_Q92624)
Protein (NX_Q92624)
Protein
Gene SymbolAPPBP2 to neXtProt (NX_Q92624)
DescriptionAmyloid protein-binding protein 2
Chromosome17
Location17q23.2 (58520520 ~ 58603580) to Ensembl
Sequene Features : Isoforms 1, Variants 50, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.intracellular transport
.metabolic process
.intracellular protein transport
.microtubule motor activity .cytoplasmic vesicle membrane
.microtubule associated complex
.microtubule
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 50 4
2014-09-19protein level
1 41 4
2014-05-27protein level
1 41 4
2014-02-25protein level
1 41 4
2013-12-09protein level
1 34 4
2013-11-01protein level
1 34 2
2013-09-12protein level
1 34 2
2013-08-17protein level
1 34 2
2013-07-15protein level
1 26 1
2013-06-11protein level
1 26 1
2013-02-12protein level
1 4 0
2012-12-20protein level
1 4 0
2012-10-30protein level
1 4 0
2012-10-07protein level
1 4 0
2012-08-24protein level
1 4 0
2012-07-28protein level
1 4 0
2012-06-08protein level
1 10 0
2012-05-07protein level
1 10 0
2012-04-10protein level
1 10 0
2012-01-13protein level
1 14 0
2011-12-20protein level
1 14 0
2011-11-11protein level
1 14 0
2011-08-23protein level
1 14 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q92624-1
26 0 0 66810.6792
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-743771,EBI-948266 KLF11  
  .cellular response to peptide
.positive regulation of apoptotic process
.negative regulation of cell proliferation
  + 4 more...
.metal ion binding
.transcription regulatory region DNA binding
.sequence-specific DNA binding transcription factor activity
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.nucleus
2 EBI-743771,EBI-10182857 ST8SIA5  
  .sialylation
.cellular protein metabolic process
.post-translational protein modification
  + 4 more...
.sialyltransferase activity
.alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity
.integral component of Golgi membrane
.Golgi membrane
3 EBI-743771,EBI-353467 GSTP1  
  .negative regulation of extrinsic apoptotic signaling pathway
.glutathione derivative biosynthetic process
.negative regulation of monocyte chemotactic protein-1 production
  + 27 more...
.nitric oxide binding
.dinitrosyl-iron complex binding
.S-nitrosoglutathione binding
  + 3 more...
.TRAF2-GSTP1 complex
.extracellular exosome
.vesicle
  + 7 more...
4 EBI-743771,EBI-749514 DPEP1  
  .cellular lactam catabolic process
.cellular response to nitric oxide
.cellular response to calcium ion
  + 11 more...
.modified amino acid binding
.metallodipeptidase activity
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
  + 4 more...
.extracellular exosome
.apical part of cell
.microvillus membrane
  + 6 more...
5 EBI-743771,EBI-2679622 PRKACB  
  .negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
.response to clozapine
.cellular response to glucagon stimulus
  + 26 more...
.ubiquitin protein ligase binding
.ATP binding
.cAMP-dependent protein kinase activity
.magnesium ion binding
.ciliary base
.extracellular exosome
.perinuclear region of cytoplasm
  + 5 more...
6 EBI-743771,EBI-389739 NFYA  
  .positive regulation of stem cell proliferation
.regulation of stem cell maintenance
.rhythmic process
  + 5 more...
.sequence-specific DNA binding transcription factor activity
.DNA binding
.core promoter sequence-specific DNA binding
.protein-DNA complex
.CCAAT-binding factor complex
.nucleoplasm
.nucleus
7 EBI-743771,EBI-1053240 AHCY  
  .small molecule metabolic process
.cellular nitrogen compound metabolic process
.S-adenosylmethionine cycle
  + 4 more...
.adenosylhomocysteinase activity .extracellular exosome
.melanosome
.cytosol
.cytoplasm
8 EBI-743771,EBI-356933 HSPA4  
  .chaperone-mediated protein complex assembly
.protein import into mitochondrial outer membrane
.response to unfolded protein
.ATP binding .extracellular exosome
.cytosol
.mitochondrion
9 EBI-743771,EBI-10206780 CLCN1  
  .regulation of anion transmembrane transport
.chloride transmembrane transport
.transmembrane transport
  + 4 more...
.chloride channel activity
.voltage-gated chloride channel activity
.sarcolemma
.chloride channel complex
.integral component of plasma membrane
.plasma membrane
10 EBI-743771,EBI-346375 WAS  
  .positive regulation of Arp2/3 complex-mediated actin nucleation
.negative regulation of cell motility
.T cell receptor signaling pathway
  + 15 more...
.phospholipase binding
.identical protein binding
.GTPase regulator activity
  + 2 more...
.extracellular exosome
.actin cytoskeleton
.vesicle membrane
  + 2 more...
11 EBI-743771,EBI-1383852 PRKAA2  
  .regulation of energy homeostasis
.membrane organization
.fatty acid homeostasis
  + 31 more...
.[acetyl-CoA carboxylase] kinase activity
.[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
.metal ion binding
  + 7 more...
.AMP-activated protein kinase complex
.cytosol
.cytoplasm
.nucleoplasm
12 EBI-743771,EBI-10216171 FXYD7  
  .regulation of sodium ion transmembrane transporter activity
.transmembrane transport
.ion transmembrane transport
.sodium channel regulator activity
.ion channel activity
.integral component of plasma membrane
.plasma membrane
13 EBI-743771,EBI-10216195 SELV  
  .cell redox homeostasis .selenium binding .N/A
14 EBI-743771,EBI-748380 CSNK1G2  
  .positive regulation of canonical Wnt signaling pathway
.protein autophosphorylation
.small molecule metabolic process
  + 8 more...
.peptide binding
.ATP binding
.protein serine/threonine kinase activity
.magnesium ion binding
.membrane
.cytosol
.nucleus
15 EBI-743771,EBI-395625 DCD  
  .defense response to fungus
.defense response to bacterium
.killing of cells of other organism
.poly(A) RNA binding
.peptidase activity
.extracellular exosome
.extracellular region
16 EBI-743771,EBI-726261 CDK16  
  .regulation of insulin secretion involved in cellular response to glucose stimulus
.neuron projection development
.growth hormone secretion
  + 3 more...
.ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.protein serine/threonine kinase activity
.neuron projection
.extrinsic component of cytoplasmic side of plasma membrane
.transport vesicle
  + 5 more...
17 EBI-743771,EBI-715766 TBL3  
  .intracellular signal transduction
.G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
.maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
.poly(A) RNA binding
.snoRNA binding
.receptor signaling protein activity
.Pwp2p-containing subcomplex of 90S preribosome
.small-subunit processome
.nucleolus
.nucleus
18 EBI-743771,EBI-2349801 FSTL1  
  .response to starvation
.BMP signaling pathway
.heparin binding
.calcium ion binding
.extracellular exosome
.extracellular space
.extracellular region
19 EBI-743771,EBI-716633 PPP1R8  
  .RNA phosphodiester bond hydrolysis
.negative regulation of catalytic activity
.RNA splicing
  + 5 more...
.ribonuclease E activity
.protein phosphatase type 1 regulator activity
.protein serine/threonine phosphatase inhibitor activity
  + 3 more...
.nuclear speck
.cytoplasm
.spliceosomal complex
  + 2 more...
20 EBI-743771,EBI-354324 DHRS2  
  .oxidation-reduction process
.negative regulation of apoptotic process
.myeloid dendritic cell differentiation
  + 4 more...
.carbonyl reductase (NADPH) activity .extracellular exosome
.mitochondrial matrix
.mitochondrion
  + 3 more...
21 EBI-743771,EBI-307369 IKBKE  
  .innate immune response
.positive regulation of I-kappaB kinase/NF-kappaB signaling
.NIK/NF-kappaB signaling
  + 9 more...
.IkappaB kinase activity
.ATP binding
.NF-kappaB-inducing kinase activity
.mitochondrial membrane
.PML body
.endosome membrane
  + 4 more...
22 EBI-743771,EBI-10232904 GALNT3  
  .cellular protein metabolic process
.post-translational protein modification
.protein O-linked glycosylation via threonine
  + 4 more...
.carbohydrate binding
.manganese ion binding
.calcium ion binding
.polypeptide N-acetylgalactosaminyltransferase activity
.extracellular exosome
.perinuclear region of cytoplasm
.Golgi cisterna membrane
  + 3 more...
23 EBI-743771,EBI-749186 RRS1  
  .ribosome biogenesis
.mitotic metaphase plate congression
.hematopoietic progenitor cell differentiation
.poly(A) RNA binding .endoplasmic reticulum
.nucleolus
.nucleus
.condensed nuclear chromosome
24 EBI-743771,EBI-1027005 TAF11  
  .RNA polymerase II transcriptional preinitiation complex assembly
.positive regulation by host of viral transcription
.viral process
  + 5 more...
.protein N-terminus binding
.thyroid hormone receptor binding
.vitamin D receptor binding
  + 2 more...
.Golgi apparatus
.transcription factor TFIID complex
.nucleoplasm
25 EBI-743771,EBI-2529266 COL24A1  
  .extracellular matrix organization
.hematopoietic progenitor cell differentiation
.extracellular matrix structural constituent .endoplasmic reticulum lumen
.collagen trimer
.proteinaceous extracellular matrix
.extracellular region
26 EBI-743771,EBI-2562802 CTC1  
  .replicative senescence
.hematopoietic stem cell proliferation
.bone marrow development
  + 9 more...
.single-stranded DNA binding .Stn1-Ten1 complex
.nucleus
.nuclear chromosome, telomeric region
27 EBI-743771,EBI-2690768 LONRF3  
  .N/A .zinc ion binding
.ATP-dependent peptidase activity
.N/A
28 EBI-743771,EBI-749741 SLC22A6  
  .anion transmembrane transport
.renal tubular secretion
.transmembrane transport
  + 5 more...
.chloride ion binding
.sodium-independent organic anion transmembrane transporter activity
.organic anion transmembrane transporter activity
.inorganic anion exchanger activity
.extracellular exosome
.protein complex
.basolateral plasma membrane
  + 3 more...
29 EBI-743771,EBI-10244057 C6orf226  
  .N/A .N/A .N/A
30 EBI-743771,EBI-10252512 ARMCX5  
  .N/A .N/A .N/A
31 EBI-743771,EBI-9477654 KLHL35  
  .N/A .N/A .N/A
32 EBI-743771,EBI-751100 KIF6  
  .metabolic process
.microtubule-based movement
.ATPase activity
.ATP binding
.microtubule motor activity
.microtubule
.kinesin complex
.cytoplasm
.male germ cell nucleus
33 EBI-743771,EBI-2340879 UBE2R2  
  .protein K48-linked ubiquitination
.proteasome-mediated ubiquitin-dependent protein catabolic process
.protein monoubiquitination
.ubiquitin conjugating enzyme activity
.ubiquitin protein ligase activity
.ubiquitin protein ligase binding
  + 4 more...
.cytoplasm
34 EBI-743771,EBI-3919450 PYROXD2  
  .N/A .oxidoreductase activity .N/A
35 EBI-743771,EBI-10267082 GCSAM  
  .negative regulation of lymphocyte migration
.regulation of B cell receptor signaling pathway
.myosin II binding
.protein kinase binding
.actin binding
.plasma membrane
.cytoplasm
36 EBI-743771,EBI-6381114 HIPK4  
  .regulation of signal transduction by p53 class mediator
.protein autophosphorylation
.peptidyl-serine phosphorylation
.histone phosphorylation
.ATP binding
.protein serine/threonine kinase activity
.cytoplasm
.nucleus
37 EBI-743771,EBI-2341619 RNF128  
  .negative regulation of cytokine biosynthetic process .ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.perinuclear region of cytoplasm
.integral component of membrane
.cytoskeleton
  + 3 more...
38 EBI-743771,EBI-2340642 RNF34  
  .negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
.regulation of oxygen metabolic process
.negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
  + 7 more...
.phosphatidylinositol phosphate binding
.ubiquitin protein ligase activity
.ubiquitin protein ligase binding
  + 3 more...
.nuclear speck
.endomembrane system
.plasma membrane
  + 3 more...
39 EBI-743771,EBI-744120 MUL1  
  .regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
.positive regulation of mitochondrial fission
.negative regulation of chemokine (C-C motif) ligand 5 production
  + 18 more...
.identical protein binding
.ubiquitin protein ligase binding
.SUMO transferase activity
  + 4 more...
.neuronal cell body
.integral component of mitochondrial outer membrane
.axon
  + 5 more...
40 EBI-743771,EBI-2564539 ERO1L  
  .intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
.release of sequestered calcium ion into cytosol
.chaperone mediated protein folding requiring cofactor
  + 12 more...
.oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
.oxidoreductase activity
.protein disulfide oxidoreductase activity
.protein disulfide isomerase activity
.intracellular membrane-bounded organelle
.membrane
.endoplasmic reticulum membrane
  + 2 more...
41 EBI-743771,EBI-742550 ZC3H10  
  .N/A .metal ion binding
.poly(A) RNA binding
.N/A
42 EBI-743771,EBI-10290841 FAM19A4  
  .regulation of sensory perception of pain
.regulation of membrane potential
.N/A .extracellular region
43 EBI-743771,EBI-746424 WDR24  
  .N/A .N/A .N/A
44 EBI-743771,EBI-745182 TCF25  
  .heart development
.transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
45 EBI-743771,EBI-751770 SYT11  
  .calcium ion-dependent exocytosis of neurotransmitter
.negative regulation of neurotransmitter secretion
.regulation of calcium ion-dependent exocytosis
  + 2 more...
.clathrin binding
.syntaxin binding
.calcium-dependent phospholipid binding
.calcium ion binding
.synaptic vesicle membrane
.cell junction
.synaptic vesicle
  + 2 more...
46 EBI-743771,EBI-2874661 C1orf50  
  .N/A .N/A .N/A
47 EBI-743771,EBI-2933255 SLC25A23  
  .urea homeostasis
.cellular response to calcium ion
.transmembrane transport
  + 4 more...
.calcium ion binding .integral component of membrane
.mitochondrial inner membrane
48 EBI-743771,EBI-4395497 ZNF747  
  .regulation of transcription, DNA-templated .nucleic acid binding .intracellular
49 EBI-743771,EBI-2510837 LANCL2  
  .negative regulation of transcription, DNA-templated
.positive regulation of abscisic acid-activated signaling pathway
.phosphatidylinositol-4-phosphate binding
.phosphatidylinositol-3-phosphate binding
.phosphatidylinositol-5-phosphate binding
  + 3 more...
.cortical actin cytoskeleton
.plasma membrane
.cytosol
  + 2 more...
50 EBI-743771,EBI-10316475 ANKRD10  
  .N/A .N/A .N/A
51 EBI-743771,EBI-1054215 UGGT2  
  .UDP-glucosylation
.cellular protein metabolic process
.post-translational protein modification
  + 2 more...
.UDP-glucose:glycoprotein glucosyltransferase activity .endoplasmic reticulum-Golgi intermediate compartment
.endoplasmic reticulum lumen
52 EBI-743771,EBI-10198848 LUZP4  
  .N/A .N/A .nucleus
53 EBI-743771,EBI-3916527 AK3  
  .UTP metabolic process
.ITP metabolic process
.GTP metabolic process
  + 3 more...
.nucleoside triphosphate adenylate kinase activity
.GTP binding
.ATP binding
.mitochondrial matrix
.mitochondrion
54 EBI-743771,EBI-2836773 CCNL1  
  .RNA processing
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.regulation of cyclin-dependent protein serine/threonine kinase activity
.N/A .nuclear speck
.nucleus
55 EBI-743771,EBI-7240490 SYNRG  
  .endocytosis
.intracellular protein transport
.N/A .AP-1 adaptor complex
.Golgi apparatus
.cytoplasm
56 EBI-743771,EBI-723376 CORO2B  
  .actin cytoskeleton organization .actin filament binding
.actin binding
.membrane
.actin cytoskeleton
.cytoplasm
57 EBI-743771,EBI-352851 LUC7L2  
  .mRNA splice site selection .poly(A) RNA binding
.enzyme binding
.mRNA binding
.nuclear speck
.U1 snRNP
58 EBI-743771,EBI-715760 SNX5  
  .retrograde transport, endosome to Golgi
.vesicle organization
.pinocytosis
.intracellular protein transport
.phosphatidylinositol binding
.dynactin binding
.tubular endosome
.macropinocytic cup
.early endosome membrane
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
ascites50
bladder66
blood65
bone55
bone marrow20
brain47
connective tissue87
embryonic tissue56
esophagus49
eye57
heart22
intestine21
kidney42
larynx85
liver48
lung17
lymph node66
mammary gland59
mouth15
muscle28
nerve64
pancreas74
pituitary gland60
placenta49
prostate26
salivary gland49
skin56
spleen18
stomach94
testis98
thyroid21
trachea57
uterus47
vascular19
Health State
TissuesTPM*
normal57
bladder carcinoma113
breast (mammary gland) tumor53
chondrosarcoma60
colorectal tumor35
esophageal tumor57
gastrointestinal tumor25
germ cell tumor37
glioma18
head and neck tumor29
kidney tumor43
leukemia74
liver tumor62
non-neoplasia20
pancreatic tumor28
primitive neuroectodermal tumor of the CNS23
prostate cancer28
retinoblastoma43
skin tumor71
soft tissue/muscle tissue tumor103
uterine tumor44
Developmental Stage
TissuesTPM*
adult47
embryoid body85
blastocyst32
fetus61
infant42
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue16
adrenal gland13.9
appendix16.3
bone marrow4.4
cerebral cortex18.7
colon11.9
duodenum9.1
esophagus17.2
gallbladder19.4
heart muscle7.4
kidney12.7
liver6.8
lung11.3
lymph node11.8
ovary22.3
pancreas7.2
placenta19.9
prostate14.9
salivary gland8.3
skin7.8
small intestine9.5
spleen12.3
stomach14.2
testis55.6
thyroid gland19.8
urinary bladder17.2
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*605324, gene) Amyloid beta precursor protein-binding protein 2; APPBP2OMIM


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