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> Protein (NX_Q92630)
Protein (NX_Q92630)
Protein
Gene SymbolDYRK2 to neXtProt (NX_Q92630)
DescriptionDual specificity tyrosine-phosphorylation-regulated kinase 2
Chromosome12
Location12q15 (68042118 ~ 68059186) to Ensembl
Sequene Features : Isoforms 2, Variants 69, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of NFAT protein import into nucleus
.positive regulation of glycogen biosynthetic process
.intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
  + 4 more...
.ubiquitin binding
.manganese ion binding
.ATP binding
  + 4 more...
.ribonucleoprotein complex
.cytoplasm
.nucleoplasm
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 69 7
2014-09-19protein level
2 47 7
2014-05-27protein level
2 47 7
2014-02-25protein level
2 47 7
2013-12-09protein level
2 42 7
2013-11-01protein level
2 41 7
2013-09-12protein level
2 41 7
2013-08-17protein level
2 41 7
2013-07-15protein level
2 28 7
2013-06-11protein level
2 28 7
2013-02-12protein level
2 11 10
2012-12-20protein level
2 11 10
2012-10-30protein level
2 12 6
2012-10-07protein level
2 12 3
2012-08-24protein level
2 11 3
2012-07-28protein level
2 11 3
2012-06-08protein level
2 15 3
2012-05-07protein level
2 11 3
2012-04-10protein level
2 11 3
2012-01-13protein level
2 13 3
2011-12-20protein level
2 13 3
2011-11-11protein level
2 13 3
2011-08-23protein level
2 10 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q92630-1
5 22 3 66609.1565
NX_Q92630-2
1 22 3 59676.5328
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-749432,EBI-714790 WDR62  
  .neurogenesis
.cerebral cortex development
.N/A .cytoplasm
.nucleoplasm
.nucleus
.spindle pole
2 EBI-749432,EBI-751145 SP100  
  .negative regulation of nucleic acid-templated transcription
.regulation of Fas signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
  + 27 more...
.chromo shadow domain binding
.protein homodimerization activity
.identical protein binding
  + 7 more...
.nuclear periphery
.PML body
.cytoplasm
  + 3 more...
3 EBI-749432,EBI-745305 IKZF1  
  .retina development in camera-type eye
.positive regulation of NK T cell differentiation
.Peyer's patch development
  + 17 more...
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.protein complex
.cytoplasm
.pericentric heterochromatin
.nucleus
4 EBI-749432,EBI-395708 ZBTB9  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
5 EBI-749432,EBI-739657 KXD1  
  .vesicle-mediated transport .N/A .BLOC-1 complex
6 EBI-749432,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
7 EBI-749432,EBI-3914009 DYRK4  
  .N/A .metal ion binding
.ATP binding
.protein tyrosine kinase activity
  + 2 more...
.intracellular membrane-bounded organelle
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder33
blood16
bone55
bone marrow41
brain21
embryonic tissue18
esophagus49
eye23
heart33
intestine68
kidney23
liver14
lung29
lymph node89
mammary gland46
mouth90
muscle65
nerve64
ovary68
pancreas56
pharynx24
pituitary gland60
placenta60
prostate5
skin37
spleen18
stomach94
testis16
thymus62
trachea19
uterus60
vascular58
Health State
TissuesTPM*
normal37
breast (mammary gland) tumor10
chondrosarcoma12
colorectal tumor106
esophageal tumor57
gastrointestinal tumor42
germ cell tumor34
glioma18
head and neck tumor37
kidney tumor43
leukemia31
liver tumor10
non-neoplasia31
ovarian tumor91
pancreatic tumor28
primitive neuroectodermal tumor of the CNS23
prostate cancer9
skin tumor55
soft tissue/muscle tissue tumor71
uterine tumor55
Developmental Stage
TissuesTPM*
adult46
embryoid body42
blastocyst16
neonate32
fetus41
infant170
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue5.2
adrenal gland4.8
appendix12.9
bone marrow8.3
cerebral cortex4.2
colon22.9
duodenum15.7
esophagus10.5
gallbladder15
heart muscle18.3
kidney5.4
liver2.1
lung8.4
lymph node19.1
ovary8.1
pancreas3.6
placenta11.2
prostate6.7
salivary gland3.2
skin4.9
small intestine22.3
spleen12.7
stomach17.5
testis5.8
thyroid gland7.2
urinary bladder11.6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603496, gene) Dual-specificity tyrosine phosphorylation-regulated kinase 2; DYRK2OMIM


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