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> Protein (NX_Q92743)
Protein (NX_Q92743)
Protein
Gene SymbolHTRA1 to neXtProt (NX_Q92743)
DescriptionSerine protease HTRA1
Chromosome10
Location10q26.13 (124221041 ~ 124274424) to Ensembl
Sequene Features : Isoforms 1, Variants 54, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.dentinogenesis
.negative regulation of defense response to virus
.positive regulation of epithelial cell proliferation
  + 4 more...
.serine-type peptidase activity
.serine-type endopeptidase activity
.extracellular exosome
.extracellular matrix
.cytosol
.extracellular space
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 54 0
2014-09-19protein level
1 34 0
2014-05-27protein level
1 34 0
2014-02-25protein level
1 32 0
2013-12-09protein level
1 31 0
2013-11-01protein level
1 30 0
2013-09-12protein level
1 30 0
2013-08-17protein level
1 30 0
2013-07-15protein level
1 21 0
2013-06-11protein level
1 21 0
2013-02-12protein level
1 12 0
2012-12-20protein level
1 10 0
2012-10-30protein level
1 10 0
2012-10-07protein level
1 10 0
2012-08-24protein level
1 10 0
2012-07-28protein level
1 10 0
2012-06-08protein level
1 12 0
2012-05-07protein level
1 9 0
2012-04-10protein level
1 9 0
2012-01-13protein level
1 7 0
2011-12-20protein level
1 7 0
2011-11-11protein level
1 7 0
2011-08-23protein level
1 7 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q92743-1
21 0 0 51254.4642
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland212
ascites50
blood8
bone363
bone marrow61
brain86
cervix206
connective tissue254
ear186
embryonic tissue18
esophagus49
eye181
heart290
intestine43
kidney66
larynx213
lung38
lymph node11
mammary gland125
mouth75
nerve128
ovary147
pancreas89
parathyroid291
pharynx24
pituitary gland544
placenta427
prostate47
salivary gland148
skin99
spleen18
stomach94
testis9
thyroid64
umbilical cord581
uterus60
vascular38
Health State
TissuesTPM*
normal119
adrenal tumor474
breast (mammary gland) tumor75
cervical tumor173
chondrosarcoma325
colorectal tumor26
esophageal tumor57
gastrointestinal tumor75
germ cell tumor15
glioma139
head and neck tumor104
kidney tumor72
leukemia10
lung tumor9
lymphoma13
non-neoplasia217
ovarian tumor118
pancreatic tumor85
prostate cancer28
skin tumor23
soft tissue/muscle tissue tumor55
uterine tumor44
Developmental Stage
TissuesTPM*
adult179
embryoid body42
neonate257
fetus114
infant42
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue133.6
adrenal gland79.4
appendix37.3
cerebral cortex195.2
colon47.6
duodenum18.9
esophagus56.7
gallbladder305.6
heart muscle89.5
kidney100.7
liver64.6
lung54.4
lymph node38.3
ovary351.5
pancreas26.5
placenta502.8
prostate62.9
salivary gland54
skin98.1
small intestine23.4
spleen35.6
stomach25.9
testis21
thyroid gland52.8
urinary bladder176.3
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowHigh
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1High
endometrium 2Medium
epididymisHigh
esophagusHigh
fallopian tubeMedium
gallbladderHigh
heart muscleHigh
hippocampusMedium
kidneyHigh
lateral ventricleMedium
liverMedium
lungHigh
lymph nodeMedium
oral mucosaMedium
ovaryHigh
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleMedium
skeletal muscleMedium
skin 1High
skin 2High
small intestineHigh
smooth muscleHigh
soft tissue 1High
soft tissue 2High
spleenHigh
stomach 1High
stomach 2High
testisMedium
thyroid glandHigh
tonsilHigh
urinary bladderMedium
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#600142, phenotype) Cerebral autosomal recessive arteriopathy with subcortical infarctsOMIM
2(*602194, gene) Htra serine peptidase 1; HTRA1OMIM
3(#610149, phenotype) Macular degeneration, age-related, 7; ARMD7OMIM


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