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> Protein (NX_Q92793)
Protein (NX_Q92793)
Protein
Gene SymbolCREBBP to neXtProt (NX_Q92793)
DescriptionCREB-binding protein
Chromosome16
Location16p13.3 (3775055 ~ 3930727) to Ensembl
Sequene Features : Isoforms 2, Variants 410, PTMs 30 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of protein stabilization
.regulation of cellular response to heat
.cellular response to hypoxia
  + 27 more...
.MRF binding
.acetyltransferase activity
.zinc ion binding
  + 14 more...
.nuclear body
.cytoplasm
.transcription factor complex
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 410 30
2014-09-19protein level
2 328 30
2014-05-27protein level
2 326 33
2014-02-25protein level
2 325 31
2013-12-09protein level
2 299 31
2013-11-01protein level
2 291 24
2013-09-12protein level
2 291 24
2013-08-17protein level
2 291 24
2013-07-15protein level
2 200 23
2013-06-11protein level
2 200 23
2013-02-12protein level
1 121 29
2012-12-20protein level
1 121 29
2012-10-30protein level
1 122 29
2012-10-07protein level
1 122 29
2012-08-24protein level
1 39 29
2012-07-28protein level
1 39 29
2012-06-08protein level
1 44 29
2012-05-07protein level
1 44 29
2012-04-10protein level
1 44 29
2012-01-13protein level
1 27 29
2011-12-20protein level
1 27 29
2011-11-11protein level
1 27 26
2011-08-23protein level
1 27 26
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q92793-1
2 67 19 265180.9435
NX_Q92793-2
1 67 18 260825.8405
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-81215,EBI-81266 IKBKB  
  .positive regulation of cation channel activity
.cellular response to tumor necrosis factor
.nucleotide-binding oligomerization domain containing signaling pathway
  + 32 more...
.scaffold protein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 5 more...
.membrane raft
.CD40 receptor complex
.cytoplasmic side of plasma membrane
  + 4 more...
2 EBI-81215,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
3 EBI-81215,EBI-608057 AR  
  .negative regulation of extrinsic apoptotic signaling pathway
.regulation of establishment of protein localization to plasma membrane
.protein oligomerization
  + 21 more...
.ATPase binding
.protein dimerization activity
.transcription regulatory region DNA binding
  + 14 more...
.protein complex
.cytosol
.cytoplasm
  + 3 more...
4 EBI-81215,EBI-711855 CREB1  
  .cellular response to zinc ion
.Type I pneumocyte differentiation
.lung saccule development
  + 45 more...
.cAMP response element binding
.enzyme binding
.transcription cofactor activity
  + 7 more...
.ATF4-CREB1 transcription factor complex
.nuclear euchromatin
.nucleoplasm
.nucleus
5 EBI-81215,EBI-296087 AKT1  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.response to insulin-like growth factor stimulus
.negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
  + 108 more...
.14-3-3 protein binding
.phosphatidylinositol-3,4-bisphosphate binding
.identical protein binding
  + 8 more...
.ciliary basal body
.microtubule cytoskeleton
.cell-cell junction
  + 7 more...
6 EBI-81215,EBI-491549 CTNNB1  
  .negative regulation of apoptotic signaling pathway
.positive regulation of DNA-templated transcription, initiation
.positive regulation of determination of dorsal identity
  + 126 more...
.euchromatin binding
.R-SMAD binding
.I-SMAD binding
  + 18 more...
.cell periphery
.beta-catenin-TCF7L2 complex
.extracellular exosome
  + 32 more...
7 EBI-81215,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
8 EBI-81215,EBI-958408 IFNAR2  
  .regulation of type I interferon-mediated signaling pathway
.type I interferon signaling pathway
.response to interferon-alpha
  + 6 more...
.type I interferon binding
.protein kinase binding
.type I interferon receptor activity
.integral component of plasma membrane
.plasma membrane
.extracellular space
.extracellular region
9 EBI-81215,EBI-356392 NAP1L1  
  .positive regulation of cell proliferation
.nucleosome assembly
.DNA replication
.poly(A) RNA binding .melanosome
.membrane
.nucleus
10 EBI-81215,EBI-1050386 COPS2  
  .negative regulation of nucleic acid-templated transcription
.skeletal muscle cell differentiation
.neuron differentiation
  + 5 more...
.signal transducer activity
.transcription corepressor activity
.COP9 signalosome
.cytoplasm
11 EBI-81215,EBI-73886 RELA  
  .negative regulation of extrinsic apoptotic signaling pathway
.positive regulation of miRNA metabolic process
.negative regulation of NIK/NF-kappaB signaling
  + 64 more...
.repressing transcription factor binding
.NF-kappaB binding
.protein N-terminus binding
  + 20 more...
.NF-kappaB complex
.I-kappaB/NF-kappaB complex
.cytosol
  + 4 more...
12 EBI-81215,EBI-1108782 FOXO1  
  .regulation of energy homeostasis
.regulation of reactive oxygen species metabolic process
.regulation of neural precursor cell proliferation
  + 38 more...
.protein phosphatase 2A binding
.sequence-specific DNA binding
.ubiquitin protein ligase binding
  + 4 more...
.cytosol
.mitochondrion
.cytoplasm
  + 2 more...
13 EBI-81215,EBI-2650369 IRF3  
  .programmed necrotic cell death
.macrophage apoptotic process
.cellular response to dsRNA
  + 28 more...
.transcription regulatory region DNA binding
.protein homodimerization activity
.identical protein binding
  + 3 more...
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
14 EBI-81215,EBI-78670 NCOA6  
  .labyrinthine layer blood vessel development
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 14 more...
.thyroid hormone receptor binding
.retinoid X receptor binding
.ligand-dependent nuclear receptor transcription coactivator activity
  + 4 more...
.intracellular membrane-bounded organelle
.histone methyltransferase complex
.transcription factor complex
  + 2 more...
15 EBI-81215,EBI-447269 HIF1A  
  .negative regulation of mesenchymal cell apoptotic process
.negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
.dopaminergic neuron differentiation
  + 62 more...
.Hsp90 protein binding
.protein heterodimerization activity
.sequence-specific DNA binding
  + 12 more...
.RNA polymerase II transcription factor complex
.motile cilium
.nuclear speck
  + 6 more...
16 EBI-81215,EBI-1046588 MTDH  
  .tight junction assembly
.positive regulation of protein kinase B signaling
.positive regulation of NF-kappaB transcription factor activity
  + 6 more...
.NF-kappaB binding
.poly(A) RNA binding
.double-stranded RNA binding
  + 2 more...
.perinuclear region of cytoplasm
.intercellular canaliculus
.nuclear membrane
  + 9 more...
17 EBI-81215,EBI-477430 KAT2B  
  .rhythmic process
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of cyclin-dependent protein serine/threonine kinase activity
  + 19 more...
.histone deacetylase binding
.protein complex binding
.protein kinase binding
  + 7 more...
.actomyosin
.I band
.A band
  + 5 more...
18 EBI-81215,EBI-77321 DAXX  
  .positive regulation of apoptotic signaling pathway
.positive regulation of neuron death
.negative regulation of transcription, DNA-templated
  + 13 more...
.androgen receptor binding
.protein N-terminus binding
.protein homodimerization activity
  + 10 more...
.SWI/SNF superfamily-type complex
.PML body
.cytosol
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland30
bladder33
blood73
bone27
bone marrow41
brain41
connective tissue46
ear186
embryonic tissue42
eye52
heart55
intestine43
kidney90
larynx639
liver19
lung77
lymph67
lymph node211
mammary gland271
mouth181
muscle28
nerve64
ovary68
pancreas60
pharynx147
placenta63
prostate52
salivary gland49
skin42
spleen18
stomach94
testis50
thymus62
thyroid150
trachea57
uterus30
Health State
TissuesTPM*
normal68
adrenal tumor79
bladder carcinoma170
breast (mammary gland) tumor247
chondrosarcoma36
colorectal tumor62
gastrointestinal tumor84
germ cell tumor53
glioma121
head and neck tumor239
kidney tumor58
leukemia127
lung tumor136
lymphoma41
non-neoplasia10
ovarian tumor91
pancreatic tumor47
primitive neuroectodermal tumor of the CNS31
prostate cancer19
retinoblastoma21
skin tumor31
soft tissue/muscle tissue tumor15
uterine tumor55
Developmental Stage
TissuesTPM*
adult105
embryoid body57
blastocyst32
fetus91
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue15.7
adrenal gland9.9
appendix18
bone marrow38.7
cerebral cortex12.9
colon14.1
duodenum10.3
esophagus14.1
gallbladder15.5
heart muscle10.8
kidney13
liver8.4
lung14.2
lymph node15
ovary35.1
pancreas11.4
placenta15.8
prostate14.4
salivary gland11.9
skin15.4
small intestine12.4
spleen21
stomach15
testis34.7
thyroid gland20.7
urinary bladder14.2
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowLow
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexMedium
cervix, uterineHigh
colonHigh
duodenumMedium
endometrium 1High
endometrium 2High
epididymisMedium
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusLow
kidneyMedium
lateral ventricleMedium
liverMedium
lungMedium
lymph nodeMedium
nasopharynxHigh
oral mucosaHigh
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaHigh
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2High
small intestineHigh
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandHigh
tonsilMedium
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#180849, phenotype) Rubinstein-taybi syndrome 1; RSTS1OMIM
2(*600140, gene) Creb-binding protein; CREBBPOMIM
3acute lymphocytic leukemia;acute myelogenous leukemia;diffuse large B-cell lymphoma;B-NHL;Rubinstein-Taybi syndromeCGP


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2014-2019 (C) Yonsei Proteome Research Center