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> Protein (NX_Q92831)
Protein (NX_Q92831)
Protein
Gene SymbolKAT2B to neXtProt (NX_Q92831)
DescriptionHistone acetyltransferase KAT2B
Chromosome3
Location3p24.3 (20081515 ~ 20195896) to Ensembl
Sequene Features : Isoforms 1, Variants 93, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.rhythmic process
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of cyclin-dependent protein serine/threonine kinase activity
  + 19 more...
.histone deacetylase binding
.protein complex binding
.protein kinase binding
  + 7 more...
.actomyosin
.I band
.A band
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 93 0
2014-09-19protein level
1 64 0
2014-05-27protein level
1 64 0
2014-02-25protein level
1 63 0
2013-12-09protein level
1 47 0
2013-11-01protein level
1 46 0
2013-09-12protein level
1 46 1
2013-08-17protein level
1 46 1
2013-07-15protein level
1 32 1
2013-06-11protein level
1 32 1
2013-02-12protein level
1 17 3
2012-12-20protein level
1 16 3
2012-10-30protein level
1 19 3
2012-10-07protein level
1 19 3
2012-08-24protein level
1 17 3
2012-07-28protein level
1 17 3
2012-06-08protein level
1 23 3
2012-05-07protein level
1 14 3
2012-04-10protein level
1 14 3
2012-01-13protein level
1 9 3
2011-12-20protein level
1 9 3
2011-11-11protein level
1 9 3
2011-08-23protein level
1 9 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q92831-1
31 0 5 92953.4501
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-477430,EBI-1001438 BUB1B  
  .regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.cell division
  + 10 more...
.ATP binding
.protein serine/threonine kinase activity
.protein kinase activity
.spindle midzone
.perinuclear region of cytoplasm
.cytosol
  + 7 more...
2 EBI-477430,EBI-1054489 USF1  
  .lipid homeostasis
.negative regulation of fibrinolysis
.carbon catabolite regulation of transcription
  + 11 more...
.protein heterodimerization activity
.sequence-specific DNA binding
.bHLH transcription factor binding
  + 6 more...
.transcription factor complex
.nucleoplasm
.nucleus
3 EBI-477430,EBI-447295 EP300  
  .negative regulation of protein stabilization
.regulation of cellular response to heat
.regulation of tubulin deacetylation
  + 40 more...
.pre-mRNA intronic binding
.androgen receptor binding
.nuclear hormone receptor binding
  + 17 more...
.cytoplasm
.transcription factor complex
.nucleoplasm
  + 2 more...
4 EBI-477430,EBI-1797287 TWIST1  
  .positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation
.cell proliferation involved in heart valve development
.negative regulation of double-strand break repair
  + 51 more...
.E-box binding
.bHLH transcription factor binding
.transcription factor binding
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.nucleus
5 EBI-477430,EBI-712521 TAF9  
  .negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
.response to interleukin-1
.positive regulation of response to cytokine stimulus
  + 13 more...
.C2H2 zinc finger domain binding
.transcription regulatory region DNA binding
.activating transcription factor binding
  + 3 more...
.MLL1 complex
.pre-snoRNP complex
.transcription factor TFTC complex
  + 4 more...
6 EBI-477430,EBI-447269 HIF1A  
  .negative regulation of mesenchymal cell apoptotic process
.negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
.dopaminergic neuron differentiation
  + 62 more...
.Hsp90 protein binding
.protein heterodimerization activity
.sequence-specific DNA binding
  + 12 more...
.RNA polymerase II transcription factor complex
.motile cilium
.nuclear speck
  + 6 more...
7 EBI-477430,EBI-477232 SIRT2  
  .positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia
.negative regulation of reactive oxygen species metabolic process
.ripoptosome assembly involved in necroptotic process
  + 55 more...
.NAD+ binding
.NAD-dependent histone deacetylase activity (H4-K16 specific)
.ubiquitin binding
  + 10 more...
.glial cell projection
.meiotic spindle
.mitotic spindle
  + 21 more...
8 EBI-477430,EBI-81215 CREBBP  
  .negative regulation of protein stabilization
.regulation of cellular response to heat
.cellular response to hypoxia
  + 27 more...
.MRF binding
.acetyltransferase activity
.zinc ion binding
  + 14 more...
.nuclear body
.cytoplasm
.transcription factor complex
  + 5 more...
9 EBI-477430,EBI-1802965 SIRT1  
  .positive regulation of cellular senescence
.negative regulation of cellular senescence
.negative regulation of peptidyl-lysine acetylation
  + 102 more...
.keratin filament binding
.NAD+ binding
.mitogen-activated protein kinase binding
  + 17 more...
.rDNA heterochromatin
.PML body
.mitochondrion
  + 10 more...
10 EBI-477430,EBI-744366 EHMT2  
  .histone H3-K27 methylation
.histone H3-K9 methylation
.histone lysine methylation
  + 6 more...
.C2H2 zinc finger domain binding
.histone methyltransferase activity (H3-K27 specific)
.histone methyltransferase activity (H3-K9 specific)
  + 4 more...
.intermediate filament cytoskeleton
.intracellular membrane-bounded organelle
.nucleoplasm
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
bladder66
blood16
bone13
bone marrow20
brain43
connective tissue26
ear124
embryonic tissue4
eye47
intestine12
kidney33
liver24
lung17
lymph node33
mammary gland26
muscle18
nerve193
ovary9
pancreas32
parathyroid97
pharynx24
pituitary gland60
placenta56
prostate21
salivary gland49
skin33
spleen37
stomach31
testis6
thymus62
trachea19
uterus8
vascular154
Health State
TissuesTPM*
normal39
adrenal tumor79
bladder carcinoma113
breast (mammary gland) tumor10
chondrosarcoma48
colorectal tumor17
gastrointestinal tumor25
germ cell tumor15
glioma65
non-neoplasia10
pancreatic tumor19
skin tumor31
uterine tumor11
Developmental Stage
TissuesTPM*
adult33
embryoid body14
fetus61
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue15.2
adrenal gland11.3
appendix19.6
bone marrow29.2
cerebral cortex30.1
colon11.8
duodenum17.8
esophagus27.6
gallbladder14.5
heart muscle27
kidney14.1
liver18.3
lung17.4
lymph node24.3
ovary27.6
pancreas8.4
placenta12.2
prostate14.1
salivary gland26.1
skin12.9
small intestine20.4
spleen20.3
stomach13
testis3.6
thyroid gland14.5
urinary bladder15
Tissues
TissuesExpression level
adrenal glandLow
appendixLow
bone marrowMedium
breastLow
bronchusMedium
cerebellumHigh
cerebral cortexMedium
cervix, uterineLow
colonMedium
duodenumMedium
endometrium 1Low
endometrium 2Low
epididymisMedium
esophagusLow
fallopian tubeMedium
gallbladderMedium
heart muscleLow
hippocampusMedium
kidneyMedium
lateral ventricleMedium
lungMedium
lymph nodeLow
nasopharynxMedium
oral mucosaLow
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaHigh
prostateMedium
rectumMedium
salivary glandHigh
seminal vesicleLow
skeletal muscleMedium
skin 1Medium
skin 2Low
small intestineMedium
smooth muscleLow
soft tissue 2Medium
spleenMedium
stomach 1High
stomach 2Medium
testisLow
thyroid glandHigh
tonsilMedium
urinary bladderHigh
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602303, gene) K(lysine) acetyltransferase 2b; KAT2BOMIM


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