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> Protein (NX_Q92835)
Protein (NX_Q92835)
Protein
Gene SymbolINPP5D to neXtProt (NX_Q92835)
DescriptionPhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
Chromosome2
Location2q37.1 (233924677 ~ 234116549) to Ensembl
Sequene Features : Isoforms 3, Variants 2, PTMs 10 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.leukocyte migration
.T cell receptor signaling pathway
.negative regulation of immune response
  + 22 more...
.phosphatidylinositol trisphosphate phosphatase activity
.inositol-polyphosphate 5-phosphatase activity
.membrane
.cytosol
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 2 10
2014-09-19protein level
3 2 10
2014-05-27protein level
3 2 10
2014-02-25protein level
3 2 10
2013-12-09protein level
3 2 10
2013-11-01protein level
3 2 10
2013-09-12protein level
3 2 11
2013-08-17protein level
3 2 11
2013-07-15protein level
3 2 11
2013-06-11protein level
3 2 11
2013-02-12protein level
3 2 24
2012-12-20protein level
3 2 24
2012-10-30protein level
3 2 24
2012-10-07protein level
3 2 8
2012-08-24protein level
3 2 8
2012-07-28protein level
3 2 8
2012-06-08protein level
3 4 8
2012-05-07protein level
3 4 8
2012-04-10protein level
3 4 8
2012-01-13protein level
3 4 8
2011-12-20protein level
3 5 8
2011-11-11protein level
3 5 8
2011-08-23protein level
3 5 7
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q92835-1
1 56 2 133208.7358
NX_Q92835-2
1 56 2 133109.6677
NX_Q92835-3
1 44 2 109224.9203
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1380477,EBI-722504 KHDRBS3  
  .spermatogenesis
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.poly(A) RNA binding
.RNA binding
.nucleoplasm
.nucleus
2 EBI-1380477,EBI-724784 FCGR2B  
  .regulation of immune response
.viral process
.signal transduction
.immune response
.N/A .integral component of membrane
.plasma membrane
3 EBI-1380477,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
4 EBI-1380477,EBI-10172052 KRTAP10-9  
  .N/A .N/A .keratin filament
5 EBI-1380477,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
6 EBI-1380477,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
7 EBI-1380477,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
8 EBI-1380477,EBI-346595 SH3KBP1  
  .negative regulation of epidermal growth factor receptor signaling pathway
.cell migration
.regulation of cell shape
  + 5 more...
.N/A .synapse
.neuron projection
.cytoplasmic vesicle membrane
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
blood106
bone13
bone marrow246
brain16
connective tissue6
eye43
heart44
intestine81
kidney37
lung41
lymph45
lymph node2128
mammary gland13
nerve64
pancreas9
pharynx49
placenta28
prostate21
skin9
spleen56
stomach10
testis6
thymus37
tonsil822
uterus25
vascular19
Health State
TissuesTPM*
normal81
chondrosarcoma12
colorectal tumor71
gastrointestinal tumor8
germ cell tumor22
glioma111
kidney tumor43
leukemia465
lung tumor9
lymphoma69
non-neoplasia20
pancreatic tumor9
retinoblastoma21
skin tumor15
soft tissue/muscle tissue tumor7
uterine tumor22
Developmental Stage
TissuesTPM*
adult34
neonate32
fetus48
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue19.2
adrenal gland10.3
appendix88.2
bone marrow94.9
cerebral cortex12.9
colon16.5
duodenum15.6
esophagus14
gallbladder30.1
heart muscle7.2
kidney7.2
liver8
lung29.8
lymph node151.1
ovary6.1
pancreas3.2
placenta32.4
prostate10.5
salivary gland71.4
skin12.4
small intestine22.9
spleen114.2
stomach24.6
testis7.7
thyroid gland8.6
urinary bladder40
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601582, gene) Inositol polyphosphate-5-phosphatase, 145-kd; INPP5DOMIM


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