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> Protein (NX_Q92838)
Protein (NX_Q92838)
Protein
Gene SymbolEDA to neXtProt (NX_Q92838)
DescriptionEctodysplasin-A
ChromosomeX
LocationXq13.1 (68835911 ~ 69259319) to Ensembl
Sequene Features : Isoforms 8, Variants 107, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of canonical Wnt signaling pathway
.trachea gland development
.hair follicle placode formation
  + 11 more...
.receptor binding .apical part of cell
.intracellular membrane-bounded organelle
.integral component of membrane
  + 7 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
8 107 2
2014-09-19protein level
8 99 2
2014-05-27protein level
8 99 2
2014-02-25protein level
8 99 2
2013-12-09protein level
8 94 2
2013-11-01protein level
8 94 2
2013-09-12protein level
8 94 2
2013-08-17protein level
8 94 2
2013-07-15protein level
8 85 2
2013-06-11protein level
8 85 2
2013-02-12protein level
8 74 6
2012-12-20protein level
8 72 6
2012-10-30protein level
8 75 6
2012-10-07protein level
8 75 2
2012-08-24protein level
8 75 2
2012-07-28protein level
8 75 2
2012-06-08protein level
8 69 2
2012-05-07protein level
8 69 2
2012-04-10protein level
8 68 2
2012-01-13protein level
8 67 2
2011-12-20protein level
8 67 2
2011-11-11protein level
8 67 2
2011-08-23protein level
8 67 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q92838-1
1 13 0 41267.6991
NX_Q92838-2
1 5 0 14038.8469
NX_Q92838-3
0 14 0 41039.5887
NX_Q92838-5
1 5 0 15087.4466
NX_Q92838-6
1 5 0 14788.2846
NX_Q92838-7
1 5 0 15572.5171
NX_Q92838-8
1 5 0 15433.6935
NX_Q92838-9
1 13 0 40724.4465
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-529425,EBI-3932027 MAL  
  .positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
.transmembrane transport
.apical protein localization
  + 5 more...
.structural constituent of myelin sheath
.peptidase activator activity involved in apoptotic process
.channel activity
.lipid binding
.membrane raft
.extrinsic component of membrane
.apical plasma membrane
  + 3 more...
2 EBI-529425,EBI-692836 PLN  
  .negative regulation of calcium ion import into sarcoplasmic reticulum
.regulation of relaxation of cardiac muscle
.negative regulation of calcium-transporting ATPase activity
  + 26 more...
.ATPase binding
.identical protein binding
.ATPase inhibitor activity
  + 2 more...
.calcium ion-transporting ATPase complex
.perinuclear region of cytoplasm
.sarcoplasmic reticulum membrane
  + 5 more...
3 EBI-529425,EBI-721179 ATP6V0C  
  .phagosome maturation
.transmembrane transport
.interaction with host
  + 8 more...
.proton-transporting ATPase activity, rotational mechanism
.proton-transporting ATP synthase activity, rotational mechanism
.ubiquitin protein ligase binding
.extracellular exosome
.proton-transporting V-type ATPase, V0 domain
.phagocytic vesicle membrane
  + 4 more...
4 EBI-529425,EBI-8646596 CYB561  
  .transmembrane transport
.electron transport chain
.metal ion binding
.transmembrane electron transfer carrier
.ferric-chelate reductase activity
.integral component of membrane
5 EBI-529425,EBI-3907816 EMP3  
  .bleb assembly
.cell growth
.negative regulation of cell proliferation
.cell death
.N/A .integral component of membrane
.plasma membrane
6 EBI-529425,EBI-10252783 NIPAL3  
  .N/A .magnesium ion transmembrane transporter activity .integral component of membrane
7 EBI-529425,EBI-6166686 GIMAP5  
  .negative regulation of lipid catabolic process
.negative regulation of T cell activation
.regulation of mitochondrial membrane permeability
  + 14 more...
.GTP binding .integral component of membrane
.lysosome
.mitochondrial outer membrane
8 EBI-529425,EBI-8652744 SEC22A  
  .vesicle fusion with Golgi apparatus
.protein transport
.ER to Golgi vesicle-mediated transport
.SNAP receptor activity
.transporter activity
.SNARE binding
.SNARE complex
.integral component of membrane
.endoplasmic reticulum membrane
9 EBI-529425,EBI-1044658 OSTC  
  .protein N-linked glycosylation via asparagine .N/A .integral component of membrane
.oligosaccharyltransferase complex
10 EBI-529425,EBI-8645574 DOLK  
  .cellular protein metabolic process
.post-translational protein modification
.dolichyl monophosphate biosynthetic process
  + 3 more...
.dolichol kinase activity .integral component of endoplasmic reticulum membrane
.endoplasmic reticulum membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain1
connective tissue13
embryonic tissue4
heart11
kidney9
lung5
muscle9
ovary9
prostate15
skin37
spleen56
testis4
thyroid42
uterus8
Health State
TissuesTPM*
normal4
chondrosarcoma24
head and neck tumor14
kidney tumor14
prostate cancer19
skin tumor63
uterine tumor22
Developmental Stage
TissuesTPM*
adult5
blastocyst16
fetus10
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue2.1
adrenal gland6.8
colon1.3
esophagus2
gallbladder2.4
heart muscle4.1
kidney3
lung2.5
ovary4.5
pancreas1.9
placenta1.6
prostate2.8
salivary gland1.4
skin2.6
spleen1.4
stomach1
testis1.3
thyroid gland7.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*300451, gene) Ectodysplasin a; EDAOMIM
2(#305100, phenotype) Ectodermal dysplasia 1, hypohidrotic, x-linked; XHEDOMIM
3(#313500, phenotype) Tooth agenesis, selective, x-linked, 1; STHAGX1OMIM


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