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> Protein (NX_Q92841)
Protein (NX_Q92841)
Protein
Gene SymbolDDX17 to neXtProt (NX_Q92841)
DescriptionProbable ATP-dependent RNA helicase DDX17
Chromosome22
Location22q13.1 (38879445 ~ 38903665) to Ensembl
Sequene Features : Isoforms 4, Variants 78, PTMs 16 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of skeletal muscle cell differentiation
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of intracellular estrogen receptor signaling pathway
  + 4 more...
.poly(A) RNA binding
.estrogen receptor binding
.RNA-dependent ATPase activity
  + 5 more...
.membrane
.cytoplasm
.nucleolus
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 78 16
2014-09-19protein level
4 48 16
2014-05-27protein level
4 48 20
2014-02-25protein level
4 48 18
2013-12-09protein level
4 43 18
2013-11-01protein level
4 40 13
2013-09-12protein level
4 40 13
2013-08-17protein level
4 40 13
2013-07-15protein level
4 28 6
2013-06-11protein level
4 28 6
2013-02-12protein level
4 11 37
2012-12-20protein level
4 10 37
2012-10-30protein level
4 11 37
2012-10-07protein level
4 11 10
2012-08-24protein level
4 5 10
2012-07-28protein level
4 4 10
2012-06-08protein level
4 0 9
2012-05-07protein level
4 0 9
2012-04-10protein level
4 0 9
2012-01-13protein level
4 0 9
2011-12-20protein level
4 1 9
2011-11-11protein level
4 1 5
2011-08-23protein level
4 1 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q92841-1
0 24 9 72325.7564
NX_Q92841-2
1 24 8 72495.8614
NX_Q92841-3
0 24 9 72510.8722
NX_Q92841-4
4 24 9 80221.7887
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-746012,EBI-308320 NFAT5  
  .regulation of calcineurin-NFAT signaling cascade
.positive regulation of transcription from RNA polymerase II promoter
.excretion
  + 3 more...
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.cytoplasm
.nucleus
2 EBI-746012,EBI-78473 ESR1  
  .cellular response to estradiol stimulus
.epithelial cell proliferation involved in mammary gland duct elongation
.mammary gland alveolus development
  + 33 more...
.ATPase binding
.identical protein binding
.estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
  + 14 more...
.transcriptionally active chromatin
.integral component of membrane
.membrane
  + 5 more...
3 EBI-746012,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
4 EBI-746012,EBI-351962 DDX5  
  .regulation of skeletal muscle cell differentiation
.intrinsic apoptotic signaling pathway by p53 class mediator
.regulation of androgen receptor signaling pathway
  + 13 more...
.androgen receptor binding
.poly(A) RNA binding
.pre-mRNA binding
  + 5 more...
.catalytic step 2 spliceosome
.extracellular exosome
.ribonucleoprotein complex
  + 5 more...
5 EBI-746012,EBI-1044059 YAP1  
  .negative regulation of extrinsic apoptotic signaling pathway
.negative regulation of stem cell differentiation
.negative regulation of nucleic acid-templated transcription
  + 24 more...
.transcription regulatory region DNA binding
.transcription corepressor activity
.transcription coactivator activity
  + 3 more...
.cell junction
.membrane
.cytosol
  + 4 more...
6 EBI-746012,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
7 EBI-5280703,EBI-301834 HDAC1  
  .histone H4 deacetylation
.histone H3 deacetylation
.fungiform papilla formation
  + 34 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.repressing transcription factor binding
.NF-kappaB binding
  + 17 more...
.protein complex
.NuRD complex
.Sin3 complex
  + 7 more...
8 EBI-746012,EBI-358049 BYSL  
  .cell proliferation
.female pregnancy
.cell adhesion
  + 2 more...
.poly(A) RNA binding .apical part of cell
.intracellular membrane-bounded organelle
.membrane
  + 3 more...
9 EBI-746012,EBI-81236 NCOA2  
  .positive regulation of transcription from RNA polymerase II promoter
.small molecule metabolic process
.cellular lipid metabolic process
  + 11 more...
.nuclear hormone receptor binding
.thyroid hormone receptor coactivator activity
.ligand-dependent nuclear receptor transcription coactivator activity
  + 5 more...
.cytoplasm
.nucleoplasm
.nucleus
10 EBI-746012,EBI-2514922 RBM15  
  .placenta blood vessel development
.ventricular septum morphogenesis
.spleen development
  + 4 more...
.poly(A) RNA binding
.nucleotide binding
.nuclear membrane
.nucleoplasm
11 EBI-746012,EBI-81196 NCOA3  
  .regulation of RNA biosynthetic process
.mammary gland branching involved in thelarche
.labyrinthine layer morphogenesis
  + 13 more...
.androgen receptor binding
.protein N-terminus binding
.thyroid hormone receptor binding
  + 7 more...
.extracellular exosome
.cytoplasm
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue699
adrenal gland333
ascites150
bladder334
blood425
bone251
bone marrow307
brain1
cervix206
connective tissue201
ear1118
embryonic tissue4
esophagus744
eye397
heart480
intestine370
kidney332
larynx468
liver253
lung343
lymph158
lymph node11
mammary gland238
mouth241
muscle84
nerve643
ovary285
pancreas285
parathyroid291
pharynx392
pituitary gland1331
placenta325
prostate348
salivary gland197
skin346
spleen206
stomach533
testis172
thymus250
thyroid772
tonsil58
trachea96
uterus435
vascular387
Health State
TissuesTPM*
normal1
adrenal tumor316
bladder carcinoma227
breast (mammary gland) tumor236
cervical tumor260
chondrosarcoma241
colorectal tumor302
esophageal tumor869
gastrointestinal tumor253
germ cell tumor243
glioma167
head and neck tumor396
kidney tumor392
leukemia582
liver tumor249
lung tumor253
lymphoma221
non-neoplasia331
ovarian tumor354
pancreatic tumor295
primitive neuroectodermal tumor of the CNS181
prostate cancer356
retinoblastoma129
skin tumor167
soft tissue/muscle tissue tumor119
uterine tumor699
Developmental Stage
TissuesTPM*
adult1
embryoid body371
blastocyst374
neonate128
fetus517
infant212
juvenile287
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue144.8
adrenal gland207.2
appendix228.6
bone marrow91.1
cerebral cortex155.6
colon134.1
duodenum166.8
esophagus143.1
gallbladder213.8
heart muscle127.1
kidney146.9
liver90.8
lung247.2
lymph node317.3
ovary316.9
pancreas86.5
placenta200.8
prostate241.4
salivary gland196.8
skin287.5
small intestine192.6
spleen310.7
stomach186.4
testis152.9
thyroid gland254.2
urinary bladder191.3
Tissues
TissuesExpression level
adrenal glandLow
appendixMedium
bone marrowMedium
breastLow
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
duodenumLow
endometrium 1Low
endometrium 2Low
epididymisMedium
esophagusMedium
fallopian tubeLow
gallbladderMedium
heart muscleLow
hippocampusMedium
kidneyLow
lateral ventricleLow
lungMedium
lymph nodeLow
nasopharynxHigh
oral mucosaLow
ovaryMedium
pancreasMedium
placentaMedium
prostateLow
rectumHigh
salivary glandLow
seminal vesicleLow
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleMedium
spleenLow
stomach 1High
stomach 2Medium
testisHigh
thyroid glandMedium
tonsilMedium
urinary bladderHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*608469, gene) Dead/h box 17; DDX17OMIM


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