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> Protein (NX_Q92843)
Protein (NX_Q92843)
Protein
Gene SymbolBCL2L2 to neXtProt (NX_Q92843)
DescriptionBcl-2-like protein 2
Chromosome14
Location14q11.2 (23767999 ~ 23780968) to Ensembl
Sequene Features : Isoforms 2, Variants 24, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of intrinsic apoptotic signaling pathway
.extrinsic apoptotic signaling pathway in absence of ligand
.Sertoli cell proliferation
  + 3 more...
.protein heterodimerization activity
.protein homodimerization activity
.extracellular exosome
.cytosol
.mitochondrial outer membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 24 2
2014-09-19protein level
2 20 2
2014-05-27protein level
2 20 13
2014-02-25protein level
2 20 7
2013-12-09protein level
2 17 7
2013-11-01protein level
2 17 6
2013-09-12protein level
2 17 6
2013-08-17protein level
2 17 6
2013-07-15protein level
2 12 3
2013-06-11protein level
2 12 3
2013-02-12protein level
2 5 1
2012-12-20protein level
2 5 1
2012-10-30protein level
2 5 1
2012-10-07protein level
2 5 1
2012-08-24protein level
2 4 1
2012-07-28protein level
2 4 1
2012-06-08protein level
2 1 1
2012-05-07protein level
2 1 1
2012-04-10protein level
2 1 1
2012-01-13protein level
2 1 1
2011-12-20protein level
2 3 1
2011-11-11protein level
1 2 1
2011-08-23protein level
1 2 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q92843-1
3 7 0 20733.2639
NX_Q92843-2
1 7 10 37147.3009
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-707714,EBI-526406 BCL2L11  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of fibroblast apoptotic process
.positive regulation of IRE1-mediated unfolded protein response
  + 42 more...
.N/A .BIM-BCL-2 complex
.BIM-BCL-xl complex
.extrinsic component of membrane
  + 3 more...
2 EBI-707714,EBI-533224 TCF4  
  .protein-DNA complex assembly
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 3 more...
.E-box binding
.protein heterodimerization activity
.bHLH transcription factor binding
  + 9 more...
.transcription factor complex
.nucleus
3 EBI-707714,EBI-519672 BID  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of extrinsic apoptotic signaling pathway
.regulation of G1/S transition of mitotic cell cycle
  + 24 more...
.death receptor binding .extracellular exosome
.integral component of mitochondrial membrane
.membrane
  + 3 more...
4 EBI-707714,EBI-516580 BAX  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.negative regulation of apoptotic signaling pathway
  + 87 more...
.BH3 domain binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.BAX complex
.Bcl-2 family protein complex
.extracellular exosome
  + 10 more...
5 EBI-707714,EBI-700794 BIK  
  .positive regulation of release of cytochrome c from mitochondria
.positive regulation of protein homooligomerization
.apoptotic mitochondrial changes
  + 3 more...
.N/A .mitochondrial membrane
.integral component of membrane
.endomembrane system
6 EBI-707714,EBI-77642 TP53BP2  
  .positive regulation of execution phase of apoptosis
.intrinsic apoptotic signaling pathway by p53 class mediator
.negative regulation of cell cycle
  + 7 more...
.NF-kappaB binding
.identical protein binding
.SH3/SH2 adaptor activity
.p53 binding
.perinuclear region of cytoplasm
.cytoplasm
.nucleus
7 EBI-707714,EBI-519866 BAK1  
  .positive regulation of IRE1-mediated unfolded protein response
.apoptotic process involved in patterning of blood vessels
.positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
  + 54 more...
.protein heterodimerization activity
.metal ion binding
.protein homodimerization activity
.identical protein binding
.pore complex
.integral component of mitochondrial outer membrane
.cytosol
  + 3 more...
8 EBI-707714,EBI-749265 CCDC155  
  .chromosome localization to nuclear envelope involved in homologous chromosome segregation
.oogenesis
.spermatogenesis
  + 2 more...
.N/A .integral component of membrane
.nuclear outer membrane
.lateral element
.chromosome, telomeric region
9 EBI-707714,EBI-743099 FATE1  
  .N/A .N/A .integral component of membrane
.endoplasmic reticulum
10 EBI-707714,EBI-3919268 BMF  
  .positive regulation of intrinsic apoptotic signaling pathway
.negative regulation of apoptotic signaling pathway
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
  + 6 more...
.N/A .myosin complex
.plasma membrane
.cytosol
  + 2 more...
11 EBI-707714,EBI-519884 BBC3  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of cysteine-type endopeptidase activity
.positive regulation of IRE1-mediated unfolded protein response
  + 21 more...
.N/A .cytosol
.mitochondrial outer membrane
.mitochondrion
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland60
blood8
bone111
brain20
cervix41
connective tissue13
embryonic tissue46
esophagus49
eye95
heart22
intestine60
kidney37
liver14
lung47
lymph node22
mammary gland13
mouth15
muscle9
ovary9
placenta7
skin4
testis2
trachea77
uterus12
Health State
TissuesTPM*
normal15
cervical tumor57
chondrosarcoma48
colorectal tumor62
esophageal tumor57
gastrointestinal tumor33
germ cell tumor11
glioma37
head and neck tumor14
kidney tumor29
liver tumor20
lung tumor9
skin tumor7
soft tissue/muscle tissue tumor7
Developmental Stage
TissuesTPM*
adult51
embryoid body71
blastocyst32
fetus35
infant127
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue39.3
adrenal gland30.3
appendix21.4
bone marrow7.6
cerebral cortex45.7
colon26.1
duodenum22.8
esophagus43.5
gallbladder23.6
heart muscle27.3
kidney31.2
liver5.5
lung28.1
lymph node9.2
ovary21
pancreas19.2
placenta20.4
prostate43.5
salivary gland45.4
skin30.6
small intestine24.7
spleen15.7
stomach24.8
testis25
thyroid gland34.5
urinary bladder25.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601931, gene) Bcl2-like 2; BCL2L2OMIM


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