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> Protein (NX_Q92844)
Protein (NX_Q92844)
Protein
Gene SymbolTANK to neXtProt (NX_Q92844)
DescriptionTRAF family member-associated NF-kappa-B activator
Chromosome2
Location2q24.2 (161993419 ~ 162092732) to Ensembl
Sequene Features : Isoforms 3, Variants 42, PTMs 12 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.innate immune response
.TRIF-dependent toll-like receptor signaling pathway
.toll-like receptor 4 signaling pathway
  + 5 more...
.metal ion binding
.ubiquitin protein ligase binding
.cytosol
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 42 12
2014-09-19protein level
3 36 12
2014-05-27protein level
3 36 12
2014-02-25protein level
3 36 12
2013-12-09protein level
3 27 12
2013-11-01protein level
3 26 10
2013-09-12protein level
3 26 9
2013-08-17protein level
3 26 9
2013-07-15protein level
3 22 9
2013-06-11protein level
3 22 9
2013-02-12protein level
3 14 19
2012-12-20protein level
3 14 19
2012-10-30protein level
3 17 19
2012-10-07protein level
3 17 17
2012-08-24protein level
3 17 17
2012-07-28protein level
3 17 17
2012-06-08protein level
3 29 17
2012-05-07protein level
3 24 17
2012-04-10protein level
2 24 17
2012-01-13protein level
2 22 17
2011-12-20protein level
2 22 17
2011-11-11protein level
2 22 17
2011-08-23protein level
2 22 16
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q92844-1
13 4 0 47785.7609
NX_Q92844-2
1 4 0 13417.7608
NX_Q92844-3
1 4 0 13617.8763
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-356349,EBI-6115839 APBA3  
  .negative regulation of catalytic activity
.protein transport
.regulation of gene expression
  + 2 more...
.enzyme binding
.enzyme inhibitor activity
.beta-amyloid binding
.perinuclear region of cytoplasm
2 EBI-356349,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
3 EBI-356349,EBI-476768 PLK1  
  .regulation of mitotic spindle assembly
.protein localization to chromatin
.regulation of cell cycle
  + 36 more...
.protein kinase binding
.kinase activity
.anaphase-promoting complex binding
  + 4 more...
.spindle midzone
.midbody
.microtubule cytoskeleton
  + 10 more...
4 EBI-356349,EBI-473220 SUMO2  
  .positive regulation of transcription from RNA polymerase II promoter
.cellular protein metabolic process
.post-translational protein modification
  + 2 more...
.poly(A) RNA binding
.ubiquitin protein ligase binding
.SUMO transferase activity
.PML body
.nucleoplasm
.nucleus
5 EBI-356349,EBI-80140 SUMO1  
  .protein localization to nuclear pore
.regulation of interferon-gamma-mediated signaling pathway
.interferon-gamma-mediated signaling pathway
  + 13 more...
.poly(A) RNA binding
.ubiquitin protein ligase binding
.SUMO transferase activity
.transcription factor binding
.synapse
.nuclear membrane
.dendrite
  + 8 more...
6 EBI-356349,EBI-1051785 SRSF11  
  .mRNA 3'-end processing
.gene expression
.RNA splicing
  + 5 more...
.poly(A) RNA binding
.nucleotide binding
.nucleoplasm
.nucleus
7 EBI-356349,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
8 EBI-356349,EBI-357631 TRAF3  
  .regulation of defense response to virus
.innate immune response
.regulation of apoptotic process
  + 14 more...
.thioesterase binding
.ubiquitin protein ligase binding
.ligase activity
  + 4 more...
.CD40 receptor complex
.cytoplasmic side of plasma membrane
.cytosol
  + 2 more...
9 EBI-356349,EBI-10175039 TP53BP2  
  .positive regulation of execution phase of apoptosis
.intrinsic apoptotic signaling pathway by p53 class mediator
.negative regulation of cell cycle
  + 7 more...
.NF-kappaB binding
.identical protein binding
.SH3/SH2 adaptor activity
.p53 binding
.perinuclear region of cytoplasm
.cytoplasm
.nucleus
10 EBI-356349,EBI-307369 IKBKE  
  .innate immune response
.positive regulation of I-kappaB kinase/NF-kappaB signaling
.NIK/NF-kappaB signaling
  + 9 more...
.IkappaB kinase activity
.ATP binding
.NF-kappaB-inducing kinase activity
.mitochondrial membrane
.PML body
.endosome membrane
  + 4 more...
11 EBI-356349,EBI-741977 CEP63  
  .cell division
.spindle assembly
.signal transduction in response to DNA damage
  + 6 more...
.N/A .cytosol
.centriole
.centrosome
.spindle pole
12 EBI-356349,EBI-356402 TBK1  
  .defense response to virus
.defense response to Gram-positive bacterium
.positive regulation of transcription from RNA polymerase II promoter
  + 20 more...
.phosphoprotein binding
.ATP binding
.protein serine/threonine kinase activity
  + 2 more...
.endosome membrane
.cytosol
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
ascites50
bladder133
blood220
bone marrow41
brain32
cervix20
connective tissue60
embryonic tissue14
esophagus49
eye28
heart33
intestine4
kidney47
liver53
lung2
lymph node55
mammary gland6
muscle37
ovary9
pancreas18
pharynx98
pituitary gland181
placenta63
prostate5
skin71
spleen56
testis22
thymus50
thyroid64
trachea38
uterus64
vascular58
Health State
TissuesTPM*
normal46
bladder carcinoma56
cervical tumor28
chondrosarcoma12
esophageal tumor57
gastrointestinal tumor16
germ cell tumor41
glioma18
head and neck tumor14
kidney tumor58
leukemia42
liver tumor52
non-neoplasia51
pancreatic tumor28
primitive neuroectodermal tumor of the CNS23
prostate cancer9
skin tumor7
soft tissue/muscle tissue tumor39
uterine tumor55
Developmental Stage
TissuesTPM*
adult33
embryoid body28
blastocyst16
neonate514
fetus32
infant85
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue35.5
adrenal gland39.1
appendix48.3
bone marrow48.9
cerebral cortex18.5
colon34.3
duodenum26.1
esophagus30.1
gallbladder47.9
heart muscle21.2
kidney25
liver33.9
lung36.2
lymph node53.1
ovary26.8
pancreas11.2
placenta38.3
prostate25.3
salivary gland21.3
skin22
small intestine28.2
spleen34.2
stomach29.9
testis23.1
thyroid gland37
urinary bladder49.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603893, gene) Traf family member-associated nf-kappa-b activator; TANKOMIM


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