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> Protein (NX_Q92851)
Protein (NX_Q92851)
Protein
Gene SymbolCASP10 to neXtProt (NX_Q92851)
DescriptionCaspase-10
Chromosome2
Location2q33.1 (202047604 ~ 202094129) to Ensembl
Sequene Features : Isoforms 7, Variants 76, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.apoptotic signaling pathway
.innate immune response
.positive regulation of I-kappaB kinase/NF-kappaB signaling
  + 3 more...
.cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.death effector domain binding
.ubiquitin protein ligase binding
.cysteine-type endopeptidase activity
.ripoptosome
.CD95 death-inducing signaling complex
.cytosol
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
7 76 2
2014-09-19protein level
7 60 2
2014-05-27protein level
7 60 2
2014-02-25protein level
7 61 2
2013-12-09protein level
7 51 2
2013-11-01protein level
7 48 2
2013-09-12protein level
6 48 2
2013-08-17protein level
6 48 2
2013-07-15protein level
6 37 0
2013-06-11protein level
6 37 0
2013-02-12protein level
6 24 6
2012-12-20protein level
6 24 6
2012-10-30protein level
6 25 6
2012-10-07protein level
6 25 1
2012-08-24protein level
6 25 1
2012-07-28protein level
6 25 1
2012-06-08protein level
6 28 1
2012-05-07protein level
6 25 1
2012-04-10protein level
6 25 1
2012-01-13protein level
6 22 1
2011-12-20protein level
6 22 1
2011-11-11protein level
6 22 1
2011-08-23protein level
6 22 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q92851-1
0 23 0 58913.0573
NX_Q92851-2
0 22 0 54531.0641
NX_Q92851-3
1 11 0 31398.9366
NX_Q92851-4
0 25 0 58956.1377
NX_Q92851-5
0 20 0 54487.9837
NX_Q92851-6
1 20 0 51751.5653
NX_Q92851-7
1 10 0 28345.6049
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-495095,EBI-1047061 RIOK3  
  .chromosome segregation .ATP binding
.protein serine/threonine kinase activity
.N/A
2 EBI-495095,EBI-514941 CFLAR  
  .negative regulation of extrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
  + 20 more...
.cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.death effector domain binding
.enzyme activator activity
.protease binding
.ripoptosome
.membrane raft
.CD95 death-inducing signaling complex
  + 3 more...
3 EBI-495095,EBI-517127 XIAP  
  .inhibition of cysteine-type endopeptidase activity involved in apoptotic process
.positive regulation of protein linear polyubiquitination
.intrinsic apoptotic signaling pathway
  + 15 more...
.ubiquitin protein ligase activity
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.ligase activity
  + 2 more...
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
4 EBI-495095,EBI-358507 RIPK1  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of extrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway
  + 48 more...
.death domain binding
.identical protein binding
.protein complex binding
  + 5 more...
.ripoptosome
.membrane raft
.receptor complex
  + 4 more...
5 EBI-495095,EBI-78060 CASP8  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
  + 55 more...
.cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.cysteine-type endopeptidase activity involved in apoptotic process
.scaffold protein binding
  + 5 more...
.ripoptosome
.membrane raft
.cell body
  + 11 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood16
bone13
bone marrow102
connective tissue26
embryonic tissue4
heart11
intestine21
kidney18
liver4
lung14
lymph node33
mammary gland6
mouth30
muscle28
nerve64
ovary9
pancreas4
pharynx24
placenta24
prostate10
skin9
spleen37
stomach41
thymus50
thyroid42
uterus17
vascular19
Health State
TissuesTPM*
normal15
breast (mammary gland) tumor10
chondrosarcoma24
colorectal tumor8
gastrointestinal tumor25
germ cell tumor26
head and neck tumor22
leukemia10
lung tumor29
lymphoma13
non-neoplasia31
pancreatic tumor9
skin tumor7
uterine tumor22
Developmental Stage
TissuesTPM*
adult16
blastocyst16
neonate32
fetus23
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue6.3
adrenal gland2.3
appendix11
bone marrow13.2
cerebral cortex1.5
colon14.5
duodenum22.2
esophagus8.3
gallbladder8.9
heart muscle3.3
kidney5
liver3.5
lung11.7
lymph node9.6
ovary1.1
pancreas1.9
placenta8.4
prostate2.2
salivary gland2.6
skin4.5
small intestine20
spleen18.3
stomach11.3
testis1.5
thyroid gland5.5
urinary bladder13.9
Tissues
TissuesExpression level
adrenal glandMedium
appendixLow
bone marrowMedium
breastLow
bronchusLow
cerebellumLow
cerebral cortexLow
cervix, uterineLow
colonMedium
duodenumMedium
endometrium 1Low
endometrium 2Low
epididymisLow
fallopian tubeLow
gallbladderLow
heart muscleLow
hippocampusLow
kidneyLow
lateral ventricleLow
lungMedium
lymph nodeMedium
nasopharynxLow
ovaryLow
pancreasLow
parathyroid glandMedium
placentaLow
prostateLow
rectumMedium
seminal vesicleMedium
skin 1Low
skin 2Low
small intestineMedium
smooth muscleLow
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandLow
tonsilMedium
urinary bladderMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601762, gene) Caspase 10, apoptosis-related cysteine protease; CASP10OMIM
2(#603909, phenotype) Autoimmune lymphoproliferative syndrome, type iia; ALPS2AOMIM
3(#605027, phenotype) Lymphoma, non-hodgkin, familialOMIM
4(#613659, phenotype) Gastric cancerOMIM


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