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> Protein (NX_Q92882)
Protein (NX_Q92882)
Protein
Gene SymbolOSTF1 to neXtProt (NX_Q92882)
DescriptionOsteoclast-stimulating factor 1
Chromosome9
Location9q21.13 (77703459 ~ 77762181) to Ensembl
Sequene Features : Isoforms 1, Variants 19, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.signal transduction
.ossification
.N/A .extracellular exosome
.cytoplasm
.intracellular
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 19 6
2014-09-19protein level
1 17 6
2014-05-27protein level
1 17 6
2014-02-25protein level
1 17 6
2013-12-09protein level
1 14 6
2013-11-01protein level
1 11 6
2013-09-12protein level
1 11 5
2013-08-17protein level
1 11 5
2013-07-15protein level
1 8 3
2013-06-11protein level
1 8 3
2013-02-12protein level
1 6 3
2012-12-20protein level
1 6 3
2012-10-30protein level
1 5 3
2012-10-07protein level
1 5 3
2012-08-24protein level
1 5 3
2012-07-28protein level
1 5 3
2012-06-08protein level
1 7 3
2012-05-07protein level
1 7 3
2012-04-10protein level
1 7 3
2012-01-13protein level
1 6 3
2011-12-20protein level
1 6 3
2011-11-11protein level
1 6 3
2011-08-23protein level
1 6 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q92882-1
11 0 0 23771.8665
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1051152,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
2 EBI-1051152,EBI-718488 EFS  
  .intracellular signal transduction
.cell adhesion
.protein domain specific binding .cytoplasm
3 EBI-1051152,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
4 EBI-1051152,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
5 EBI-1051152,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood49
bone marrow20
brain21
connective tissue6
embryonic tissue9
eye28
heart22
intestine60
kidney14
larynx42
lung11
lymph node66
mammary gland39
muscle18
nerve64
pancreas9
placenta21
prostate5
skin14
stomach10
testis9
thyroid21
tonsil117
uterus64
vascular19
Health State
TissuesTPM*
normal17
breast (mammary gland) tumor53
colorectal tumor115
gastrointestinal tumor8
germ cell tumor11
glioma74
head and neck tumor14
kidney tumor14
leukemia31
lung tumor29
lymphoma27
non-neoplasia10
primitive neuroectodermal tumor of the CNS7
prostate cancer9
skin tumor15
soft tissue/muscle tissue tumor15
uterine tumor133
Developmental Stage
TissuesTPM*
adult33
embryoid body28
fetus7
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue37.3
adrenal gland37.5
appendix61.9
bone marrow32.1
cerebral cortex29.5
colon43.3
duodenum32.9
esophagus85.6
gallbladder45
heart muscle24.1
kidney29.6
liver30.5
lung54.4
lymph node69.1
ovary13.6
pancreas8.7
placenta65.5
prostate24.5
salivary gland27.9
skin50.6
small intestine42.3
spleen73.6
stomach39.1
testis20.8
thyroid gland31.2
urinary bladder59.3
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexMedium
cervix, uterineMedium
colonHigh
duodenumHigh
epididymisLow
esophagusMedium
fallopian tubeLow
gallbladderMedium
heart muscleLow
hippocampusMedium
kidneyLow
lateral ventricleMedium
liverLow
lungMedium
lymph nodeHigh
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateLow
rectumHigh
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2Low
small intestineHigh
soft tissue 1High
soft tissue 2High
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*610180, gene) Osteoclast-stimulating factor 1; OSTF1OMIM


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