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> Protein (NX_Q92889)
Protein (NX_Q92889)
Protein
Gene SymbolERCC4 to neXtProt (NX_Q92889)
DescriptionDNA repair endonuclease XPF
Chromosome16
Location16p13.12 (14014014 ~ 14046202) to Ensembl
Sequene Features : Isoforms 2, Variants 160, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.nucleotide-excision repair involved in interstrand cross-link repair
.nucleotide-excision repair, DNA incision
.negative regulation of telomere maintenance
  + 11 more...
.protein N-terminus binding
.protein C-terminus binding
.endodeoxyribonuclease activity
  + 3 more...
.transcription factor TFIID complex
.nucleoplasm
.nucleus
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 160 2
2014-09-19protein level
1 134 2
2014-05-27protein level
1 133 2
2014-02-25protein level
1 133 2
2013-12-09protein level
1 111 2
2013-11-01protein level
1 110 1
2013-09-12protein level
1 107 1
2013-08-17protein level
1 107 1
2013-07-15protein level
1 78 1
2013-06-11protein level
1 78 1
2013-02-12protein level
1 52 4
2012-12-20protein level
1 52 4
2012-10-30protein level
1 63 4
2012-10-07protein level
1 63 4
2012-08-24protein level
1 61 4
2012-07-28protein level
1 60 4
2012-06-08protein level
1 60 4
2012-05-07protein level
1 54 4
2012-04-10protein level
1 54 4
2012-01-13protein level
1 37 4
2011-12-20protein level
1 37 4
2011-11-11protein level
1 37 4
2011-08-23protein level
1 37 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q92889-1
28 17 0 104419.9937
NX_Q92889-2
1 17 0 42717.2807
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2370770,EBI-750962 ERCC1  
  .chromosome organization
.embryonic organ development
.oogenesis
  + 26 more...
.protein domain specific binding
.protein C-terminus binding
.endonuclease activity
  + 2 more...
.cytoplasm
.transcription factor TFIID complex
.nucleoplasm
  + 3 more...
2 EBI-2370770,EBI-2370740 SLX4  
  .response to intra-S DNA damage checkpoint signaling
.positive regulation of catalytic activity
.DNA double-strand break processing involved in repair via single-strand annealing
  + 4 more...
.5'-flap endonuclease activity
.enzyme activator activity
.Slx1-Slx4 complex
.cell junction
.cytoplasm
.nucleoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bone41
bone marrow20
brain11
embryonic tissue18
eye9
kidney9
liver9
lung17
lymph node33
mammary gland59
mouth15
muscle18
ovary19
placenta14
prostate5
spleen37
testis48
thymus12
uterus4
Health State
TissuesTPM*
normal15
breast (mammary gland) tumor21
head and neck tumor7
leukemia10
liver tumor10
lung tumor9
ovarian tumor13
primitive neuroectodermal tumor of the CNS23
prostate cancer9
uterine tumor11
Developmental Stage
TissuesTPM*
adult9
embryoid body42
blastocyst16
fetus14
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue3
adrenal gland4.2
appendix3.3
bone marrow1.1
cerebral cortex4.2
colon2.3
duodenum1.6
esophagus3
gallbladder3.1
heart muscle2.7
kidney3.6
liver1.7
lung3.1
lymph node3.6
ovary4
pancreas2.8
placenta2.3
prostate4
salivary gland2.3
skin2.3
small intestine1.8
spleen3.5
stomach2.9
testis10.7
thyroid gland4.4
urinary bladder4
Tissues
TissuesExpression level
adrenal glandMedium
appendixLow
breastMedium
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineMedium
colonLow
endometrium 1Medium
endometrium 2Low
epididymisHigh
fallopian tubeMedium
gallbladderHigh
heart muscleMedium
hippocampusMedium
kidneyMedium
lateral ventricleLow
liverMedium
lungLow
lymph nodeMedium
oral mucosaLow
pancreasMedium
parathyroid glandMedium
placentaHigh
prostateMedium
rectumLow
salivary glandLow
seminal vesicleMedium
skin 1Medium
skin 2Medium
soft tissue 1Medium
soft tissue 2Medium
spleenLow
stomach 1Low
stomach 2Low
testisMedium
thyroid glandMedium
tonsilLow
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*133520, gene) Excision-repair, complementing defective, in chinese hamster, 4; ERCC4OMIM
2(#278760, phenotype) Xeroderma pigmentosum, complementation group f; XPFOMIM
3(#610965, phenotype) Xfe progeroid syndromeOMIM
4skin basal cell;skin squamous cell;melanoma;Xeroderma pigmentosum (F)CGP


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