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> Protein (NX_Q92905)
Protein (NX_Q92905)
Protein
Gene SymbolCOPS5 to neXtProt (NX_Q92905)
DescriptionCOP9 signalosome complex subunit 5
Chromosome8
Location8q13.1 (67955314 ~ 67996018) to Ensembl
Sequene Features : Isoforms 1, Variants 38, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.exosomal secretion
.regulation of IRE1-mediated unfolded protein response
.regulation of cell cycle
  + 8 more...
.metal ion binding
.metallopeptidase activity
.ubiquitin-specific protease activity
  + 2 more...
.perinuclear region of cytoplasm
.cell junction
.COP9 signalosome
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 38 8
2014-09-19protein level
1 32 8
2014-05-27protein level
1 32 8
2014-02-25protein level
1 31 8
2013-12-09protein level
1 23 8
2013-11-01protein level
1 19 5
2013-09-12protein level
1 19 5
2013-08-17protein level
1 19 5
2013-07-15protein level
1 12 2
2013-06-11protein level
1 12 2
2013-02-12protein level
1 3 3
2012-12-20protein level
1 3 3
2012-10-30protein level
1 3 3
2012-10-07protein level
1 3 3
2012-08-24protein level
1 2 3
2012-07-28protein level
1 2 3
2012-06-08protein level
1 5 3
2012-05-07protein level
1 5 3
2012-04-10protein level
1 5 3
2012-01-13protein level
1 9 3
2011-12-20protein level
1 9 3
2011-11-11protein level
1 9 3
2011-08-23protein level
1 9 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q92905-1
17 0 0 37554.6135
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-594661,EBI-3861591 SMAD7  
  .cellular response to transforming growth factor beta stimulus
.ventricular septum morphogenesis
.negative regulation of pathway-restricted SMAD protein phosphorylation
  + 32 more...
.I-SMAD binding
.activin binding
.metal ion binding
  + 6 more...
.protein complex
.plasma membrane
.cytosol
  + 4 more...
2 EBI-594661,EBI-748961 CCNDBP1  
  .regulation of cell cycle
.cell cycle
.N/A .cytoplasm
.nucleoplasm
.nucleus
3 EBI-594661,EBI-714860 UCHL1  
  .neuromuscular process
.muscle fiber development
.negative regulation of MAP kinase activity
  + 9 more...
.ubiquitin binding
.alpha-2A adrenergic receptor binding
.ubiquitin protein ligase binding
  + 4 more...
.extracellular exosome
.neuronal cell body
.axon
  + 4 more...
4 EBI-594661,EBI-594644 TXN  
  .negative regulation of hydrogen peroxide-induced cell death
.oxidation-reduction process
.nucleobase-containing small molecule metabolic process
  + 23 more...
.poly(A) RNA binding
.oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
.peptide disulfide oxidoreductase activity
.protein disulfide oxidoreductase activity
.extracellular exosome
.cytosol
.mitochondrion
  + 3 more...
5 EBI-594661,EBI-2624570 OPRM1  
  .regulation of N-methyl-D-aspartate selective glutamate receptor activity
.cellular response to morphine
.response to growth factor
  + 30 more...
.neuropeptide binding
.morphine receptor activity
.G-protein beta-subunit binding
  + 4 more...
.membrane raft
.perikaryon
.neuron projection
  + 8 more...
6 EBI-594661,EBI-519280 CDKN1B  
  .mitotic cell cycle arrest
.cellular response to organic cyclic compound
.cellular response to lithium ion
  + 39 more...
.protein phosphatase binding
.transforming growth factor beta receptor, cytoplasmic mediator activity
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.Cul4A-RING E3 ubiquitin ligase complex
.cytosol
.endosome
  + 3 more...
7 EBI-594661,EBI-4303189 F2RL1  
  .positive regulation of interleukin-6 secretion
.positive regulation of interleukin-8 secretion
.positive regulation of renin secretion into blood stream
  + 46 more...
.G-protein beta-subunit binding
.thrombin receptor activity
.receptor binding
  + 3 more...
.pseudopodium
.integral component of plasma membrane
.plasma membrane
  + 2 more...
8 EBI-594661,EBI-725197 GPS1  
  .negative regulation of GTPase activity
.cullin deneddylation
.JNK cascade
  + 2 more...
.GTPase inhibitor activity .COP9 signalosome
.cytoplasm
.nucleus
9 EBI-594661,EBI-2372238 RNF20  
  .positive regulation of histone H2B ubiquitination
.negative regulation of mRNA polyadenylation
.positive regulation of transcription, DNA-templated
  + 7 more...
.histone binding
.ubiquitin protein ligase binding
.ligase activity
  + 6 more...
.HULC complex
.nucleolus
.nucleoplasm
  + 2 more...
10 EBI-594661,EBI-724928 FAM188A  
  .apoptotic process .N/A .nuclear membrane
.nucleoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland60
ascites50
blood49
bone167
bone marrow123
brain89
connective tissue26
ear62
embryonic tissue122
eye105
heart100
intestine94
kidney99
larynx127
liver34
lung167
lymph90
lymph node200
mammary gland72
mouth60
muscle357
nerve64
ovary147
pancreas154
parathyroid48
pharynx73
placenta81
prostate137
salivary gland49
skin166
spleen74
stomach62
testis114
thymus87
thyroid150
tonsil411
trachea38
umbilical cord145
uterus129
vascular77
Health State
TissuesTPM*
normal77
adrenal tumor79
breast (mammary gland) tumor96
chondrosarcoma181
colorectal tumor151
gastrointestinal tumor151
germ cell tumor83
glioma130
head and neck tumor104
kidney tumor116
leukemia84
liver tumor62
lung tumor243
lymphoma138
non-neoplasia41
ovarian tumor144
pancreatic tumor190
primitive neuroectodermal tumor of the CNS133
prostate cancer154
retinoblastoma107
skin tumor239
soft tissue/muscle tissue tumor303
uterine tumor122
Developmental Stage
TissuesTPM*
adult63
embryoid body85
blastocyst130
neonate64
fetus55
infant170
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue36.5
adrenal gland41.9
appendix35.6
bone marrow31.8
cerebral cortex39.8
colon44.6
duodenum42.5
esophagus41.2
gallbladder36
heart muscle70.7
kidney41.7
liver30.5
lung33.5
lymph node44.1
ovary37.2
pancreas19.6
placenta46
prostate37.3
salivary gland29.5
skin34
small intestine45.1
spleen35
stomach34.4
testis78.5
thyroid gland38
urinary bladder40.7
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleHigh
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverHigh
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryHigh
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleHigh
skin 1High
skin 2High
small intestineHigh
smooth muscleHigh
soft tissue 1High
soft tissue 2High
spleenMedium
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604850, gene) Cop9, subunit 5; COPS5OMIM


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