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> Protein (NX_Q92917)
Protein (NX_Q92917)
Protein
Gene SymbolGPKOW to neXtProt (NX_Q92917)
DescriptionG patch domain and KOW motifs-containing protein
ChromosomeX
LocationXp11.23 (48970334 ~ 48980151) to Ensembl
Sequene Features : Isoforms 1, Variants 57, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .nucleic acid binding .nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 57 7
2014-09-19protein level
1 43 7
2014-05-27protein level
1 43 7
2014-02-25protein level
1 43 7
2013-12-09protein level
1 39 7
2013-11-01protein level
1 39 4
2013-09-12protein level
1 39 3
2013-08-17protein level
1 39 3
2013-07-15protein level
1 26 2
2013-06-11protein level
1 26 2
2013-02-12protein level
1 14 3
2012-12-20protein level
1 11 3
2012-10-30protein level
1 15 3
2012-10-07protein level
1 15 3
2012-08-24protein level
1 14 3
2012-07-28protein level
1 14 3
2012-06-08protein level
1 15 3
2012-05-07protein level
1 15 3
2012-04-10protein level
1 15 3
2012-01-13protein level
1 2 3
2011-12-20protein level
1 2 3
2011-11-11protein level
1 2 3
2011-08-23protein level
1 2 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q92917-1
22 0 0 52196.4126
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-746309,EBI-718395 PRPF4  
  .gene expression
.RNA splicing
.RNA processing
  + 2 more...
.U4 snRNA binding
.U6 snRNA binding
.U4/U6 snRNP
.U4/U6 x U5 tri-snRNP complex
.nuclear speck
  + 4 more...
2 EBI-746309,EBI-311446 DHX16  
  .RNA splicing
.mRNA splicing, via spliceosome
.poly(A) RNA binding
.ATP binding
.ATP-dependent RNA helicase activity
.RNA helicase activity
.cytoplasm
.spliceosomal complex
.nucleoplasm
.nucleus
3 EBI-746309,EBI-5258763 PRKACB  
  .negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
.response to clozapine
.cellular response to glucagon stimulus
  + 26 more...
.ubiquitin protein ligase binding
.ATP binding
.cAMP-dependent protein kinase activity
.magnesium ion binding
.ciliary base
.extracellular exosome
.perinuclear region of cytoplasm
  + 5 more...
4 EBI-746309,EBI-740098 TRIM23  
  .positive regulation of catalytic activity
.protein ubiquitination
.viral process
.small GTPase mediated signal transduction
.identical protein binding
.GDP binding
.ligase activity
  + 5 more...
.extracellular exosome
.lysosomal membrane
.nucleus
.Golgi membrane
5 EBI-746309,EBI-4302903 PRKX  
  .regulation of epithelial cell differentiation involved in kidney development
.kidney morphogenesis
.epithelial tube morphogenesis
  + 10 more...
.ATP binding
.cAMP-dependent protein kinase activity
.cytoplasm
.nucleus
6 EBI-746309,EBI-721525 RBM10  
  .RNA splicing
.mRNA processing
.poly(A) RNA binding
.identical protein binding
.protein complex binding
  + 2 more...
.nucleoplasm
.nucleus
7 EBI-746309,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
8 EBI-746309,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
9 EBI-746309,EBI-710310 TCEA2  
  .positive regulation of transcription from RNA polymerase II promoter
.regulation of DNA-templated transcription, elongation
.DNA-templated transcription, elongation
.zinc ion binding
.DNA binding
.transcription elongation factor complex
.centrosome
.nucleoplasm
10 EBI-746309,EBI-2808286 CCDC57  
  .N/A .N/A .N/A
11 EBI-746309,EBI-538479 PRPF8  
  .gene expression
.RNA splicing
.mRNA processing
  + 3 more...
.pre-mRNA intronic binding
.K63-linked polyubiquitin binding
.poly(A) RNA binding
  + 5 more...
.catalytic step 2 spliceosome
.nuclear speck
.membrane
  + 3 more...
12 EBI-746309,EBI-1043041 DHX38  
  .mRNA 3'-end processing
.gene expression
.RNA splicing
  + 4 more...
.poly(A) RNA binding
.ATP binding
.ATP-dependent RNA helicase activity
.catalytic step 2 spliceosome
.membrane
.cytoplasm
  + 2 more...
13 EBI-746309,EBI-2561235 BUD13  
  .mRNA export from nucleus
.mRNA splicing, via spliceosome
.poly(A) RNA binding .RES complex
.nucleoplasm
.nucleus
14 EBI-746309,EBI-1378139 ROPN1  
  .small GTPase mediated signal transduction .N/A .cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
ascites175
blood130
bone69
brain25
cervix185
connective tissue33
embryonic tissue75
eye38
intestine51
kidney23
larynx42
liver43
lung71
lymph22
lymph node22
mammary gland46
mouth90
nerve128
ovary39
pancreas60
pituitary gland121
placenta77
prostate26
salivary gland49
skin47
spleen56
stomach10
testis4
thyroid21
tonsil58
uterus25
Health State
TissuesTPM*
normal36
adrenal tumor79
breast (mammary gland) tumor75
cervical tumor28
chondrosarcoma60
colorectal tumor62
gastrointestinal tumor101
germ cell tumor53
glioma27
head and neck tumor67
kidney tumor43
leukemia84
liver tumor20
lung tumor145
lymphoma13
non-neoplasia20
ovarian tumor26
pancreatic tumor38
primitive neuroectodermal tumor of the CNS118
prostate cancer28
retinoblastoma43
skin tumor55
soft tissue/muscle tissue tumor31
uterine tumor11
Developmental Stage
TissuesTPM*
adult52
embryoid body42
blastocyst146
fetus30
infant127
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue11.8
adrenal gland11
appendix10.1
bone marrow8.5
cerebral cortex15.7
colon12.7
duodenum11.1
esophagus11.9
gallbladder10.3
heart muscle12.1
kidney11.3
liver8.2
lung11.4
lymph node13.3
ovary11
pancreas4.8
placenta12
prostate11.6
salivary gland8.6
skin11.4
small intestine10.6
spleen12.1
stomach11.6
testis7.6
thyroid gland11.7
urinary bladder11.7
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastHigh
bronchusMedium
cerebellumHigh
cerebral cortexMedium
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1High
endometrium 2Medium
epididymisHigh
esophagusMedium
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusMedium
kidneyHigh
lateral ventricleMedium
liverMedium
lungHigh
lymph nodeMedium
nasopharynxMedium
oral mucosaHigh
ovaryMedium
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandMedium
seminal vesicleHigh
skeletal muscleMedium
skin 1High
skin 2High
small intestineHigh
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1High
stomach 2High
testisHigh
thyroid glandMedium
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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