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> Protein (NX_Q92918)
Protein (NX_Q92918)
Protein
Gene SymbolMAP4K1 to neXtProt (NX_Q92918)
DescriptionMitogen-activated protein kinase kinase kinase kinase 1
Chromosome19
Location19q13.2 (39078281 ~ 39109522) to Ensembl
Sequene Features : Isoforms 2, Variants 87, PTMs 10 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein autophosphorylation
.regulation of apoptotic process
.intracellular signal transduction
  + 7 more...
.MAP kinase kinase kinase kinase activity
.ATP binding
.protein serine/threonine kinase activity
.protein kinase activity
.membrane
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 87 10
2014-09-19protein level
2 71 10
2014-05-27protein level
2 71 6
2014-02-25protein level
2 70 6
2013-12-09protein level
2 60 6
2013-11-01protein level
2 57 6
2013-09-12protein level
2 57 6
2013-08-17protein level
2 57 6
2013-07-15protein level
2 38 5
2013-06-11protein level
2 38 5
2013-02-12protein level
2 16 24
2012-12-20protein level
2 15 24
2012-10-30protein level
2 19 24
2012-10-07protein level
2 19 12
2012-08-24protein level
2 15 12
2012-07-28protein level
2 15 12
2012-06-08protein level
2 16 12
2012-05-07protein level
2 11 12
2012-04-10protein level
2 11 12
2012-01-13protein level
2 9 12
2011-12-20protein level
2 9 12
2011-11-11protein level
2 9 12
2011-08-23protein level
2 9 12
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q92918-1
1 37 0 91237.9494
NX_Q92918-2
1 37 0 90367.5357
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-881,EBI-375543 ABL1  
  .regulation of response to DNA damage stimulus
.negative regulation of cellular senescence
.negative regulation of endothelial cell apoptotic process
  + 73 more...
.proline-rich region binding
.mitogen-activated protein kinase binding
.manganese ion binding
  + 12 more...
.perinuclear region of cytoplasm
.nuclear membrane
.cell leading edge
  + 8 more...
2 EBI-881,EBI-515315 FYN  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of protein localization to nucleus
.cellular response to peptide hormone stimulus
  + 47 more...
.growth factor receptor binding
.ephrin receptor binding
.metal ion binding
  + 4 more...
.extrinsic component of cytoplasmic side of plasma membrane
.postsynaptic density
.plasma membrane
  + 5 more...
3 EBI-881,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
4 EBI-881,EBI-79387 PLCG1  
  .cellular response to epidermal growth factor stimulus
.positive regulation of release of sequestered calcium ion into cytosol
.leukocyte migration
  + 24 more...
.protein kinase binding
.calcium ion binding
.neurotrophin TRKA receptor binding
  + 3 more...
.cell projection
.lamellipodium
.COP9 signalosome
  + 5 more...
5 EBI-881,EBI-79464 PIK3R1  
  .positive regulation of endoplasmic reticulum unfolded protein response
.positive regulation of establishment of protein localization to plasma membrane
.growth hormone receptor signaling pathway
  + 41 more...
.1-phosphatidylinositol-3-kinase regulator activity
.insulin receptor substrate binding
.insulin binding
  + 9 more...
.membrane
.phosphatidylinositol 3-kinase complex, class IA
.phosphatidylinositol 3-kinase complex
  + 5 more...
6 EBI-881,EBI-886 CRK  
  .ephrin receptor signaling pathway
.neurotrophin TRK receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 9 more...
.ephrin receptor binding
.SH2 domain binding
.extracellular exosome
.actin cytoskeleton
.plasma membrane
  + 3 more...
7 EBI-881,EBI-910 CRKL  
  .parathyroid gland development
.thymus development
.neurotrophin TRK receptor signaling pathway
  + 8 more...
.poly(A) RNA binding
.SH3/SH2 adaptor activity
.signal transducer activity
.extracellular exosome
.cytosol
.endosome
8 EBI-881,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood65
bone13
bone marrow41
brain4
connective tissue6
eye19
intestine4
larynx85
lung5
lymph135
lymph node167
mammary gland6
muscle37
pancreas18
placenta3
skin4
spleen56
stomach10
testis9
thymus87
tonsil411
uterus12
Health State
TissuesTPM*
normal17
breast (mammary gland) tumor10
germ cell tumor34
glioma9
head and neck tumor14
leukemia21
lymphoma235
pancreatic tumor38
skin tumor7
soft tissue/muscle tissue tumor7
uterine tumor33
Developmental Stage
TissuesTPM*
adult13
fetus10
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue4
adrenal gland3.6
appendix40.2
bone marrow15.5
cerebral cortex2.3
colon6.6
duodenum7.2
esophagus3.9
gallbladder7.2
heart muscle2.8
kidney2.4
liver2.8
lung14.2
lymph node74.4
ovary1.4
placenta3.7
prostate3.1
salivary gland5.8
skin4.2
small intestine11
spleen50.8
stomach11.5
testis2.5
thyroid gland2
urinary bladder12.9
Tissues
TissuesExpression level
appendixMedium
bone marrowHigh
lungLow
lymph nodeHigh
skeletal muscleLow
spleenMedium
tonsilHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601983, gene) Mitogen-activated protein kinase kinase kinase kinase 1; MAP4K1OMIM


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