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> Protein (NX_Q92934)
Protein (NX_Q92934)
Protein
Gene SymbolBAD to neXtProt (NX_Q92934)
DescriptionBcl2-associated agonist of cell death
Chromosome11
Location11q13.1 (64037302 ~ 64052176) to Ensembl
Sequene Features : Isoforms 1, Variants 18, PTMs 11 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of type B pancreatic cell development
.positive regulation of neuron death
  + 58 more...
.protein kinase binding
.cysteine-type endopeptidase activator activity involved in apoptotic process
.lipid binding
.phospholipid binding
.cytosol
.mitochondrial outer membrane
.mitochondrion
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 18 11
2014-09-19protein level
1 12 11
2014-05-27protein level
1 12 11
2014-02-25protein level
1 12 10
2013-12-09protein level
1 5 10
2013-11-01protein level
1 5 9
2013-09-12protein level
1 5 8
2013-08-17protein level
1 5 8
2013-07-15protein level
1 5 8
2013-06-11protein level
1 5 8
2013-02-12protein level
1 3 9
2012-12-20protein level
1 3 9
2012-10-30protein level
1 4 9
2012-10-07protein level
1 4 9
2012-08-24protein level
1 3 9
2012-07-28protein level
1 3 7
2012-06-08protein level
1 3 7
2012-05-07protein level
1 3 7
2012-04-10protein level
1 3 7
2012-01-13protein level
1 3 7
2011-12-20protein level
1 3 7
2011-11-11protein level
1 3 7
2011-08-23protein level
1 3 7
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q92934-1
8 0 0 18380.6514
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-700771,EBI-526406 BCL2L11  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of fibroblast apoptotic process
.positive regulation of IRE1-mediated unfolded protein response
  + 42 more...
.N/A .BIM-BCL-2 complex
.BIM-BCL-xl complex
.extrinsic component of membrane
  + 3 more...
2 EBI-700771,EBI-849893 BNIP3L  
  .mitochondrial outer membrane permeabilization
.defense response to virus
.negative regulation of apoptotic process
  + 3 more...
.protein heterodimerization activity
.protein homodimerization activity
.identical protein binding
.lamin binding
.intrinsic component of membrane
.integral component of membrane
.endoplasmic reticulum
  + 3 more...
3 EBI-700771,EBI-365996 RAF1  
  .regulation of cell motility
.negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
.death-inducing signaling complex assembly
  + 36 more...
.metal ion binding
.identical protein binding
.ATP binding
  + 3 more...
.pseudopodium
.plasma membrane
.cytosol
  + 4 more...
4 EBI-700771,EBI-77694 BCL2  
  .positive regulation of intrinsic apoptotic signaling pathway
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
  + 111 more...
.BH3 domain binding
.protein heterodimerization activity
.sequence-specific DNA binding
  + 6 more...
.pore complex
.myelin sheath
.nuclear membrane
  + 8 more...
5 EBI-700771,EBI-476295 SFN  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.negative regulation of protein serine/threonine kinase activity
  + 20 more...
.protein kinase C inhibitor activity .extracellular exosome
.cytoplasmic vesicle membrane
.cytosol
  + 3 more...
6 EBI-700771,EBI-286483 MAPK8  
  .positive regulation of determination of dorsal identity
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.programmed necrotic cell death
  + 45 more...
.histone deacetylase binding
.histone deacetylase regulator activity
.enzyme binding
  + 3 more...
.cytosol
.mitochondrion
.nucleoplasm
.nucleus
7 EBI-700771,EBI-347088 YWHAZ  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.Golgi reassembly
  + 14 more...
.poly(A) RNA binding
.identical protein binding
.ubiquitin protein ligase binding
  + 2 more...
.blood microparticle
.extracellular exosome
.perinuclear region of cytoplasm
  + 13 more...
8 EBI-700771,EBI-78035 BCL2L1  
  .positive regulation of intrinsic apoptotic signaling pathway
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
  + 42 more...
.BH3 domain binding
.protein heterodimerization activity
.protein homodimerization activity
  + 2 more...
.Bcl-2 family protein complex
.nuclear membrane
.synaptic vesicle membrane
  + 11 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites50
bladder66
bone41
brain28
connective tissue6
embryonic tissue23
eye129
heart44
intestine64
kidney52
liver19
lung74
lymph node100
mammary gland19
muscle9
nerve128
ovary68
pancreas51
pharynx24
placenta35
prostate105
salivary gland148
skin71
testis22
thymus37
thyroid21
uterus38
Health State
TissuesTPM*
normal40
breast (mammary gland) tumor21
chondrosarcoma60
colorectal tumor106
gastrointestinal tumor16
germ cell tumor26
glioma102
head and neck tumor37
leukemia31
liver tumor20
lung tumor68
non-neoplasia31
ovarian tumor65
pancreatic tumor76
prostate cancer77
retinoblastoma172
skin tumor71
soft tissue/muscle tissue tumor23
uterine tumor44
Developmental Stage
TissuesTPM*
adult49
embryoid body28
neonate32
fetus46
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue29.1
adrenal gland20.5
appendix12.8
bone marrow15.2
cerebral cortex26.3
colon30.8
duodenum20.5
esophagus11.9
gallbladder16.6
heart muscle26.9
kidney33.4
liver16.2
lung23.9
lymph node12.8
ovary14.9
pancreas13.6
placenta21.5
prostate35.2
salivary gland35.2
skin18.1
small intestine21.7
spleen19
stomach44.4
testis22.1
thyroid gland16.2
urinary bladder14.7
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowLow
breastMedium
bronchusHigh
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleMedium
hippocampusMedium
kidneyHigh
lateral ventricleHigh
liverMedium
lungMedium
lymph nodeLow
nasopharynxHigh
oral mucosaLow
pancreasMedium
parathyroid glandMedium
placentaHigh
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skin 1Low
skin 2Medium
small intestineMedium
soft tissue 1Medium
soft tissue 2Medium
spleenLow
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603167, gene) Bcl2 antagonist of cell death; BADOMIM


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