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> Protein (NX_Q92973)
Protein (NX_Q92973)
Protein
Gene SymbolTNPO1 to neXtProt (NX_Q92973)
DescriptionTransportin-1
Chromosome5
Location5q13.2 (72112139 ~ 72212560) to Ensembl
Sequene Features : Isoforms 3, Variants 80, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.viral process
.gene expression
.organelle organization
.protein import into nucleus, translocation
.poly(A) RNA binding
.nuclear localization sequence binding
.primary cilium
.extracellular exosome
.cytosol
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 80 4
2014-09-19protein level
3 67 4
2014-05-27protein level
3 67 8
2014-02-25protein level
3 68 8
2013-12-09protein level
3 57 8
2013-11-01protein level
3 55 4
2013-09-12protein level
3 55 4
2013-08-17protein level
3 55 4
2013-07-15protein level
3 33 3
2013-06-11protein level
3 33 3
2013-02-12protein level
3 15 9
2012-12-20protein level
3 15 9
2012-10-30protein level
3 15 9
2012-10-07protein level
3 15 4
2012-08-24protein level
3 13 4
2012-07-28protein level
3 13 4
2012-06-08protein level
3 19 4
2012-05-07protein level
3 6 4
2012-04-10protein level
3 6 4
2012-01-13protein level
3 11 4
2011-12-20protein level
3 11 4
2011-11-11protein level
3 11 4
2011-08-23protein level
3 11 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q92973-1
0 32 6 102288.4941
NX_Q92973-2
0 32 6 101243.9796
NX_Q92973-3
1 29 5 96837.7053
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-286693,EBI-286642 RAN  
  .protein localization to nucleolus
.intracellular transport of virus
.cell division
  + 21 more...
.androgen receptor binding
.poly(A) RNA binding
.GDP binding
  + 4 more...
.extracellular exosome
.recycling endosome
.RNA nuclear export complex
  + 10 more...
2 EBI-286693,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland364
ascites200
bladder100
blood65
bone111
bone marrow41
brain156
cervix206
connective tissue80
ear248
embryonic tissue183
esophagus99
eye119
heart111
intestine99
kidney213
larynx85
liver116
lung80
lymph112
lymph node200
mammary gland112
mouth272
muscle235
nerve193
ovary39
pancreas149
parathyroid291
pituitary gland181
placenta180
prostate158
salivary gland148
skin118
spleen112
stomach10
testis202
thymus313
thyroid150
trachea154
umbilical cord145
uterus137
vascular580
Health State
TissuesTPM*
normal173
adrenal tumor474
breast (mammary gland) tumor128
cervical tumor231
chondrosarcoma48
colorectal tumor53
esophageal tumor115
gastrointestinal tumor67
germ cell tumor269
glioma18
head and neck tumor179
kidney tumor130
leukemia116
liver tumor114
lung tumor29
lymphoma138
non-neoplasia72
ovarian tumor78
pancreatic tumor76
primitive neuroectodermal tumor of the CNS70
prostate cancer96
retinoblastoma107
skin tumor79
soft tissue/muscle tissue tumor95
uterine tumor88
Developmental Stage
TissuesTPM*
adult120
embryoid body171
blastocyst227
neonate289
fetus298
infant212
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue26.6
adrenal gland32.9
appendix36.1
bone marrow26
cerebral cortex23.1
colon31.7
duodenum25.6
esophagus28.4
gallbladder37.6
heart muscle24
kidney31.9
liver18.2
lung22.3
lymph node34.9
ovary32.2
pancreas17.5
placenta45.8
prostate31.8
salivary gland18.7
skin13.2
small intestine24.8
spleen26.2
stomach37.5
testis45.6
thyroid gland45.4
urinary bladder40.7
Tissues
TissuesExpression level
adrenal glandHigh
appendixMedium
bone marrowHigh
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleHigh
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverLow
lungHigh
lymph nodeMedium
nasopharynxHigh
oral mucosaHigh
ovaryMedium
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateMedium
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleMedium
skin 1High
skin 2Medium
small intestineHigh
smooth muscleMedium
soft tissue 1High
soft tissue 2Medium
spleenMedium
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602901, gene) Transportin 1; TNPO1OMIM


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