Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_Q92988)
Protein (NX_Q92988)
Protein
Gene SymbolDLX4 to neXtProt (NX_Q92988)
DescriptionHomeobox protein DLX-4
Chromosome17
Location17q21.33 (48046334 ~ 48052321) to Ensembl
Sequene Features : Isoforms 3, Variants 32, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.multicellular organismal development
.regulation of transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 32 0
2014-09-19protein level
3 27 0
2014-05-27protein level
3 27 0
2014-02-25protein level
3 27 0
2013-12-09protein level
3 24 0
2013-11-01protein level
3 24 0
2013-09-12protein level
3 24 0
2013-08-17protein level
3 24 0
2013-07-15protein level
3 14 0
2013-06-11protein level
3 14 0
2013-02-12protein level
3 7 0
2012-12-20protein level
3 7 0
2012-10-30protein level
3 7 0
2012-10-07protein level
3 7 0
2012-08-24protein level
3 7 0
2012-07-28protein level
3 7 0
2012-06-08protein level
3 7 0
2012-05-07protein level
3 7 0
2012-04-10protein level
3 7 0
2012-01-13protein level
3 7 0
2011-12-20protein level
3 7 0
2011-11-11protein level
3 7 0
2011-08-23protein level
3 7 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q92988-1
2 7 0 26246.1982
NX_Q92988-2
0 8 0 18869.7596
NX_Q92988-3
1 4 0 12704.615
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1752755,EBI-298336 SP1  
  .definitive hemopoiesis
.embryonic process involved in female pregnancy
.embryonic skeletal system development
  + 19 more...
.HMG box domain binding
.metal ion binding
.transcription regulatory region DNA binding
  + 16 more...
.protein-DNA complex
.cytoplasm
.nucleoplasm
.nucleus
2 EBI-1752755,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
3 EBI-1752755,EBI-347263 SMAD4  
  .nephrogenic mesenchyme morphogenesis
.metanephric mesenchyme morphogenesis
.response to transforming growth factor beta
  + 49 more...
.R-SMAD binding
.I-SMAD binding
.metal ion binding
  + 9 more...
.SMAD protein complex
.activin responsive factor complex
.cytosol
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bone13
eye9
liver4
pancreas4
placenta102
skin9
uterus8
Health State
TissuesTPM*
normal9
germ cell tumor11
liver tumor10
pancreatic tumor9
primitive neuroectodermal tumor of the CNS7
retinoblastoma43
skin tumor15
soft tissue/muscle tissue tumor7
uterine tumor11
Developmental Stage
TissuesTPM*
adult14
fetus7
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
placenta5.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601911, gene) Distal-less homeobox 4; DLX4OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center