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> Protein (NX_Q92993)
Protein (NX_Q92993)
Protein
Gene SymbolKAT5 to neXtProt (NX_Q92993)
DescriptionHistone acetyltransferase KAT5
Chromosome11
Location11q13.1 (65479467 ~ 65487075) to Ensembl
Sequene Features : Isoforms 4, Variants 40, PTMs 10 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of protein acetylation
.cellular response to estradiol stimulus
.positive regulation of transcription from RNA polymerase II promoter
  + 14 more...
.repressing transcription factor binding
.androgen receptor binding
.metal ion binding
  + 2 more...
.perinuclear region of cytoplasm
.NuA4 histone acetyltransferase complex
.Piccolo NuA4 histone acetyltransferase complex
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 40 10
2014-09-19protein level
4 34 10
2014-05-27protein level
4 34 10
2014-02-25protein level
4 34 10
2013-12-09protein level
4 25 10
2013-11-01protein level
4 23 9
2013-09-12protein level
4 23 9
2013-08-17protein level
4 23 9
2013-07-15protein level
4 15 8
2013-06-11protein level
4 15 8
2013-02-12protein level
4 4 24
2012-12-20protein level
4 5 24
2012-10-30protein level
4 6 24
2012-10-07protein level
4 6 6
2012-08-24protein level
4 5 6
2012-07-28protein level
4 5 6
2012-06-08protein level
4 14 6
2012-05-07protein level
4 12 6
2012-04-10protein level
3 12 6
2012-01-13protein level
3 15 5
2011-12-20protein level
3 15 5
2011-11-11protein level
3 15 5
2011-08-23protein level
3 15 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q92993-1
0 27 0 58544.916
NX_Q92993-2
0 24 0 53043.0843
NX_Q92993-3
0 28 0 61758.6182
NX_Q92993-4
0 25 0 56256.7865
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-399080,EBI-710057 DLEU1  
  .N/A .N/A .N/A
2 EBI-399080,EBI-10176632 ZBTB14  
  .negative regulation of transcription, DNA-templated
.transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.metal ion binding
.transcription regulatory region DNA binding
.sequence-specific DNA binding
  + 2 more...
.cytoplasm
.nucleoplasm
.nucleus
3 EBI-399080,EBI-714135 STX11  
  .membrane fusion
.vesicle docking
.natural killer cell degranulation
  + 4 more...
.SNAP receptor activity
.SNARE binding
.SNARE complex
.integral component of membrane
.endomembrane system
  + 3 more...
4 EBI-399080,EBI-741602 TRIM37  
  .aggresome assembly
.protein autoubiquitination
.positive regulation of NF-kappaB transcription factor activity
  + 7 more...
.ubiquitin protein ligase activity
.protein homodimerization activity
.ubiquitin protein ligase binding
  + 5 more...
.perinuclear region of cytoplasm
.aggresome
.cytosol
  + 2 more...
5 EBI-399080,EBI-448202 GADD45G  
  .positive regulation of p38MAPK cascade
.regulation of cell cycle
.positive regulation of JNK cascade
  + 8 more...
.N/A .cytoplasm
.nucleus
6 EBI-399080,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
7 EBI-399080,EBI-1044287 ODC1  
  .small molecule metabolic process
.regulation of protein catabolic process
.cellular nitrogen compound metabolic process
  + 6 more...
.protein homodimerization activity
.ornithine decarboxylase activity
.cytosol
.cytoplasm
8 EBI-399080,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
9 EBI-399080,EBI-710431 PTPN4  
  .peptidyl-tyrosine dephosphorylation
.protein dephosphorylation
.non-membrane spanning protein tyrosine phosphatase activity .cytoplasmic side of plasma membrane
.cytoskeleton
.cytoplasm
10 EBI-399080,EBI-3505701 SOX5  
  .positive regulation of mesenchymal stem cell differentiation
.cellular response to transforming growth factor beta stimulus
.positive regulation of cartilage development
  + 10 more...
.transcription regulatory region DNA binding
.sequence-specific DNA binding transcription factor activity
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.nuclear transcription factor complex
11 EBI-399080,EBI-740098 TRIM23  
  .positive regulation of catalytic activity
.protein ubiquitination
.viral process
.small GTPase mediated signal transduction
.identical protein binding
.GDP binding
.ligase activity
  + 5 more...
.extracellular exosome
.lysosomal membrane
.nucleus
.Golgi membrane
12 EBI-399080,EBI-930964 ATXN1  
  .regulation of excitatory postsynaptic membrane potential
.nuclear export
.lung alveolus development
  + 9 more...
.protein self-association
.identical protein binding
.poly(G) binding
  + 4 more...
.intracellular membrane-bounded organelle
.nuclear inclusion body
.nuclear matrix
  + 3 more...
13 EBI-399080,EBI-10172052 KRTAP10-9  
  .N/A .N/A .keratin filament
14 EBI-399080,EBI-627047 SRSF2  
  .negative regulation of nucleic acid-templated transcription
.mRNA 3'-end processing
.gene expression
  + 6 more...
.poly(A) RNA binding
.transcription corepressor activity
.nucleotide binding
.extracellular exosome
.nuclear speck
.cytoplasm
  + 3 more...
15 EBI-399080,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
16 EBI-399080,EBI-1797287 TWIST1  
  .positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation
.cell proliferation involved in heart valve development
.negative regulation of double-strand break repair
  + 51 more...
.E-box binding
.bHLH transcription factor binding
.transcription factor binding
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.nucleus
17 EBI-399080,EBI-2341787 LONRF1  
  .N/A .zinc ion binding
.ATP-dependent peptidase activity
.N/A
18 EBI-399080,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
19 EBI-399080,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
20 EBI-399080,EBI-2549423 HMBOX1  
  .positive regulation of transcription, DNA-templated
.negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.DNA binding .cytoplasm
.nucleoplasm
.nucleus
21 EBI-399080,EBI-713786 PHC2  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 2 more...
.identical protein binding
.zinc ion binding
.DNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 2 more...
22 EBI-399080,EBI-10279993 ZNF513  
  .retina development in camera-type eye
.response to stimulus
.visual perception
  + 2 more...
.metal ion binding
.transcription regulatory region DNA binding
.DNA binding
.nucleus
23 EBI-399080,EBI-745707 GMCL1P1  
  .cell differentiation
.protein ubiquitination
.spermatogenesis
.multicellular organismal development
.N/A .nuclear matrix
24 EBI-399080,EBI-742740 ZBTB8A  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
25 EBI-399080,EBI-10171416 CCDC136  
  .N/A .N/A .integral component of membrane
.mitochondrion
26 EBI-399080,EBI-724076 MDFI  
  .trophoblast giant cell differentiation
.embryonic skeletal system morphogenesis
.negative regulation of DNA binding
  + 6 more...
.N/A .cytoplasm
.nucleus
27 EBI-399080,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
28 EBI-399080,EBI-9695448 FOXP3  
  .negative regulation of T-helper 17 cell differentiation
.T cell receptor signaling pathway
.negative regulation of immune response
  + 48 more...
.NFAT protein binding
.NF-kappaB binding
.metal ion binding
  + 9 more...
.protein complex
.cytoplasm
.nucleus
29 EBI-399080,EBI-712912 CBX8  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 3 more...
.methylated histone binding
.ubiquitin-protein transferase activity
.single-stranded RNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 3 more...
30 EBI-399080,EBI-2557363 TUFT1  
  .odontogenesis
.bone mineralization
.structural constituent of tooth enamel .cytoplasm
.extracellular region
31 EBI-399080,EBI-10239299 PIH1D3  
  .axonemal dynein complex assembly
.sperm motility
.chaperone binding .cytoplasm
32 EBI-399080,EBI-473176 KIAA1377  
  .cilium assembly
.cytoplasmic microtubule organization
.mitotic spindle organization
.N/A .ciliary base
.midbody
.centrosome
.cytoplasm
33 EBI-399080,EBI-747204 IKZF3  
  .regulation of lymphocyte differentiation
.regulation of B cell differentiation
.regulation of apoptotic process
  + 5 more...
.protein heterodimerization activity
.metal ion binding
.sequence-specific DNA binding
  + 2 more...
.plasma membrane
.cytoplasm
.nucleus
34 EBI-399080,EBI-2212028 SSX2IP  
  .regulation of cell motility
.centrosome organization
.cilium assembly
  + 3 more...
.N/A .protein complex
.ciliary basal body
.centriolar satellite
  + 3 more...
35 EBI-399080,EBI-719716 NINL  
  .organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.calcium ion binding .microtubule
.cytosol
.microtubule organizing center
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland151
ascites75
bladder33
blood57
bone marrow20
brain77
cervix247
connective tissue73
embryonic tissue65
esophagus49
eye90
heart55
intestine60
kidney52
liver34
lung68
lymph22
lymph node77
mammary gland92
muscle28
ovary68
pancreas60
placenta84
prostate52
salivary gland49
skin66
spleen74
stomach52
testis87
thymus50
thyroid85
umbilical cord72
uterus34
Health State
TissuesTPM*
normal71
adrenal tumor79
breast (mammary gland) tumor139
cervical tumor260
chondrosarcoma60
colorectal tumor44
esophageal tumor57
gastrointestinal tumor33
germ cell tumor56
glioma130
head and neck tumor7
kidney tumor43
leukemia95
liver tumor52
lung tumor68
lymphoma69
non-neoplasia93
ovarian tumor65
pancreatic tumor66
primitive neuroectodermal tumor of the CNS55
prostate cancer38
skin tumor71
soft tissue/muscle tissue tumor31
uterine tumor33
Developmental Stage
TissuesTPM*
adult61
embryoid body57
blastocyst130
neonate128
fetus62
infant85
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue24
adrenal gland29.5
appendix30.2
bone marrow43.8
cerebral cortex29.7
colon30.7
duodenum28.4
esophagus27.9
gallbladder25.6
heart muscle27.3
kidney30
liver12.3
lung36.1
lymph node34
ovary42.7
pancreas16.2
placenta37.4
prostate33.6
salivary gland29.3
skin40.9
small intestine28.5
spleen33
stomach29.1
testis44.3
thyroid gland43.4
urinary bladder30
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601409, gene) K(lysine) acetyltransferase 5; KAT5OMIM


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