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> Protein (NX_Q92997)
Protein (NX_Q92997)
Protein
Gene SymbolDVL3 to neXtProt (NX_Q92997)
DescriptionSegment polarity protein dishevelled homolog DVL-3
Chromosome3
Location3q27.1 (183873176 ~ 183891398) to Ensembl
Sequene Features : Isoforms 2, Variants 82, PTMs 13 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of canonical Wnt signaling pathway
.planar cell polarity pathway involved in neural tube closure
.cochlea morphogenesis
  + 12 more...
.protein heterodimerization activity
.beta-catenin binding
.frizzled binding
  + 2 more...
.cytosol
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 82 13
2014-09-19protein level
2 58 13
2014-05-27protein level
2 58 14
2014-02-25protein level
2 58 14
2013-12-09protein level
2 42 14
2013-11-01protein level
2 41 14
2013-09-12protein level
1 41 10
2013-08-17protein level
1 41 10
2013-07-15protein level
1 28 9
2013-06-11protein level
1 28 9
2013-02-12protein level
1 10 9
2012-12-20protein level
1 10 9
2012-10-30protein level
1 15 2
2012-10-07protein level
1 15 2
2012-08-24protein level
1 14 2
2012-07-28protein level
1 14 2
2012-06-08protein level
1 36 2
2012-05-07protein level
1 31 2
2012-04-10protein level
1 31 2
2012-01-13protein level
1 29 2
2011-12-20protein level
1 29 2
2011-11-11protein level
1 29 2
2011-08-23protein level
1 29 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q92997-1
1 21 4 78005.7046
NX_Q92997-2
1 21 4 76207.7935
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-739789,EBI-723489 DVL1  
  .positive regulation of canonical Wnt signaling pathway
.planar cell polarity pathway involved in neural tube closure
.cochlea morphogenesis
  + 28 more...
.identical protein binding
.protein kinase binding
.enzyme binding
.frizzled binding
.synapse
.neuronal cell body
.cytoplasmic vesicle
  + 8 more...
2 EBI-739789,EBI-744322 PRPF3  
  .RNA splicing
.mRNA processing
.mRNA splicing, via spliceosome
  + 2 more...
.poly(A) RNA binding
.identical protein binding
.U4/U6 x U5 tri-snRNP complex
.nuclear speck
.Cajal body
  + 4 more...
3 EBI-739789,EBI-714732 ADAP1  
  .positive regulation of GTPase activity
.regulation of GTPase activity
.cell surface receptor signaling pathway
.inositol 1,3,4,5 tetrakisphosphate binding
.zinc ion binding
.phosphatidylinositol-3,4,5-trisphosphate binding
.GTPase activator activity
.plasma membrane
.cytoplasm
.nucleus
4 EBI-739789,EBI-1211440 STOM  
  .regulation of acid-sensing ion channel activity
.activation of mitophagy in response to mitochondrial depolarization
.protein homooligomerization
.positive regulation of defense response to virus by host
.RNA polymerase binding .blood microparticle
.extracellular exosome
.membrane raft
  + 9 more...
5 EBI-739789,EBI-751621 CSNK1D  
  .positive regulation of canonical Wnt signaling pathway
.spindle assembly
.regulation of circadian rhythm
  + 13 more...
.tau-protein kinase activity
.peptide binding
.ATP binding
  + 2 more...
.perinuclear region of cytoplasm
.plasma membrane
.spindle microtubule
  + 5 more...
6 EBI-739789,EBI-749343 CSNK1E  
  .positive regulation of canonical Wnt signaling pathway
.regulation of circadian rhythm
.cellular protein localization
  + 14 more...
.poly(A) RNA binding
.ATP binding
.protein serine/threonine kinase activity
.protein kinase activity
.ribonucleoprotein complex
.cytosol
.cytoplasm
.nucleus
7 EBI-739789,EBI-724442 RWDD2B  
  .N/A .N/A .N/A
8 EBI-739789,EBI-8472267 KLF3  
  .cellular response to peptide
.multicellular organismal development
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
9 EBI-739789,EBI-5323863 LRRK2  
  .negative regulation of peroxidase activity
.regulation of synaptic vesicle exocytosis
.regulation of branching morphogenesis of a nerve
  + 64 more...
.protein kinase A binding
.ion channel binding
.protein homodimerization activity
  + 18 more...
.extracellular exosome
.membrane raft
.perikaryon
  + 25 more...
10 EBI-739789,EBI-10246152 SYT6  
  .acrosomal vesicle exocytosis
.calcium ion-dependent exocytosis of neurotransmitter
.regulation of calcium ion-dependent exocytosis
  + 2 more...
.protein homodimerization activity
.clathrin binding
.syntaxin binding
.calcium ion binding
.perinuclear endoplasmic reticulum
.synaptic vesicle membrane
.cell junction
  + 4 more...
11 EBI-739789,EBI-751248 FAM13C  
  .N/A .N/A .N/A
12 EBI-739789,EBI-2348662 PRICKLE1  
  .negative regulation of cardiac muscle cell myoblast differentiation
.negative regulation of canonical Wnt signaling pathway
.negative regulation of transcription, DNA-templated
  + 4 more...
.zinc ion binding .nuclear membrane
.cytosol
.nucleus
13 EBI-739789,EBI-2849854 YTHDC1  
  .mRNA splice site selection .N6-methyladenosine-containing RNA binding
.poly(A) RNA binding
.RNA binding
.nuclear body
.nucleus
14 EBI-739789,EBI-714067 UTP3  
  .chromatin modification
.brain development
.maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
.poly(A) RNA binding .small-subunit processome
.nucleolus
.nucleus
15 EBI-739789,EBI-398874 NXF1  
  .poly(A)+ mRNA export from nucleus
.viral process
.gene expression
.mRNA export from nucleus
.poly(A) RNA binding
.nucleocytoplasmic transporter activity
.mRNA binding
.nucleotide binding
.nuclear inclusion body
.nuclear speck
.cytosol
  + 2 more...
16 EBI-739789,EBI-716098 NOL12  
  .N/A .poly(A) RNA binding
.rRNA binding
.nucleolus
17 EBI-739789,EBI-3937015 CEP164  
  .cell division
.cilium assembly
.mitotic nuclear division
  + 4 more...
.N/A .ciliary transition fiber
.cytosol
.centriole
  + 3 more...
18 EBI-739789,EBI-1023718 LRRFIP2  
  .Wnt signaling pathway .LRR domain binding .N/A
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites50
blood24
bone111
bone marrow20
brain43
cervix103
connective tissue46
embryonic tissue75
eye95
heart33
intestine185
kidney33
larynx255
lung68
lymph node55
mammary gland112
mouth60
nerve64
ovary98
pancreas84
pharynx73
placenta113
prostate36
skin109
stomach73
testis50
thyroid450
uterus73
Health State
TissuesTPM*
normal56
adrenal tumor79
breast (mammary gland) tumor118
cervical tumor144
chondrosarcoma120
colorectal tumor248
gastrointestinal tumor59
germ cell tumor60
glioma102
head and neck tumor127
kidney tumor58
leukemia10
lung tumor87
lymphoma41
non-neoplasia41
ovarian tumor118
pancreatic tumor114
primitive neuroectodermal tumor of the CNS39
prostate cancer28
skin tumor159
soft tissue/muscle tissue tumor15
uterine tumor99
Developmental Stage
TissuesTPM*
adult104
embryoid body100
blastocyst65
fetus52
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue22.4
adrenal gland21.6
appendix24.2
bone marrow16.9
cerebral cortex21.4
colon21.4
duodenum23.1
esophagus24.4
gallbladder32
heart muscle30
kidney19.6
liver9.7
lung25.2
lymph node18.5
ovary31.3
pancreas19.6
placenta48.6
prostate27
salivary gland22.9
skin31.4
small intestine22.7
spleen26.9
stomach25.3
testis22.9
thyroid gland25.1
urinary bladder25.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601368, gene) Dishevelled 3; DVL3OMIM


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