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> Protein (NX_Q93009)
Protein (NX_Q93009)
Protein
Gene SymbolUSP7 to neXtProt (NX_Q93009)
DescriptionUbiquitin carboxyl-terminal hydrolase 7
Chromosome16
Location16p13.2 (8985951 ~ 9058371) to Ensembl
Sequene Features : Isoforms 2, Variants 108, PTMs 20 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of proteasomal protein catabolic process
.regulation of sequence-specific DNA binding transcription factor activity
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 7 more...
.ubiquitin protein ligase binding
.transcription factor binding
.protein C-terminus binding
  + 3 more...
.PML body
.nuclear body
.cytosol
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 108 20
2014-09-19protein level
2 76 20
2014-05-27protein level
1 74 20
2014-02-25protein level
1 74 20
2013-12-09protein level
1 65 20
2013-11-01protein level
1 63 15
2013-09-12protein level
1 63 15
2013-08-17protein level
1 63 15
2013-07-15protein level
1 42 6
2013-06-11protein level
1 42 6
2013-02-12protein level
1 15 9
2012-12-20protein level
1 15 9
2012-10-30protein level
1 17 9
2012-10-07protein level
1 17 9
2012-08-24protein level
1 4 9
2012-07-28protein level
1 4 9
2012-06-08protein level
1 15 9
2012-05-07protein level
1 15 9
2012-04-10protein level
1 15 9
2012-01-13protein level
1 16 9
2011-12-20protein level
1 16 9
2011-11-11protein level
1 16 9
2011-08-23protein level
1 16 9
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q93009-1
2 58 0 128219.9751
NX_Q93009-3
1 58 0 126188.2017
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-302474,EBI-398437 MDM4  
  .cellular response to hypoxia
.negative regulation of cell cycle arrest
.protein stabilization
  + 9 more...
.enzyme binding
.zinc ion binding
.nucleoplasm
.nucleus
2 EBI-302474,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
3 EBI-302474,EBI-491274 RB1  
  .negative regulation of G1/S transition of mitotic cell cycle
.hepatocyte apoptotic process
.regulation of centromere complex assembly
  + 39 more...
.phosphoprotein binding
.androgen receptor binding
.identical protein binding
  + 7 more...
.Rb-E2F complex
.PML body
.SWI/SNF complex
  + 4 more...
4 EBI-302474,EBI-3932027 MAL  
  .positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
.transmembrane transport
.apical protein localization
  + 5 more...
.structural constituent of myelin sheath
.peptidase activator activity involved in apoptotic process
.channel activity
.lipid binding
.membrane raft
.extrinsic component of membrane
.apical plasma membrane
  + 3 more...
5 EBI-302474,EBI-2341576 BMI1  
  .positive regulation of ubiquitin-protein transferase activity
.positive regulation of fibroblast proliferation
.cellular protein metabolic process
  + 8 more...
.RING-like zinc finger domain binding
.zinc ion binding
.PRC1 complex
.PcG protein complex
.cytoplasm
  + 3 more...
6 EBI-302474,EBI-2129767 PCGF2  
  .negative regulation of apoptotic signaling pathway
.cellular response to hydrogen peroxide
.embryonic skeletal system morphogenesis
  + 8 more...
.zinc ion binding
.ubiquitin-protein transferase activity
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.PRC1 complex
.PcG protein complex
.nuclear body
  + 4 more...
7 EBI-302474,EBI-347161 SMAD3  
  .positive regulation of extracellular matrix assembly
.activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.extrinsic apoptotic signaling pathway
  + 73 more...
.R-SMAD binding
.co-SMAD binding
.transcription regulatory region DNA binding
  + 21 more...
.SMAD2-SMAD3 protein complex
.SMAD protein complex
.receptor complex
  + 8 more...
8 EBI-302474,EBI-389668 MDM2  
  .negative regulation of signal transduction by p53 class mediator
.cellular response to UV-C
.cellular response to hypoxia
  + 44 more...
.ubiquitin protein ligase activity
.identical protein binding
.ubiquitin protein ligase binding
  + 5 more...
.synapse
.protein complex
.endocytic vesicle membrane
  + 6 more...
9 EBI-302474,EBI-752313 RING1  
  .camera-type eye morphogenesis
.negative regulation of transcription, DNA-templated
.cellular protein metabolic process
  + 5 more...
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.chromatin binding
.PRC1 complex
.PcG protein complex
.nuclear speck
  + 4 more...
10 EBI-302474,EBI-2864451 MEX3C  
  .activation of mitophagy in response to mitochondrial depolarization
.energy homeostasis
.regulation of fat cell differentiation
.chondrocyte hypertrophy
.poly(A) RNA binding
.ligase activity
.zinc ion binding
.cytoplasm
.nucleus
11 EBI-302474,EBI-3436472 TSPYL5  
  .cellular response to gamma radiation
.positive regulation of protein kinase B signaling
.regulation of growth
  + 3 more...
.N/A .nucleus
12 EBI-302474,EBI-764356 TBCB  
  .'de novo' posttranslational protein folding
.cellular protein metabolic process
.cell differentiation
.nervous system development
.N/A .microtubule cytoskeleton
.microtubule
.cytoplasm
.nucleoplasm
13 EBI-302474,EBI-722416 RNF2  
  .cellular protein metabolic process
.post-translational protein modification
.negative regulation of sequence-specific DNA binding transcription factor activity
  + 8 more...
.RING-like zinc finger domain binding
.ligase activity
.zinc ion binding
  + 2 more...
.MLL1 complex
.PRC1 complex
.PcG protein complex
  + 6 more...
14 EBI-302474,EBI-447677 MYD88  
  .cellular response to mechanical stimulus
.3'-UTR-mediated mRNA stabilization
.response to interleukin-1
  + 22 more...
.TIR domain binding
.identical protein binding
.death receptor binding
.endosome membrane
.plasma membrane
.cytosol
15 EBI-302474,EBI-712912 CBX8  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 3 more...
.methylated histone binding
.ubiquitin-protein transferase activity
.single-stranded RNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 3 more...
16 EBI-302474,EBI-77321 DAXX  
  .positive regulation of apoptotic signaling pathway
.positive regulation of neuron death
.negative regulation of transcription, DNA-templated
  + 13 more...
.androgen receptor binding
.protein N-terminus binding
.protein homodimerization activity
  + 10 more...
.SWI/SNF superfamily-type complex
.PML body
.cytosol
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites175
bladder100
blood57
bone139
bone marrow61
brain47
cervix82
connective tissue33
ear124
embryonic tissue117
esophagus99
eye191
heart100
intestine125
kidney75
larynx170
liver92
lung140
lymph135
lymph node467
mammary gland178
mouth15
muscle84
ovary68
pancreas93
parathyroid48
pharynx24
placenta70
prostate147
salivary gland148
skin109
spleen74
stomach114
testis181
thymus188
thyroid107
tonsil352
trachea38
umbilical cord72
uterus103
vascular96
Health State
TissuesTPM*
normal97
adrenal tumor158
bladder carcinoma56
breast (mammary gland) tumor107
chondrosarcoma96
colorectal tumor133
esophageal tumor115
gastrointestinal tumor126
germ cell tumor121
glioma102
head and neck tumor74
kidney tumor43
leukemia84
liver tumor156
lung tumor87
lymphoma110
non-neoplasia144
ovarian tumor91
pancreatic tumor85
primitive neuroectodermal tumor of the CNS31
prostate cancer173
retinoblastoma86
skin tumor71
soft tissue/muscle tissue tumor87
uterine tumor110
Developmental Stage
TissuesTPM*
adult119
embryoid body100
blastocyst130
neonate64
fetus98
juvenile179
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue34.4
adrenal gland34.6
appendix55
bone marrow69.7
cerebral cortex40.7
colon50.3
duodenum43.6
esophagus49.1
gallbladder37.4
heart muscle27.7
kidney31.1
liver26
lung33.9
lymph node76.3
ovary36.3
pancreas21.7
placenta41.3
prostate38
salivary gland27.4
skin49.8
small intestine44.8
spleen51.5
stomach47.1
testis75.6
thyroid gland40.5
urinary bladder41.1
Tissues
TissuesExpression level
adrenal glandMedium
appendixLow
bone marrowMedium
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexHigh
cervix, uterineMedium
colonMedium
duodenumLow
endometrium 1Medium
endometrium 2Low
epididymisMedium
esophagusHigh
fallopian tubeMedium
gallbladderMedium
heart muscleMedium
hippocampusHigh
kidneyMedium
lateral ventricleHigh
liverLow
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaLow
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaHigh
prostateLow
rectumMedium
salivary glandHigh
seminal vesicleLow
skeletal muscleHigh
skin 1Low
skin 2Low
small intestineLow
smooth muscleHigh
soft tissue 1Medium
soft tissue 2Low
spleenMedium
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandMedium
tonsilLow
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602519, gene) Ubiquitin-specific protease 7; USP7OMIM


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