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> Protein (NX_Q969F2)
Protein (NX_Q969F2)
Protein
Gene SymbolNKD2 to neXtProt (NX_Q969F2)
DescriptionProtein naked cuticle homolog 2
Chromosome5
Location5p15.33 (1008944 ~ 1039058) to Ensembl
Sequene Features : Isoforms 2, Variants 64, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of canonical Wnt signaling pathway
.positive regulation of establishment of protein localization to plasma membrane
.protein targeting to plasma membrane
  + 5 more...
.ubiquitin protein ligase binding
.growth factor binding
.calcium ion binding
.cell periphery
.cytoplasmic vesicle
.basolateral plasma membrane
.cytoplasmic membrane-bounded vesicle
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 64 7
2014-09-19protein level
2 56 7
2014-05-27protein level
2 56 7
2014-02-25protein level
2 56 7
2013-12-09protein level
2 38 7
2013-11-01protein level
2 33 7
2013-09-12protein level
2 33 7
2013-08-17protein level
2 33 7
2013-07-15protein level
2 28 7
2013-06-11protein level
2 28 7
2013-02-12protein level
2 13 2
2012-12-20protein level
2 13 2
2012-10-30protein level
2 17 2
2012-10-07protein level
2 17 1
2012-08-24protein level
2 17 1
2012-07-28protein level
2 17 1
2012-06-08protein level
2 18 1
2012-05-07protein level
2 16 1
2012-04-10protein level
2 16 1
2012-01-13protein level
2 8 1
2011-12-20protein level
2 8 1
2011-11-11protein level
2 8 1
2011-08-23protein level
2 8 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q969F2-1
9 13 0 50024.6624
NX_Q969F2-2
2 13 0 34292.6167
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1538629,EBI-947779 RCHY1  
  .error-free translesion synthesis
.protein autoubiquitination
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
  + 5 more...
.protein homodimerization activity
.ligase activity
.zinc ion binding
  + 2 more...
.nuclear speck
.cytoplasm
.nucleoplasm
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood8
bone27
brain2
embryonic tissue18
eye23
intestine4
kidney4
liver4
lung2
mammary gland46
placenta10
spleen18
testis9
uterus4
Health State
TissuesTPM*
normal4
breast (mammary gland) tumor75
chondrosarcoma24
colorectal tumor8
germ cell tumor18
kidney tumor14
leukemia10
lung tumor9
retinoblastoma21
uterine tumor11
Developmental Stage
TissuesTPM*
adult10
embryoid body42
blastocyst16
fetus3
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue3
adrenal gland5.5
appendix2.4
cerebral cortex3
colon1.3
duodenum2.6
esophagus5.1
gallbladder3.8
heart muscle2.2
kidney2.8
liver1.4
lung25.3
lymph node2
pancreas2.2
placenta4.8
prostate3.2
salivary gland4.6
skin15.6
small intestine2.7
spleen11.4
testis9.9
urinary bladder4.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607852, gene) Naked cuticle, drosophila, homolog of, 2; NKD2OMIM


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