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> Protein (NX_Q969G3)
Protein (NX_Q969G3)
Protein
Gene SymbolSMARCE1 to neXtProt (NX_Q969G3)
DescriptionSWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
Chromosome17
Location17q21.2 (38781214 ~ 38804760) to Ensembl
Sequene Features : Isoforms 6, Variants 41, PTMs 13 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of transcription, DNA-templated
.ATP-dependent chromatin remodeling
.metabolic process
  + 4 more...
.protein N-terminus binding
.ligand-dependent nuclear receptor binding
.N-acetyltransferase activity
  + 4 more...
.nBAF complex
.npBAF complex
.protein complex
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
6 41 13
2014-09-19protein level
6 29 13
2014-05-27protein level
6 29 13
2014-02-25protein level
6 29 12
2013-12-09protein level
6 24 13
2013-11-01protein level
6 23 8
2013-09-12protein level
6 23 8
2013-08-17protein level
3 23 8
2013-07-15protein level
2 15 2
2013-06-11protein level
2 15 2
2013-02-12protein level
2 5 4
2012-12-20protein level
2 5 4
2012-10-30protein level
2 7 4
2012-10-07protein level
2 7 2
2012-08-24protein level
2 6 2
2012-07-28protein level
2 5 2
2012-06-08protein level
2 1 2
2012-05-07protein level
2 1 2
2012-04-10protein level
2 1 2
2012-01-13protein level
2 1 2
2011-12-20protein level
2 5 2
2011-11-11protein level
2 5 1
2011-08-23protein level
2 5 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q969G3-1
0 17 0 46620.4565
NX_Q969G3-2
0 16 0 41753.5785
NX_Q969G3-3
0 14 0 39235.7431
NX_Q969G3-4
0 15 0 42809.6709
NX_Q969G3-5
0 14 0 37942.7929
NX_Q969G3-6
0 13 0 34368.8651
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-455078,EBI-714135 STX11  
  .membrane fusion
.vesicle docking
.natural killer cell degranulation
  + 4 more...
.SNAP receptor activity
.SNARE binding
.SNARE complex
.integral component of membrane
.endomembrane system
  + 3 more...
2 EBI-455078,EBI-2548868 CCDC172  
  .N/A .N/A .N/A
3 EBI-455078,EBI-739566 KRT15  
  .activation of mitophagy in response to mitochondrial depolarization
.epidermis development
.scaffold protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.intermediate filament
.nucleus
4 EBI-455078,EBI-347978 NUP62  
  .regulation of cellular response to heat
.transmembrane transport
.mRNA transport
  + 34 more...
.thyroid hormone receptor binding
.ubiquitin binding
.SH2 domain binding
  + 3 more...
.Flemming body
.pore complex
.intracellular membrane-bounded organelle
  + 7 more...
5 EBI-455078,EBI-359793 TXLNA  
  .activation of mitophagy in response to mitochondrial depolarization
.B cell activation
.cell proliferation
.exocytosis
.high molecular weight B cell growth factor receptor binding
.cytokine activity
.membrane
.cytoplasm
.extracellular region
6 EBI-455078,EBI-10172052 KRTAP10-9  
  .N/A .N/A .keratin filament
7 EBI-455078,EBI-1181367 CDR2  
  .N/A .N/A .cytoplasm
8 EBI-455078,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
9 EBI-455078,EBI-375576 EPS8  
  .actin polymerization-dependent cell motility
.actin crosslink formation
.actin filament bundle assembly
  + 13 more...
.Rac GTPase binding
.SH3/SH2 adaptor activity
.actin binding
.extracellular exosome
.ruffle membrane
.stereocilium
  + 6 more...
10 EBI-455078,EBI-749285 RALBP1  
  .regulation of small GTPase mediated signal transduction
.positive regulation of GTPase activity
.regulation of GTPase activity
  + 5 more...
.Rac GTPase binding
.ATPase activity, coupled to movement of substances
.Ral GTPase binding
  + 2 more...
.membrane
.cytosol
11 EBI-455078,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
12 EBI-455078,EBI-739936 TRIP10  
  .regulation of small GTPase mediated signal transduction
.actin cytoskeleton organization
.small GTPase mediated signal transduction
  + 3 more...
.identical protein binding
.lipid binding
.extracellular exosome
.perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
  + 9 more...
13 EBI-455078,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
14 EBI-455078,EBI-637818 ARID2  
  .chromatin modification
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.nucleosome disassembly
.metal ion binding
.DNA binding
.plasma membrane
.nucleoplasm
15 EBI-455078,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
16 EBI-455078,EBI-726876 RINT1  
  .regulation of signal transduction involved in mitotic G2 DNA damage checkpoint
.regulation of ER to Golgi vesicle-mediated transport
.Golgi vesicle transport
  + 2 more...
.N/A .endoplasmic reticulum membrane
.endoplasmic reticulum
17 EBI-455078,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
18 EBI-455078,EBI-6872807 SYCE1  
  .cell division
.synaptonemal complex assembly
.N/A .central element
19 EBI-455078,EBI-739895 USHBP1  
  .N/A .PDZ domain binding .N/A
20 EBI-455078,EBI-739624 CEP70  
  .organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .nuclear membrane
.cytosol
.centrosome
  + 2 more...
21 EBI-455078,EBI-2548751 MIPOL1  
  .N/A .N/A .nucleus
22 EBI-455078,EBI-488533 ING5  
  .positive regulation of apoptotic signaling pathway
.negative regulation of growth
.positive regulation of transcription, DNA-templated
  + 7 more...
.methylated histone binding
.zinc ion binding
.chromatin binding
.MOZ/MORF histone acetyltransferase complex
.nucleoplasm
.nucleus
23 EBI-455078,EBI-752007 JAKMIP2  
  .N/A .N/A .Golgi apparatus
24 EBI-455078,EBI-748896 MRFAP1L1  
  .N/A .identical protein binding .N/A
25 EBI-455078,EBI-10171416 CCDC136  
  .N/A .N/A .integral component of membrane
.mitochondrion
26 EBI-455078,EBI-743488 CEP170P1  
  .N/A .identical protein binding .N/A
27 EBI-455078,EBI-741977 CEP63  
  .cell division
.spindle assembly
.signal transduction in response to DNA damage
  + 6 more...
.N/A .cytosol
.centriole
.centrosome
.spindle pole
28 EBI-455078,EBI-413317 SPAG5  
  .regulation of attachment of spindle microtubules to kinetochore
.cell division
.chromosome segregation
  + 2 more...
.N/A .mitotic spindle
.microtubule plus-end
.midbody
  + 7 more...
29 EBI-455078,EBI-2125614 KIFC3  
  .epithelial cell-cell adhesion
.zonula adherens maintenance
.metabolic process
  + 3 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.cytoplasmic vesicle membrane
.zonula adherens
  + 4 more...
30 EBI-455078,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
31 EBI-455078,EBI-714781 BRMS1  
  .positive regulation of anoikis
.positive regulation of protein deacetylation
.negative regulation of transcription, DNA-templated
  + 6 more...
.NF-kappaB binding
.histone deacetylase binding
.Sin3-type complex
.cytoplasm
.nucleoplasm
.nucleus
32 EBI-455078,EBI-394607 MED4  
  .positive regulation of transcription, DNA-templated
.androgen receptor signaling pathway
.intracellular steroid hormone receptor signaling pathway
  + 3 more...
.thyroid hormone receptor binding
.vitamin D receptor binding
.ligand-dependent nuclear receptor transcription coactivator activity
  + 3 more...
.mediator complex
.membrane
.nucleoplasm
.nucleus
33 EBI-455078,EBI-1105213 TFIP11  
  .biomineral tissue development
.RNA processing
.regulation of transcription, DNA-templated
  + 2 more...
.DNA binding .catalytic step 2 spliceosome
.U2-type post-mRNA release spliceosomal complex
.nuclear speck
  + 3 more...
34 EBI-455096,EBI-926563 RCOR1  
  .histone H4 deacetylation
.negative regulation of transcription, DNA-templated
.viral process
  + 3 more...
.transcription regulatory region DNA binding
.chromatin binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.transcriptional repressor complex
.nucleoplasm
.nucleus
35 EBI-455078,EBI-720048 EXOC7  
  .membrane organization
.cellular protein metabolic process
.protein transport
  + 2 more...
.N/A .centriolar satellite
.growth cone membrane
.membrane
  + 4 more...
36 EBI-455078,EBI-10187270 AMOTL2  
  .hippo signaling
.Wnt signaling pathway
.N/A .recycling endosome
.cytoplasmic vesicle
.apical plasma membrane
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland60
ascites125
bladder100
blood204
bone111
bone marrow61
brain138
cervix123
connective tissue114
embryonic tissue220
esophagus198
eye119
heart44
intestine68
kidney137
larynx42
liver24
lung92
lymph112
lymph node89
mammary gland105
mouth211
muscle65
nerve128
ovary39
pancreas65
pharynx171
pituitary gland60
placenta116
prostate126
salivary gland148
skin99
spleen318
stomach125
testis52
thymus163
thyroid128
trachea135
umbilical cord72
uterus155
vascular309
Health State
TissuesTPM*
normal119
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor107
cervical tumor173
chondrosarcoma144
colorectal tumor79
esophageal tumor231
gastrointestinal tumor126
germ cell tumor186
glioma27
head and neck tumor134
kidney tumor101
leukemia158
liver tumor31
lung tumor48
lymphoma96
non-neoplasia82
ovarian tumor52
pancreatic tumor57
primitive neuroectodermal tumor of the CNS181
prostate cancer154
retinoblastoma172
skin tumor71
soft tissue/muscle tissue tumor135
uterine tumor99
Developmental Stage
TissuesTPM*
adult96
embryoid body228
blastocyst162
neonate160
fetus184
infant42
juvenile233
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue55.4
adrenal gland45.1
appendix56.4
bone marrow45.5
cerebral cortex35.5
colon59.4
duodenum57.3
esophagus66.4
gallbladder74.3
heart muscle59.5
kidney51.2
liver33.7
lung59.8
lymph node80.4
ovary95.1
pancreas24
placenta73
prostate60
salivary gland39.6
skin49.2
small intestine54.7
spleen62.7
stomach47.4
testis49.9
thyroid gland69
urinary bladder86.3
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowHigh
breastMedium
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonMedium
duodenumHigh
endometrium 1High
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderHigh
heart muscleMedium
hippocampusHigh
kidneyMedium
lateral ventricleMedium
liverLow
lungMedium
lymph nodeHigh
nasopharynxHigh
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaHigh
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2High
small intestineHigh
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenHigh
stomach 1High
stomach 2High
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603111, gene) Swi/snf-related, matrix-associated, actin-dependent regulator of chromatin,OMIM
2(#607174, phenotype) Meningioma, familial, susceptibility toOMIM


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