Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_Q969H4)
Protein (NX_Q969H4)
Protein
Gene SymbolCNKSR1 to neXtProt (NX_Q969H4)
DescriptionConnector enhancer of kinase suppressor of ras 1
Chromosome1
Location1p36.11 (26503894 ~ 26516377) to Ensembl
Sequene Features : Isoforms 2, Variants 99, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.Rho protein signal transduction
.Ras protein signal transduction
.transmembrane receptor protein tyrosine kinase signaling pathway
.protein binding, bridging .cell cortex
.cell-cell junction
.plasma membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 99 4
2014-09-19protein level
2 74 4
2014-05-27protein level
2 74 4
2014-02-25protein level
2 73 4
2013-12-09protein level
2 58 4
2013-11-01protein level
2 55 4
2013-09-12protein level
2 55 4
2013-08-17protein level
2 55 4
2013-07-15protein level
2 43 4
2013-06-11protein level
2 43 4
2013-02-12protein level
2 30 6
2012-12-20protein level
2 28 6
2012-10-30protein level
2 32 6
2012-10-07protein level
2 32 3
2012-08-24protein level
2 31 3
2012-07-28protein level
2 31 3
2012-06-08protein level
2 35 3
2012-05-07protein level
2 30 3
2012-04-10protein level
2 30 3
2012-01-13protein level
2 13 3
2011-12-20protein level
2 13 3
2011-11-11protein level
2 13 3
2011-08-23protein level
2 13 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q969H4-1
1 25 0 79655.963
NX_Q969H4-2
1 25 0 78740.5424
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-741671,EBI-741648 CYTH3  
  .establishment of epithelial cell polarity
.Golgi vesicle transport
.positive regulation of cell adhesion
  + 2 more...
.phosphatidylinositol-3,4,5-trisphosphate binding
.ARF guanyl-nucleotide exchange factor activity
.extrinsic component of cytoplasmic side of plasma membrane
.plasma membrane
.cytosol
.ruffle
2 EBI-741671,EBI-714158 PIN1  
  .negative regulation of cell motility
.negative regulation of ERK1 and ERK2 cascade
.regulation of pathway-restricted SMAD protein phosphorylation
  + 11 more...
.phosphothreonine binding
.phosphoserine binding
.GTPase activating protein binding
  + 2 more...
.midbody
.nuclear speck
.cytoplasm
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites50
bladder100
brain6
embryonic tissue23
esophagus198
heart44
intestine47
kidney28
liver4
lung26
mammary gland72
mouth136
ovary49
pancreas28
parathyroid48
placenta102
prostate47
skin4
spleen37
testis20
thymus25
uterus17
Health State
TissuesTPM*
normal22
bladder carcinoma170
breast (mammary gland) tumor53
colorectal tumor53
esophageal tumor173
gastrointestinal tumor16
germ cell tumor49
head and neck tumor67
liver tumor10
lung tumor29
lymphoma55
ovarian tumor52
pancreatic tumor19
prostate cancer19
uterine tumor22
Developmental Stage
TissuesTPM*
adult35
embryoid body28
blastocyst16
fetus7
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
appendix4.4
cerebral cortex1.3
colon14.2
duodenum18.5
esophagus14.1
gallbladder7
kidney5.2
lung14.9
lymph node2.8
ovary2.2
pancreas9.2
placenta13.2
prostate12.9
salivary gland14.2
skin23.5
small intestine18
spleen1.5
stomach17.8
testis2.6
thyroid gland17.6
urinary bladder11.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603272, gene) Connector enhancer of ksr 1; CNKSR1OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center