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> Protein (NX_Q969J2)
Protein (NX_Q969J2)
Protein
Gene SymbolZKSCAN4 to neXtProt (NX_Q969J2)
DescriptionZinc finger protein with KRAB and SCAN domains 4
Chromosome6
Location6p22.1 (28212401 ~ 28227011) to Ensembl
Sequene Features : Isoforms 1, Variants 53, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.transcription, DNA-templated .metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 53 0
2014-09-19protein level
1 47 0
2014-05-27protein level
1 47 1
2014-02-25protein level
1 47 1
2013-12-09protein level
1 29 1
2013-11-01protein level
1 29 1
2013-09-12protein level
1 29 1
2013-08-17protein level
1 29 1
2013-07-15protein level
1 16 1
2013-06-11protein level
1 16 1
2013-02-12protein level
1 8 1
2012-12-20protein level
1 7 1
2012-10-30protein level
1 14 1
2012-10-07protein level
1 14 1
2012-08-24protein level
1 12 1
2012-07-28protein level
1 12 1
2012-06-08protein level
1 12 1
2012-05-07protein level
1 12 1
2012-04-10protein level
1 12 1
2012-01-13protein level
1 7 1
2011-12-20protein level
1 7 1
2011-11-11protein level
1 7 1
2011-08-23protein level
1 7 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q969J2-1
23 0 5 61540.2403
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2818641,EBI-745846 SCAND1  
  .transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.identical protein binding
.transcription coactivator activity
.sequence-specific DNA binding transcription factor activity
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.nucleus
2 EBI-2818641,EBI-743906 ZNF496  
  .positive regulation of transcription, DNA-templated
.transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.metal ion binding
.DNA binding
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.nuclear body
.nucleus
3 EBI-2818641,EBI-1044504 LXN  
  .detection of temperature stimulus involved in sensory perception of pain
.inflammatory response
.heparin binding
.metalloendopeptidase inhibitor activity
.extracellular exosome
.cytoplasm
4 EBI-2818641,EBI-739510 TRIM39  
  .positive regulation of apoptotic signaling pathway
.negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.protein ubiquitination
.apoptotic process
.identical protein binding
.ligase activity
.zinc ion binding
.cytosol
.mitochondrion
5 EBI-2818641,EBI-10311131 CABP5  
  .signal transduction .calcium ion binding .cytosol
6 EBI-2818641,EBI-743851 ZKSCAN7  
  .transcription, DNA-templated .metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood65
bone13
brain17
cervix82
connective tissue13
embryonic tissue18
eye4
heart11
kidney28
lung23
lymph node11
mammary gland6
mouth30
prostate5
skin28
spleen18
stomach10
testis39
tonsil58
trachea38
uterus12
Health State
TissuesTPM*
normal15
breast (mammary gland) tumor10
chondrosarcoma36
germ cell tumor45
glioma9
head and neck tumor14
kidney tumor43
lymphoma13
non-neoplasia10
primitive neuroectodermal tumor of the CNS15
skin tumor7
uterine tumor11
Developmental Stage
TissuesTPM*
adult15
embryoid body28
blastocyst16
neonate32
fetus14
infant127
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue2.4
adrenal gland2.6
appendix4
bone marrow1.3
cerebral cortex3.2
colon3.6
duodenum4
esophagus2.2
gallbladder3.1
heart muscle2.4
kidney3.2
liver1.5
lung3.4
lymph node7.1
ovary5
placenta4.2
prostate3.1
salivary gland3
skin3.3
small intestine3.4
spleen7.9
stomach3.1
testis11.8
thyroid gland3.6
urinary bladder5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*611643, gene) Zinc finger protein with krab and scan domains 4; ZKSCAN4OMIM


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