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> Protein (NX_Q969K3)
Protein (NX_Q969K3)
Protein
Gene SymbolRNF34 to neXtProt (NX_Q969K3)
DescriptionE3 ubiquitin-protein ligase RNF34
Chromosome12
Location12q24.31 (121837844 ~ 121868389) to Ensembl
Sequene Features : Isoforms 2, Variants 41, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
.regulation of oxygen metabolic process
.negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
  + 7 more...
.phosphatidylinositol phosphate binding
.ubiquitin protein ligase activity
.ubiquitin protein ligase binding
  + 3 more...
.nuclear speck
.endomembrane system
.plasma membrane
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 41 2
2014-09-19protein level
2 33 2
2014-05-27protein level
2 33 2
2014-02-25protein level
2 33 2
2013-12-09protein level
2 21 2
2013-11-01protein level
2 21 2
2013-09-12protein level
2 21 2
2013-08-17protein level
2 21 2
2013-07-15protein level
2 15 2
2013-06-11protein level
2 15 2
2013-02-12protein level
2 6 4
2012-12-20protein level
2 8 4
2012-10-30protein level
2 10 4
2012-10-07protein level
2 10 2
2012-08-24protein level
2 10 2
2012-07-28protein level
2 9 2
2012-06-08protein level
2 13 2
2012-05-07protein level
2 12 2
2012-04-10protein level
2 12 2
2012-01-13protein level
2 17 2
2011-12-20protein level
2 17 2
2011-11-11protein level
2 17 2
2011-08-23protein level
2 17 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q969K3-1
0 15 1 41613.3908
NX_Q969K3-2
0 15 1 41769.4913
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2340642,EBI-78060 CASP8  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
  + 55 more...
.cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.cysteine-type endopeptidase activity involved in apoptotic process
.scaffold protein binding
  + 5 more...
.ripoptosome
.membrane raft
.cell body
  + 11 more...
2 EBI-2340642,EBI-743771 APPBP2  
  .intracellular transport
.metabolic process
.intracellular protein transport
.microtubule motor activity .cytoplasmic vesicle membrane
.microtubule associated complex
.microtubule
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
bladder33
blood106
bone125
bone marrow61
brain74
cervix123
connective tissue20
ear62
embryonic tissue79
esophagus49
eye43
heart134
intestine73
kidney66
liver38
lung62
lymph node55
mammary gland39
mouth30
muscle18
nerve64
ovary78
pancreas51
pharynx147
placenta31
prostate52
skin75
stomach52
testis103
thymus62
thyroid42
trachea19
umbilical cord72
uterus64
vascular174
Health State
TissuesTPM*
normal73
breast (mammary gland) tumor42
cervical tumor28
chondrosarcoma120
colorectal tumor79
esophageal tumor57
gastrointestinal tumor33
germ cell tumor72
glioma27
head and neck tumor29
kidney tumor72
leukemia74
liver tumor83
lung tumor29
lymphoma96
non-neoplasia51
ovarian tumor78
pancreatic tumor28
primitive neuroectodermal tumor of the CNS70
prostate cancer57
retinoblastoma64
skin tumor47
soft tissue/muscle tissue tumor55
uterine tumor55
Developmental Stage
TissuesTPM*
adult56
embryoid body57
blastocyst97
neonate193
fetus57
infant170
juvenile161
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue11.8
adrenal gland13.2
appendix23.4
bone marrow8.5
cerebral cortex18.4
colon19.5
duodenum20.2
esophagus13.8
gallbladder19
heart muscle14.5
kidney12.5
liver7.6
lung14
lymph node32
ovary13.7
pancreas7.8
placenta12.9
prostate12.9
salivary gland10.8
skin14.1
small intestine17.7
spleen22
stomach18.9
testis27.8
thyroid gland15
urinary bladder20.9
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*608299, gene) Ring finger protein 34; RNF34OMIM


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