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> Protein (NX_Q969S2)
Protein (NX_Q969S2)
Protein
Gene SymbolNEIL2 to neXtProt (NX_Q969S2)
DescriptionEndonuclease 8-like 2
Chromosome8
Location8p23.1 (11627148 ~ 11644855) to Ensembl
Sequene Features : Isoforms 4, Variants 45, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.depyrimidination
.nucleotide-excision repair
.base-excision repair, AP site formation
  + 2 more...
.hydrolase activity, hydrolyzing N-glycosyl compounds
.zinc ion binding
.DNA-(apurinic or apyrimidinic site) lyase activity
.damaged DNA binding
.spindle microtubule
.cytoplasm
.nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 45 2
2014-09-19protein level
4 39 2
2014-05-27protein level
4 39 2
2014-02-25protein level
4 39 2
2013-12-09protein level
4 26 2
2013-11-01protein level
4 26 2
2013-09-12protein level
4 26 2
2013-08-17protein level
4 26 2
2013-07-15protein level
4 23 2
2013-06-11protein level
4 23 2
2013-02-12protein level
4 18 5
2012-12-20protein level
4 17 5
2012-10-30protein level
4 20 5
2012-10-07protein level
4 20 2
2012-08-24protein level
4 20 2
2012-07-28protein level
4 20 2
2012-06-08protein level
4 27 2
2012-05-07protein level
4 27 2
2012-04-10protein level
3 27 2
2012-01-13protein level
3 14 2
2011-12-20protein level
3 14 2
2011-11-11protein level
3 14 2
2011-08-23protein level
3 14 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q969S2-1
0 17 0 36803.2946
NX_Q969S2-2
0 16 0 35224.5353
NX_Q969S2-3
1 13 0 29911.6343
NX_Q969S2-4
1 11 0 24120.0834
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10281234,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
2 EBI-10281234,EBI-2864512 MEOX1  
  .sclerotome development
.somite development
.hematopoietic stem cell differentiation
  + 2 more...
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.chromatin binding
  + 3 more...
.cytoplasm
.nucleus
3 EBI-10281234,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
bladder66
blood40
bone83
bone marrow61
brain45
cervix103
connective tissue6
embryonic tissue28
esophagus49
eye23
heart33
intestine17
kidney28
liver9
lung20
lymph node22
mammary gland19
mouth15
muscle37
pancreas42
placenta10
prostate31
skin33
spleen18
testis52
thymus25
tonsil58
uterus21
vascular77
Health State
TissuesTPM*
normal32
breast (mammary gland) tumor32
cervical tumor28
chondrosarcoma60
colorectal tumor17
esophageal tumor57
germ cell tumor34
glioma37
head and neck tumor7
leukemia74
liver tumor10
lung tumor19
lymphoma27
primitive neuroectodermal tumor of the CNS62
prostate cancer28
retinoblastoma21
skin tumor31
soft tissue/muscle tissue tumor31
Developmental Stage
TissuesTPM*
adult23
embryoid body28
blastocyst16
neonate32
fetus35
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue8.8
adrenal gland17.8
appendix7.2
bone marrow2
cerebral cortex16
colon5.8
duodenum2.9
esophagus5.9
gallbladder6.6
heart muscle10
kidney8.6
liver6.3
lung7.8
lymph node7.6
ovary10.5
pancreas3
placenta6.3
prostate9.3
salivary gland7.8
skin14.6
small intestine3.1
spleen9.8
stomach4.1
testis27.5
thyroid gland13.3
urinary bladder7.7
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*608933, gene) Endonuclease viii-like 2; NEIL2OMIM


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