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> Protein (NX_Q969T4)
Protein (NX_Q969T4)
Protein
Gene SymbolUBE2E3 to neXtProt (NX_Q969T4)
DescriptionUbiquitin-conjugating enzyme E2 E3
Chromosome2
Location2q31.3 (181831975 ~ 181941312) to Ensembl
Sequene Features : Isoforms 1, Variants 28, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein K11-linked ubiquitination
.protein K48-linked ubiquitination
.protein K63-linked ubiquitination
.regulation of growth
.ligase activity
.ATP binding
.ubiquitin-protein transferase activity
.cytoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 28 2
2014-09-19protein level
1 20 2
2014-05-27protein level
1 20 4
2014-02-25protein level
1 20 4
2013-12-09protein level
1 16 4
2013-11-01protein level
1 15 4
2013-09-12protein level
1 15 5
2013-08-17protein level
1 15 5
2013-07-15protein level
1 8 3
2013-06-11protein level
1 8 3
2013-02-12protein level
1 2 5
2012-12-20protein level
1 2 5
2012-10-30protein level
1 2 5
2012-10-07protein level
1 2 5
2012-08-24protein level
1 1 5
2012-07-28protein level
1 1 5
2012-06-08protein level
1 10 5
2012-05-07protein level
1 10 5
2012-04-10protein level
1 10 5
2012-01-13protein level
1 10 5
2011-12-20protein level
1 10 5
2011-11-11protein level
1 10 4
2011-08-23protein level
1 10 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q969T4-1
5 0 4 22898.3811
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-348496,EBI-2340316 MID1  
  .interferon-gamma-mediated signaling pathway
.protein localization to microtubule
.positive regulation of stress-activated MAPK cascade
  + 4 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 5 more...
.microtubule associated complex
.microtubule
.cytosol
.spindle
2 EBI-348496,EBI-2340249 RNF185  
  .protein ubiquitination
.autophagy
.ligase activity
.zinc ion binding
.integral component of membrane
.endoplasmic reticulum membrane
.mitochondrial outer membrane
3 EBI-348496,EBI-348482 RNF5  
  .regulation of autophagic vacuole assembly
.ER-associated misfolded protein catabolic process
.protein K48-linked ubiquitination
  + 5 more...
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.mitochondrial membrane
.integral component of membrane
.endoplasmic reticulum membrane
4 EBI-348496,EBI-739510 TRIM39  
  .positive regulation of apoptotic signaling pathway
.negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.protein ubiquitination
.apoptotic process
.identical protein binding
.ligase activity
.zinc ion binding
.cytosol
.mitochondrion
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites25
bladder100
blood32
bone97
bone marrow41
brain50
cervix103
connective tissue489
ear124
embryonic tissue145
eye119
heart223
intestine43
kidney42
larynx42
liver9
lung8
mouth15
muscle9
pharynx24
placenta7
skin4
stomach10
uterus25
vascular19
Health State
TissuesTPM*
normal58
adrenal tumor79
bladder carcinoma113
cervical tumor57
chondrosarcoma120
colorectal tumor26
gastrointestinal tumor84
germ cell tumor34
glioma121
head and neck tumor74
kidney tumor72
leukemia42
liver tumor83
lung tumor68
lymphoma27
non-neoplasia31
ovarian tumor13
pancreatic tumor161
primitive neuroectodermal tumor of the CNS102
prostate cancer48
retinoblastoma193
skin tumor95
soft tissue/muscle tissue tumor558
uterine tumor99
Developmental Stage
TissuesTPM*
adult81
embryoid body157
blastocyst146
fetus95
infant85
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue24.6
adrenal gland25.2
appendix24.4
bone marrow16
cerebral cortex28.7
colon28.8
duodenum24.1
esophagus21.8
gallbladder35.6
heart muscle20.8
kidney33.9
liver17.1
lung21.6
lymph node20
ovary25.3
pancreas14.4
placenta21.5
prostate22.6
salivary gland21
skin26.2
small intestine23.9
spleen18.3
stomach28.8
testis33.1
thyroid gland31.9
urinary bladder33.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604151, gene) Ubiquitin-conjugating enzyme e2e 3; UBE2E3OMIM


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