Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_Q969U6)
Protein (NX_Q969U6)
Protein
Gene SymbolFBXW5 to neXtProt (NX_Q969U6)
DescriptionF-box/WD repeat-containing protein 5
Chromosome9
Location9q34.3 (139834887 ~ 139839148) to Ensembl
Sequene Features : Isoforms 2, Variants 73, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.centrosome duplication
.proteasome-mediated ubiquitin-dependent protein catabolic process
.SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
  + 2 more...
.protein kinase binding .Cul4-RING E3 ubiquitin ligase complex
.SCF ubiquitin ligase complex
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 73 5
2014-09-19protein level
2 60 5
2014-05-27protein level
2 60 5
2014-02-25protein level
2 60 5
2013-12-09protein level
2 41 5
2013-11-01protein level
2 39 4
2013-09-12protein level
2 39 4
2013-08-17protein level
2 39 4
2013-07-15protein level
2 29 2
2013-06-11protein level
2 29 2
2013-02-12protein level
2 22 2
2012-12-20protein level
2 22 2
2012-10-30protein level
2 22 2
2012-10-07protein level
2 22 1
2012-08-24protein level
2 22 1
2012-07-28protein level
2 21 1
2012-06-08protein level
2 4 1
2012-05-07protein level
2 4 1
2012-04-10protein level
2 4 1
2012-01-13protein level
2 3 0
2011-12-20protein level
2 3 0
2011-11-11protein level
2 3 0
2011-08-23protein level
2 3 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q969U6-1
10 14 0 63881.875
NX_Q969U6-2
1 14 0 42157.8335
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-741068,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
2 EBI-741068,EBI-10171774 KRTAP10-8  
  .N/A .N/A .keratin filament
3 EBI-741068,EBI-307486 SKP1  
  .regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
.innate immune response
  + 11 more...
.ubiquitin-protein transferase activity .extracellular exosome
.Cul7-RING ubiquitin ligase complex
.SCF ubiquitin ligase complex
  + 2 more...
4 EBI-741068,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
5 EBI-741068,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
6 EBI-741068,EBI-10173507 ADAMTSL4  
  .cellular protein metabolic process
.post-translational protein modification
.positive regulation of apoptotic process
  + 4 more...
.metalloendopeptidase activity
.protease binding
.endoplasmic reticulum lumen
.interstitial matrix
7 EBI-741068,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
8 EBI-741068,EBI-10185730 KRTAP9-4  
  .N/A .N/A .keratin filament
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites251
bladder33
blood130
bone83
bone marrow61
brain63
cervix412
connective tissue40
embryonic tissue61
esophagus99
eye114
heart22
intestine86
kidney104
liver9
lung119
lymph67
lymph node33
mammary gland39
muscle37
nerve193
ovary137
pancreas74
parathyroid48
pharynx24
placenta98
prostate84
salivary gland296
skin109
spleen18
stomach73
testis569
thymus25
tonsil58
uterus99
vascular19
Health State
TissuesTPM*
normal64
adrenal tumor158
bladder carcinoma56
breast (mammary gland) tumor32
cervical tumor260
chondrosarcoma181
colorectal tumor115
esophageal tumor115
gastrointestinal tumor151
germ cell tumor98
glioma111
head and neck tumor44
kidney tumor174
leukemia127
lung tumor223
lymphoma96
non-neoplasia41
ovarian tumor170
pancreatic tumor104
primitive neuroectodermal tumor of the CNS39
prostate cancer77
retinoblastoma43
skin tumor111
soft tissue/muscle tissue tumor95
uterine tumor122
Developmental Stage
TissuesTPM*
adult85
embryoid body114
blastocyst65
fetus41
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue36.8
adrenal gland24.7
appendix29
bone marrow29.4
cerebral cortex18.6
colon40.8
duodenum45.1
esophagus32.9
gallbladder22.1
heart muscle47.2
kidney29.7
liver24.5
lung26.7
lymph node31
ovary15.4
pancreas23.2
placenta21.9
prostate37.2
salivary gland43.3
skin31.4
small intestine41.7
spleen42.9
stomach41.1
testis122.5
thyroid gland19.7
urinary bladder26.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*609072, gene) F-box and wd40 domain protein 5; FBXW5OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center