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> Protein (NX_Q96AY2)
Protein (NX_Q96AY2)
Protein
Gene SymbolEME1 to neXtProt (NX_Q96AY2)
DescriptionCrossover junction endonuclease EME1
Chromosome17
Location17q21.33 (48450581 ~ 48458844) to Ensembl
Sequene Features : Isoforms 2, Variants 77, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.response to intra-S DNA damage checkpoint signaling
.DNA recombination
.DNA repair
.metal ion binding
.endonuclease activity
.DNA binding
.cytoplasm
.nucleolus
.nuclear heterochromatin
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 77 8
2014-09-19protein level
2 62 8
2014-05-27protein level
2 62 8
2014-02-25protein level
2 63 8
2013-12-09protein level
2 47 8
2013-11-01protein level
2 47 8
2013-09-12protein level
2 47 8
2013-08-17protein level
2 47 8
2013-07-15protein level
2 35 8
2013-06-11protein level
2 35 8
2013-02-12protein level
2 26 16
2012-12-20protein level
2 26 16
2012-10-30protein level
2 29 16
2012-10-07protein level
2 29 8
2012-08-24protein level
2 29 8
2012-07-28protein level
2 28 8
2012-06-08protein level
2 30 8
2012-05-07protein level
2 25 8
2012-04-10protein level
2 25 8
2012-01-13protein level
2 19 8
2011-12-20protein level
2 19 8
2011-11-11protein level
2 19 8
2011-08-23protein level
2 19 8
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96AY2-1
1 25 0 63212.0568
NX_Q96AY2-2
1 25 0 64737.8056
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2370825,EBI-2370740 SLX4  
  .response to intra-S DNA damage checkpoint signaling
.positive regulation of catalytic activity
.DNA double-strand break processing involved in repair via single-strand annealing
  + 4 more...
.5'-flap endonuclease activity
.enzyme activator activity
.Slx1-Slx4 complex
.cell junction
.cytoplasm
.nucleoplasm
2 EBI-2370825,EBI-2370806 MUS81  
  .response to intra-S DNA damage checkpoint signaling
.DNA recombination
.DNA repair
.DNA catabolic process, endonucleolytic
.3'-flap endonuclease activity
.metal ion binding
.DNA binding
.nucleolus
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
blood16
bone41
brain9
cervix41
connective tissue6
embryonic tissue18
esophagus49
eye14
intestine4
kidney18
larynx85
lymph node22
mammary gland6
muscle28
placenta14
prostate10
salivary gland49
skin4
stomach10
testis27
thymus25
uterus21
Health State
TissuesTPM*
normal9
breast (mammary gland) tumor10
cervical tumor57
chondrosarcoma36
esophageal tumor57
gastrointestinal tumor25
germ cell tumor30
glioma18
head and neck tumor22
kidney tumor14
leukemia42
primitive neuroectodermal tumor of the CNS110
prostate cancer19
retinoblastoma21
skin tumor7
soft tissue/muscle tissue tumor15
uterine tumor33
Developmental Stage
TissuesTPM*
adult11
blastocyst16
fetus21
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1.2
appendix2.5
bone marrow5.6
colon2.2
duodenum3.8
esophagus1.5
lymph node4.2
ovary1.3
placenta2.6
salivary gland1.5
skin2.8
small intestine1.7
spleen1.8
stomach1.4
testis10.8
urinary bladder1
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2High
epididymisMedium
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverMedium
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryMedium
pancreasHigh
parathyroid glandMedium
placentaHigh
prostateMedium
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleHigh
skin 1Medium
skin 2High
small intestineHigh
smooth muscleMedium
soft tissue 1High
soft tissue 2High
spleenHigh
stomach 1High
stomach 2High
testisMedium
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*610885, gene) Essential meiotic endonuclease 1, s. pombe, homolog of, 1; EME1OMIM


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