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> Protein (NX_Q96B02)
Protein (NX_Q96B02)
Protein
Gene SymbolUBE2W to neXtProt (NX_Q96B02)
DescriptionUbiquitin-conjugating enzyme E2 W
Chromosome8
Location8q21.11 (74692332 ~ 74791145) to Ensembl
Sequene Features : Isoforms 3, Variants 14, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to misfolded protein
.protein K11-linked ubiquitination
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 3 more...
.ubiquitin protein ligase activity
.ubiquitin protein ligase binding
.ubiquitin-like protein transferase activity
  + 3 more...
.cytoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 14 1
2014-09-19protein level
3 11 1
2014-05-27protein level
3 11 1
2014-02-25protein level
3 11 1
2013-12-09protein level
3 8 1
2013-11-01protein level
3 8 0
2013-09-12protein level
3 8 0
2013-08-17protein level
3 8 0
2013-07-15protein level
3 4 0
2013-06-11protein level
3 4 0
2013-02-12protein level
3 0 0
2012-12-20protein level
3 0 0
2012-10-30protein level
3 2 0
2012-10-07protein level
3 2 0
2012-08-24protein level
3 2 0
2012-07-28protein level
3 2 0
2012-06-08protein level
3 5 0
2012-05-07protein level
3 5 0
2012-04-10protein level
3 5 0
2012-01-13protein level
2 9 0
2011-12-20protein level
2 9 0
2011-11-11protein level
2 8 0
2011-08-23protein level
2 8 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96B02-1
0 5 0 17319.4558
NX_Q96B02-2
1 5 0 18648.1509
NX_Q96B02-3
1 5 0 20675.3131
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-716589,EBI-1050964 PSTPIP1  
  .innate immune response
.nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
.signal transduction
  + 3 more...
.N/A .perinuclear region of cytoplasm
.cleavage furrow
.lamellipodium
  + 5 more...
2 EBI-716589,EBI-739895 USHBP1  
  .N/A .PDZ domain binding .N/A
3 EBI-716589,EBI-348482 RNF5  
  .regulation of autophagic vacuole assembly
.ER-associated misfolded protein catabolic process
.protein K48-linked ubiquitination
  + 5 more...
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.mitochondrial membrane
.integral component of membrane
.endoplasmic reticulum membrane
4 EBI-716589,EBI-1378139 ROPN1  
  .small GTPase mediated signal transduction .N/A .cytoplasm
.nucleus
5 EBI-716589,EBI-2341610 MARCH5  
  .negative regulation of cell aging
.positive regulation of mitochondrial fission
.regulation of mitochondrial fission
  + 3 more...
.GTPase binding
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.integral component of membrane
.membrane
.endoplasmic reticulum membrane
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland91
bladder100
blood24
bone69
bone marrow41
brain53
connective tissue6
embryonic tissue37
esophagus99
eye43
heart78
intestine25
kidney56
liver29
lung32
lymph22
lymph node44
mammary gland66
mouth75
muscle75
nerve193
ovary9
pancreas28
pharynx73
placenta60
prostate10
salivary gland49
skin42
spleen18
stomach83
testis57
thymus25
thyroid21
trachea96
uterus34
vascular38
Health State
TissuesTPM*
normal51
adrenal tumor158
bladder carcinoma170
breast (mammary gland) tumor32
chondrosarcoma24
colorectal tumor17
esophageal tumor115
gastrointestinal tumor50
germ cell tumor41
glioma9
head and neck tumor22
kidney tumor29
leukemia21
liver tumor20
lung tumor9
lymphoma13
pancreatic tumor19
primitive neuroectodermal tumor of the CNS23
prostate cancer19
retinoblastoma64
skin tumor55
soft tissue/muscle tissue tumor23
uterine tumor22
Developmental Stage
TissuesTPM*
adult39
embryoid body42
blastocyst16
fetus53
infant42
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue10.1
adrenal gland12.2
appendix12.5
bone marrow7.8
cerebral cortex17.7
colon9.8
duodenum6.9
esophagus14.6
gallbladder14
heart muscle11.1
kidney15.6
liver9.5
lung9.4
lymph node10.6
ovary10
pancreas5.5
placenta11.1
prostate10.1
salivary gland6.9
skin5.8
small intestine7.2
spleen8.3
stomach9
testis14.9
thyroid gland16.3
urinary bladder17.6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*614277, gene) Ubiquitin-conjugating enzyme 2w; UBE2WOMIM


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