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> Protein (NX_Q96B26)
Protein (NX_Q96B26)
Protein
Gene SymbolEXOSC8 to neXtProt (NX_Q96B26)
DescriptionExosome complex component RRP43
Chromosome13
Location13q13.3 (37572953 ~ 37583750) to Ensembl
Sequene Features : Isoforms 1, Variants 29, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.gene expression
.rRNA processing
.nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.AU-rich element binding .cytosol
.cytoplasm
.nucleolus
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 29 1
2014-09-19protein level
1 20 1
2014-05-27protein level
1 20 1
2014-02-25protein level
1 20 1
2013-12-09protein level
1 16 1
2013-11-01protein level
1 16 1
2013-09-12protein level
1 16 0
2013-08-17protein level
1 16 0
2013-07-15protein level
1 11 0
2013-06-11protein level
1 11 0
2013-02-12protein level
1 7 0
2012-12-20protein level
1 6 0
2012-10-30protein level
1 5 0
2012-10-07protein level
1 5 0
2012-08-24protein level
1 4 0
2012-07-28protein level
1 4 0
2012-06-08protein level
1 5 0
2012-05-07protein level
1 4 0
2012-04-10protein level
1 4 0
2012-01-13protein level
1 6 0
2011-12-20protein level
1 6 0
2011-11-11protein level
1 6 0
2011-08-23protein level
1 6 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96B26-1
12 0 0 30020.2277
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-371922,EBI-707554 TXNDC9  
  .cell redox homeostasis .N/A .midbody
.centrosome
.cytoplasm
.nucleus
2 EBI-371922,EBI-1170906 ATF2  
  .positive regulation of mitochondrial membrane permeability involved in apoptotic process
.adipose tissue development
.stress-activated MAPK cascade
  + 27 more...
.metal ion binding
.cAMP response element binding
.protein kinase binding
  + 13 more...
.site of double-strand break
.mitochondrial outer membrane
.cytoplasm
  + 2 more...
3 EBI-371922,EBI-715032 COX5A  
  .hydrogen ion transmembrane transport
.small molecule metabolic process
.cellular metabolic process
  + 3 more...
.metal ion binding
.electron carrier activity
.cytochrome-c oxidase activity
.extracellular exosome
.mitochondrial inner membrane
4 EBI-371922,EBI-2514218 TFAP4  
  .positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.cellular response to dexamethasone stimulus
.negative regulation of cell cycle arrest
  + 12 more...
.E-box binding
.transcription regulatory region DNA binding
.sequence-specific DNA binding
  + 6 more...
.transcriptional repressor complex
.nucleus
5 EBI-371922,EBI-1054396 OTUD4  
  .protein K48-linked deubiquitination .poly(A) RNA binding
.ubiquitin-specific protease activity
.N/A
6 EBI-371922,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
7 EBI-371922,EBI-2515248 FRG1  
  .muscle organ development
.rRNA processing
.mRNA splicing, via spliceosome
.poly(A) RNA binding .catalytic step 2 spliceosome
.Z disc
.Cajal body
.nucleolus
8 EBI-371922,EBI-710310 TCEA2  
  .positive regulation of transcription from RNA polymerase II promoter
.regulation of DNA-templated transcription, elongation
.DNA-templated transcription, elongation
.zinc ion binding
.DNA binding
.transcription elongation factor complex
.centrosome
.nucleoplasm
9 EBI-371922,EBI-373279 COL23A1  
  .collagen catabolic process
.extracellular matrix organization
.extracellular matrix disassembly
.N/A .integral component of membrane
.plasma membrane
.endoplasmic reticulum lumen
.collagen trimer
10 EBI-371922,EBI-6658203 FAM90A1  
  .N/A .zinc ion binding
.nucleic acid binding
.N/A
11 EBI-371922,EBI-8637627 AEN  
  .nucleic acid phosphodiester bond hydrolysis
.intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
.response to ionizing radiation
.exonuclease activity
.nucleic acid binding
.nuclear membrane
.nucleolus
.nucleoplasm
.nucleus
12 EBI-371922,EBI-1055906 TXNDC17  
  .oxidation-reduction process
.tumor necrosis factor-mediated signaling pathway
.protein-disulfide reductase activity
.electron carrier activity
.peroxidase activity
.extracellular exosome
.cytosol
13 EBI-371922,EBI-724940 DUSP23  
  .N/A .protein tyrosine/serine/threonine phosphatase activity
.protein tyrosine phosphatase activity
.extracellular exosome
.cytosol
.nucleus
14 EBI-371922,EBI-371876 EXOSC5  
  .RNA phosphodiester bond hydrolysis, exonucleolytic
.polyadenylation-dependent snoRNA 3'-end processing
.nuclear mRNA surveillance
  + 10 more...
.RNA binding
.3'-5'-exoribonuclease activity
.transcriptionally active chromatin
.cytosol
.cytoplasm
  + 5 more...
15 EBI-371922,EBI-371866 EXOSC3  
  .polyadenylation-dependent snoRNA 3'-end processing
.nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription
.nuclear polyadenylation-dependent tRNA catabolic process
  + 12 more...
.RNA binding
.3'-5'-exoribonuclease activity
.transcriptionally active chromatin
.cytosol
.cytoplasm
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
ascites25
bladder301
blood163
bone97
bone marrow164
brain30
connective tissue33
ear62
embryonic tissue75
eye33
heart67
intestine51
kidney90
liver63
lung89
lymph45
lymph node89
mammary gland59
muscle37
pancreas51
parathyroid242
pharynx147
pituitary gland60
placenta31
prostate73
salivary gland444
skin37
spleen112
stomach20
testis50
thymus188
thyroid21
uterus56
vascular77
Health State
TissuesTPM*
normal60
bladder carcinoma511
breast (mammary gland) tumor10
chondrosarcoma36
colorectal tumor35
gastrointestinal tumor67
germ cell tumor94
glioma93
kidney tumor58
leukemia105
liver tumor20
lung tumor48
lymphoma27
non-neoplasia20
primitive neuroectodermal tumor of the CNS31
prostate cancer105
retinoblastoma21
skin tumor23
soft tissue/muscle tissue tumor55
uterine tumor66
Developmental Stage
TissuesTPM*
adult39
embryoid body71
blastocyst32
fetus73
infant42
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue17.9
adrenal gland19.1
appendix32.6
bone marrow32
cerebral cortex16.2
colon22.6
duodenum21
esophagus18.5
gallbladder16.8
heart muscle20.6
kidney16.3
liver13
lung21.3
lymph node40.9
ovary33.4
pancreas9
placenta25.5
prostate21.4
salivary gland17.5
skin28
small intestine22.5
spleen27.7
stomach21.4
testis40.8
thyroid gland20.6
urinary bladder21.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606019, gene) Exosome component 8; EXOSC8OMIM


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