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> Protein (NX_Q96B67)
Protein (NX_Q96B67)
Protein
Gene SymbolARRDC3 to neXtProt (NX_Q96B67)
DescriptionArrestin domain-containing protein 3
Chromosome5
Location5q14.3 (90664541 ~ 90679176) to Ensembl
Sequene Features : Isoforms 1, Variants 55, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of locomotion involved in locomotory behavior
.positive regulation of adrenergic receptor signaling pathway
.fat pad development
  + 5 more...
.beta-3 adrenergic receptor binding .plasma membrane
.endosome
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 55 0
2014-09-19protein level
1 43 0
2014-05-27protein level
1 43 0
2014-02-25protein level
1 42 0
2013-12-09protein level
1 36 0
2013-11-01protein level
1 35 0
2013-09-12protein level
1 35 0
2013-08-17protein level
1 35 0
2013-07-15protein level
1 20 0
2013-06-11protein level
1 20 0
2013-02-12protein level
1 8 0
2012-12-20protein level
1 8 0
2012-10-30protein level
1 9 0
2012-10-07protein level
1 9 0
2012-08-24protein level
1 5 0
2012-07-28protein level
1 5 0
2012-06-08protein level
1 6 0
2012-05-07protein level
1 6 0
2012-04-10protein level
1 6 0
2012-01-13protein level
1 1 0
2011-12-20protein level
1 1 0
2011-11-11protein level
1 1 0
2011-08-23protein level
1 1 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96B67-1
18 0 0 46365.193
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2875665,EBI-10187349 HPGDS  
  .glutathione derivative biosynthetic process
.small molecule metabolic process
.cyclooxygenase pathway
  + 5 more...
.protein homodimerization activity
.calcium ion binding
.prostaglandin-D synthase activity
  + 2 more...
.cytosol
.cytoplasm
2 EBI-2875665,EBI-373258 STAM2  
  .membrane organization
.negative regulation of epidermal growth factor receptor signaling pathway
.endosomal transport
  + 2 more...
.N/A .intracellular membrane-bounded organelle
.early endosome membrane
.cytosol
  + 2 more...
3 EBI-2875665,EBI-747185 BAG3  
  .regulation of cellular response to heat
.extrinsic apoptotic signaling pathway in absence of ligand
.cellular response to mechanical stimulus
  + 8 more...
.N/A .neuron projection
.Z disc
.plasma membrane
  + 2 more...
4 EBI-2875665,EBI-948678 ITGB4  
  .amelogenesis
.renal system development
.cell motility
  + 13 more...
.receptor activity
.G-protein coupled receptor binding
.extracellular exosome
.receptor complex
.cell leading edge
  + 6 more...
5 EBI-2875665,EBI-527670 TNFAIP3  
  .negative regulation of endothelial cell apoptotic process
.negative regulation of CD40 signaling pathway
.positive regulation of hepatocyte proliferation
  + 46 more...
.protein self-association
.ubiquitin binding
.ligase activity
  + 5 more...
.extracellular exosome
.cytosol
.centrosome
  + 3 more...
6 EBI-2875665,EBI-746259 OTUB2  
  .protein K48-linked deubiquitination
.protein K63-linked deubiquitination
.protein K11-linked deubiquitination
.protein deubiquitination
.ubiquitin-specific protease activity .nucleus
7 EBI-2875665,EBI-740086 DCUN1D1  
  .N/A .N/A .nucleus
.ubiquitin ligase complex
8 EBI-2875665,EBI-2129763 UBE2E2  
  .positive regulation of G1/S transition of mitotic cell cycle
.protein K11-linked ubiquitination
.protein K48-linked ubiquitination
  + 3 more...
.ubiquitin conjugating enzyme activity
.ISG15 transferase activity
.ligase activity
  + 2 more...
.N/A
9 EBI-2875665,EBI-399246 MORF4L1  
  .histone H2A acetylation
.histone H4 acetylation
.regulation of growth
  + 6 more...
.protein N-terminus binding
.chromatin binding
.NuA4 histone acetyltransferase complex
.Sin3 complex
.nucleoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland182
bladder200
blood24
bone41
brain36
cervix41
connective tissue33
embryonic tissue70
esophagus99
eye47
heart33
intestine34
kidney94
liver24
lung38
lymph node66
mammary gland99
mouth30
muscle56
nerve64
ovary59
pancreas60
parathyroid242
pharynx24
pituitary gland121
placenta130
prostate26
skin18
stomach10
testis13
thymus12
thyroid21
trachea270
uterus81
vascular96
Health State
TissuesTPM*
normal54
adrenal tumor237
bladder carcinoma227
breast (mammary gland) tumor75
cervical tumor28
chondrosarcoma60
colorectal tumor44
esophageal tumor115
gastrointestinal tumor25
germ cell tumor15
glioma18
head and neck tumor22
kidney tumor174
leukemia21
lung tumor9
non-neoplasia31
ovarian tumor78
pancreatic tumor9
primitive neuroectodermal tumor of the CNS23
prostate cancer19
skin tumor7
soft tissue/muscle tissue tumor71
uterine tumor66
Developmental Stage
TissuesTPM*
adult64
embryoid body114
blastocyst97
fetus39
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue30.1
adrenal gland84.6
appendix32.7
bone marrow123.6
cerebral cortex17.1
colon20.4
duodenum10.8
esophagus40.2
gallbladder46.4
heart muscle12.6
kidney52.3
liver43.8
lung51.2
lymph node31.5
ovary98.8
pancreas9.3
placenta78.9
prostate31.3
salivary gland34.5
skin27.9
small intestine17.3
spleen43.4
stomach28.3
testis22.8
thyroid gland90.9
urinary bladder45.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*612464, gene) Arrestin domain-containing 3; ARRDC3OMIM


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