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> Protein (NX_Q96B97)
Protein (NX_Q96B97)
Protein
Gene SymbolSH3KBP1 to neXtProt (NX_Q96B97)
DescriptionSH3 domain-containing kinase-binding protein 1
ChromosomeX
LocationXp22.12 (19552093 ~ 19905719) to Ensembl
Sequene Features : Isoforms 3, Variants 89, PTMs 13 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of epidermal growth factor receptor signaling pathway
.cell migration
.regulation of cell shape
  + 5 more...
.N/A .synapse
.neuron projection
.cytoplasmic vesicle membrane
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 89 13
2014-09-19protein level
3 60 13
2014-05-27protein level
3 60 13
2014-02-25protein level
3 59 13
2013-12-09protein level
3 44 13
2013-11-01protein level
3 43 13
2013-09-12protein level
3 43 15
2013-08-17protein level
3 43 15
2013-07-15protein level
3 31 15
2013-06-11protein level
3 31 15
2013-02-12protein level
3 19 22
2012-12-20protein level
3 19 22
2012-10-30protein level
2 23 16
2012-10-07protein level
2 23 8
2012-08-24protein level
2 12 8
2012-07-28protein level
2 12 8
2012-06-08protein level
2 13 8
2012-05-07protein level
2 13 8
2012-04-10protein level
2 13 8
2012-01-13protein level
2 8 8
2011-12-20protein level
2 8 8
2011-11-11protein level
2 8 8
2011-08-23protein level
2 8 8
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96B97-1
3 32 0 73081.4907
NX_Q96B97-2
1 32 0 68508.2719
NX_Q96B97-3
1 23 0 46581.0576
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-346595,EBI-310513 SYNJ2  
  .phosphatidylinositol dephosphorylation
.small molecule metabolic process
.phosphatidylinositol biosynthetic process
.phospholipid metabolic process
.phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
.RNA binding
.nucleotide binding
.membrane
.cytosol
2 EBI-346595,EBI-742487 SPRY2  
  .positive regulation of protein serine/threonine kinase activity
.positive regulation of ERK1 and ERK2 cascade
.negative regulation of ERK1 and ERK2 cascade
  + 19 more...
.protein serine/threonine kinase activator activity
.protein serine/threonine kinase inhibitor activity
.protein kinase binding
.ruffle membrane
.microtubule cytoskeleton
.plasma membrane
  + 2 more...
3 EBI-346595,EBI-5240523 DDN  
  .positive regulation of transcription from RNA polymerase II promoter .RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.perikaryon
.cell projection
.dendritic spine membrane
  + 3 more...
4 EBI-346595,EBI-3912464 CD2  
  .positive regulation of interleukin-8 secretion
.positive regulation of interferon-gamma secretion
.leukocyte migration
  + 11 more...
.receptor binding
.receptor activity
.anchored component of plasma membrane
.cell surface
.cytoplasmic side of plasma membrane
  + 5 more...
5 EBI-346595,EBI-3390054 UBC  
  .programmed necrotic cell death
.apoptotic signaling pathway
.energy homeostasis
  + 90 more...
.poly(A) RNA binding
.protease binding
.extracellular exosome
.endocytic vesicle membrane
.endosome membrane
  + 3 more...
6 EBI-346595,EBI-518228 CBL  
  .positive regulation of receptor-mediated endocytosis
.negative regulation of apoptotic process
.negative regulation of epidermal growth factor receptor signaling pathway
  + 7 more...
.ubiquitin protein ligase activity
.ephrin receptor binding
.SH3 domain binding
  + 6 more...
.flotillin complex
.plasma membrane
.cytosol
  + 2 more...
7 EBI-346595,EBI-346547 DNM2  
  .negative regulation of membrane tubulation
.membrane organization
.regulation of nitric-oxide synthase activity
  + 16 more...
.enzyme binding
.SH3 domain binding
.microtubule binding
  + 2 more...
.extracellular exosome
.postsynaptic membrane
.endocytic vesicle membrane
  + 10 more...
8 EBI-346595,EBI-355586 CAPZA1  
  .barbed-end actin filament capping
.innate immune response
.blood coagulation
  + 2 more...
.actin binding .WASH complex
.extracellular exosome
.actin cytoskeleton
  + 4 more...
9 EBI-346595,EBI-727062 SH3BP2  
  .positive regulation of signal transduction
.signal transduction
.SH3/SH2 adaptor activity .N/A
10 EBI-346595,EBI-744027 CBLB  
  .negative regulation of T cell receptor signaling pathway
.negative regulation of alpha-beta T cell proliferation
.positive regulation of protein catabolic process
  + 7 more...
.ligase activity
.zinc ion binding
.calcium ion binding
  + 2 more...
.plasma membrane
.cytosol
.cytoplasm
.nucleoplasm
11 EBI-346595,EBI-307104 SQSTM1  
  .activation of mitophagy in response to mitochondrial depolarization
.apoptotic signaling pathway
.protein heterooligomerization
  + 20 more...
.ubiquitin binding
.identical protein binding
.SH2 domain binding
  + 5 more...
.extracellular exosome
.cytoplasmic vesicle
.PML body
  + 11 more...
12 EBI-346595,EBI-4402732 ARAP3  
  .regulation of small GTPase mediated signal transduction
.negative regulation of Rho protein signal transduction
.negative regulation of Rac protein signal transduction
  + 5 more...
.phosphatidylinositol-3,4-bisphosphate binding
.zinc ion binding
.phosphatidylinositol-3,4,5-trisphosphate binding
.GTPase activator activity
.lamellipodium
.plasma membrane
.cytoskeleton
  + 3 more...
13 EBI-346595,EBI-1380477 INPP5D  
  .leukocyte migration
.T cell receptor signaling pathway
.negative regulation of immune response
  + 22 more...
.phosphatidylinositol trisphosphate phosphatase activity
.inositol-polyphosphate 5-phosphatase activity
.membrane
.cytosol
14 EBI-346595,EBI-77938 SH3GL2  
  .membrane organization
.synaptic vesicle endocytosis
.neurotrophin TRK receptor signaling pathway
  + 8 more...
.identical protein binding
.lipid binding
.extracellular exosome
.clathrin-coated endocytic vesicle membrane
.plasma membrane
  + 2 more...
15 EBI-346595,EBI-346622 ASAP1  
  .cilium morphogenesis
.organelle organization
.zinc ion binding
.phosphatidylinositol-3,4,5-trisphosphate binding
.phosphatidylinositol-4,5-bisphosphate binding
.GTPase activator activity
.membrane
.cytosol
16 EBI-346595,EBI-6083058 STAP1  
  .positive regulation of actin cytoskeleton reorganization
.positive regulation of non-membrane spanning protein tyrosine kinase activity
.positive regulation of microglial cell activation
  + 10 more...
.protein kinase binding
.phospholipid binding
.SH3/SH2 adaptor activity
  + 2 more...
.protein complex
.mitochondrion
.cytoplasm
.nucleus
17 EBI-346595,EBI-448104 MAP3K4  
  .positive regulation of p38MAPK cascade
.chorionic trophoblast cell differentiation
.positive regulation of JUN kinase activity
  + 8 more...
.metal ion binding
.ATP binding
.MAP kinase kinase kinase activity
.MAP kinase kinase activity
.perinuclear region of cytoplasm
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
blood98
bone69
bone marrow20
brain58
connective tissue73
ear62
embryonic tissue75
eye47
heart67
intestine68
kidney28
larynx213
liver87
lung101
lymph586
lymph node167
mammary gland105
mouth15
muscle75
nerve64
ovary9
pancreas46
placenta70
prostate26
skin99
spleen56
stomach31
testis4
thymus100
thyroid85
tonsil58
trachea19
umbilical cord290
uterus77
vascular174
Health State
TissuesTPM*
normal59
adrenal tumor79
breast (mammary gland) tumor150
chondrosarcoma72
colorectal tumor71
gastrointestinal tumor25
germ cell tumor45
glioma65
head and neck tumor67
kidney tumor43
leukemia74
liver tumor135
lung tumor165
lymphoma373
non-neoplasia82
ovarian tumor52
pancreatic tumor47
primitive neuroectodermal tumor of the CNS15
prostate cancer28
retinoblastoma21
skin tumor119
soft tissue/muscle tissue tumor127
uterine tumor44
Developmental Stage
TissuesTPM*
adult57
embryoid body142
blastocyst16
neonate257
fetus34
juvenile107
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue43.7
adrenal gland12
appendix49.9
bone marrow51.8
cerebral cortex21.3
colon40.8
duodenum13.8
esophagus14.1
gallbladder32.6
heart muscle14.7
kidney14.4
liver12.1
lung31.9
lymph node79.6
ovary12.6
pancreas4.6
placenta41
prostate7.4
salivary gland9.2
skin15.1
small intestine19.4
spleen39.2
stomach23
testis10.3
thyroid gland32
urinary bladder32.9
Tissues
TissuesExpression level
appendixHigh
bone marrowMedium
breastLow
cerebellumLow
cerebral cortexLow
hippocampusLow
lateral ventricleLow
lymph nodeHigh
placentaMedium
skin 1Low
soft tissue 1Low
soft tissue 2Low
spleenHigh
tonsilHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*300374, gene) Sh3-domain kinase-binding protein 1; SH3KBP1OMIM


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